Model: C57BL/6J mice 
Dosage: 300 mg/kg of alpelisib in food beginning at 12 months of age until death

The Nature Aging study supports the need for clinical tests of how adding alpesilib to diets affects longevity and aging.

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JGinsulinmain

Lead author, Dr. Chris Hedges | University of Auckland 

Northwestern University Study Shows Pro-Longevity Molecules Reverse Age-Associated Transcription Deficiency

In multiple species, longer strands of mRNA have lower abundance with age, but pro-longevity molecules counter this effect.

amaral

Amaral

(The study’s Principal Investigator Luis A.N. Amaral, PhD | Flickr.com)

Gene activity declines for longer genes and increases for shorter genes, which reduces the abundance of pro-longevity proteins and increases anti-longevity proteins with age.

Model: Male C57BL/6 mice
Dosage: 10 µg/day MR409 injected subcutaneously for 4 months beginning in old age

By restoring growth hormone secretion with a peptide (tiny protein) called MR409, researchers improve old mice's physical activity, hair growth, and heart function while increasing survival. 


andrewschally

Andrew Schally in the lab

Author and Nobel Laureate, Dr. Andrew V. Schally | Miami VA Healthcare System 

Model: C57BL/6J Mice
Dosage: 20 ug of sEVs’ protein on days 1 and 14 of experiment

Particles Secreted from Stem Cells Significantly Reduce Aging

University of Valencia researchers use small vesicles (sEVs) derived from young stem cells (ADSC) to reduce frailty, regulate inflammation, and lower senescence - a critical dormant state of cell-cycle arrest that drives aging. 


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sEVs Senior Author

Senior author, Dr. Consuelo Borras | INCLIVA

Longevity

Model: female ICR-CD1 mice
Dosage (oral): 2 x 10^8 cfu/100µL AKK daily for one month

Spanish scientists find that a probiotic prolongs lifespan, rejuvenates strength and coordination, and improves the immune system of old mice. 

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probiotic

Electron microscope image of probiotic (AKK) | Derrien et al., 2017

C57BL/6J mice (16 male; 16 female)
Diet supplemented with glycine and N-acetylcysteine (protein 23.5%, 3.0 kcal/g feed, Nacetylcysteine (NAC) 1.6 mg/g feed and glycine 1.6 mg/g feed

Antioxidant Cocktail Increases Lifespan and Attenuates Aging Hallmarks

Researchers from Baylor College show that glycine and N-acetylcysteine (GlyNAC) significantly increases mouse lifespan and improves multiple aging hallmarks. 


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Houston,,Texas,,Usa,-,March,9,,2022:,Closeup,Of,Baylor

Model: Prematurely aged (progeria) mice
Dosage: Tail vein injection of mTERT (mouse telomerase) lentiviral constructs

Using a therapy that extends telomeres — the DNA at the ends of our chromosomes, scientists reduce senescence in human cells and significantly prolong the lifespan of mice. 


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main

Senior author, Dr. John Cooke with research team | Credit: Daniel Kramer, Houstonia 

Model: Genetically diverse UMHET3 mice bred from CByB6F1/J female mice and C3D2F1/J male mice (monitored first 45 days of life). 
Dosage: Chow containing encapsulated rapamycin (42 ppm of active compound) for 45 days.

Harvard Study Shows Rapamycin Increases Lifespan but Inhibits Growth

Scientists find that treating mice with rapamycin early in life moderately increases lifespan and improves physical fitness at the expense of inhibiting growth in mice. 


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EL rap picture

Author, Dr. Leonid Peshkin | Longevity.Technology 

Model: Sprague Dawley rats
Dosage (oral): 0.1 mg/kg chloroquine

Chloroquine Extends Lifespan and Rejuvenates Multiple Organs

Chinese researchers show that the anti-malaria drug chloroquine moderately extends the lifespan and rejuvenates the organs of elderly rats.

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Structural,Chemical,Formula,Of,Chloroquine,Molecule,With,Pills,And,Tablets.

Embryo with Beating Heart Grown in Lab

Israeli scientists successfully grow embryos with functioning hearts in a test tube using mouse embryonic stem cells. 


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Picture0

Senior author, Dr. Jacob H. Hanna holding synthetic embryos | eNCA, AFP/Ahmad Gharabli 

FDA-Approved Insulin Inhibitor Extends Mouse Lifespan 10%

Northwestern University Study Shows Longevity-Promoting Molecules Reverse Aging-Associated Transcription Deficiency

Scientists Reduce Multiple Effects of Aging with Growth Hormone Stimulator

New Study Shows Particles Secreted from Stem Cells Significantly Reduce Aging

Scientists Find Probiotic Improves Longevity of Mice

Baylor College Scientists Increase Lifespan and Attenuate Aging Hallmarks with Antioxidant Cocktail

Scientists Prolong Mouse Lifespan by Extending Telomeres

Harvard Study Shows Rapamycin Increases Lifespan but Inhibits Growth

Study Shows Chloroquine Extends Lifespan and Rejuvenates Multiple Organs

Israeli Researchers Grow Embryo with Beating Heart in Breakthrough Study