Kat7 gene inactivation rejuvenates prematurely aging human cells and mice and promotes longevity.

CRISPR-induced KAT7 gene inactivation rejuvenates prematurely aging human cells and mice and promotes longevity.

Changes in the body that come from space travel resemble growing older, providing opportunities to perform aging studies on astronauts.

Spending time in outer space can mimic the effects of aging, and scientists have begun using the unique environment of space as a place to study aging.

How Aging is Affected by Space Travel

Others

Limited rapamycin exposure late in life was as effective as continuous exposure in increasing survival in males but not females

Late-life rapamycin administration regimens enhance mouse lifespan in a sex-dependent manner with limited exposure more effective in males than females.

Longevity

A study from UPenn scientists shows rapamycin prevents age-related alterations of metabolic state in muscle cells, which may extend lifespan.

Rapamycin increases the NAD+/NADH ratio and subsequent metabolic balance by reducing NADH levels in mouse muscle.

Genetically modified mouse cells with artificial activation of a nicotinamide adenine dinucleotide (NAD+) regulating enzyme are protected from cessation of cell proliferation induced by stress, maintaining healthy aging.

Artificially-activated Nampt enzyme promotes cellular protection from stress-induced cessation of cell proliferation.

Enzyme Regulating NAD+ Facilitates Cell Replication 

Scientists repurposed a blood cancer treatment using genetically modified immune cells called CAR T cells to reverse age-associated tissue damage.

A cellular therapy typically used against blood cancer called CAR T therapy improved tissue health by destroying senescent cells in mice.

Boosting nicotinamide adenine dinucleotide (NAD+) levels restores improves circadian rhythms in old mice through youthful gene activation and metabolic patterns, revealing that NAD+ governs both behavior and metabolic health.

Scientists Develop New Anti-Aging CRISPR-Based Gene Therapy

How Does Space Travel Affect Natural Aging?

Late-Life Rapamycin Regimens Extend Mouse Lifespan in a Sex-Specific Manner

Rapamycin’s Improvement of Muscle Cell Metabolic Balance May Enhance Longevity

Enzyme Regulating NAD+ Keeps Mouse Cells Replicating Under Stress

Blood Cancer Therapy May Offer a Strategy to Treat Age-Related Diseases

NAD+ Keeps the Mouse Body Clock Young to Counter Aging