A Vanderbilt University neuroscientist detects possible fraudulent claims regarding a landmark 2006 study, possibly uprooting a prevalent theory regarding Alzheimer’s disease progression.


3dillustrationofprivateinvestigatorfileswiththewordsinvestigation

3d,Illustration,Of,Private,Investigator,Files,With,The,Words,Investigation

Model: male Sprague-Dawley rats
Dosage: 5 mg/kg of honokiol (injection) or 15 mg/kg icariin (oral)

NMN and Herbal Medicines Prevent Neuron Death in Parkinson’s

Scientists report that the NAD+ precursor NMN and traditional East Asian herbal compounds icariin and honokiol prevent neuron death in a cell and animal model for Parkinson’s disease. 


1521649756129

Magnolia flowering plant, where honokiol can be derived (Shutterstock/Nikolay Kurzenko)

Flu Vaccine Associated with 40% Decreased Alzheimer’s Risk 

A study of nearly 2 million older individuals shows that the influenza vaccination leads to a 40% reduction in the risk of Alzheimer’s disease. 


dr-shulz-uthealth

Dr. Shulz UTHealth

Senior Author,Paul E. Schulz, MD | UTHealth Houston 

Model: female C57BL/6J mice
Dosage: 300 mg/kg plasmalogens enriched in eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and other omega-3 fatty acids dissolved in drinking water.

Fat Molecules Improve Age-Related Cognitive Deficits 

Chinese scientists show that aged mice treated with fats called plasmalogens have improvements in learning and memory due to enhanced neuron generation and connectivity.


picture0

Picture0

Microglia cells in aged mouse brain | Gu et al., 2022 

B6 congenic 5XFAD 4-month-old mice
Wildtype B6 mice
100 µL F. nucleatum
&nbsp;

Gum Disease May Increase Alzheimer’s Risk

Researchers show that the oral pathogen Fusobacterium nucleatum (F. nucleatum) decreases cognitive function and exacerbates Alzheimer's features in mice modeling Alzheimer's. 

asianfemalepatientondentistappointmentduringdentalprocedure-human

Asian,Female,Patient,On,Dentist,Appointment,During,Dental,Procedure.,Human

Neurodegeneration

Anti-Aging Protein Mimics Mental Stimulation

UCSF scientists find that the anti-aging protein klotho counters memory deficiencies in aged mice and activates metabolites associated with cognitive stimulation.


picture0-2

Senior Investigator Dena Dubal, M.D., Ph.D. | universityofcalifornia.edu 

Model: male APP/PS1 double transgenic mice
Dose: 10 mg/kg agomelatine by intraperitoneal injection 
&nbsp;

Agomealtine Prevents Cognitive Deficits in Alzheimer’s 

Chinese scientists find that the antidepressant drug agomelatine reverses cognitive deficits in a mouse model for Alzheimer’s disease.

main-5

main

Model: Older adults with varying levels of cognitive decline 
Dosage (oral): 1,700 mg DHA, 600 mg EPA, 0.5 mg B12, 1 mg B9, and 20 mg B6

Several recent studies suggest that the effectiveness of alleviating cognitive deficits with omega-3s in older adults depends on vitamin B levels. 


vitaminbtabletsonyellowbackground

Vitamin,B,Tablets,On,Yellow,Background

Stony Brook and Harvard scientists find that brain aging is accerlated by 26% in type 2 diabetes patients.  

picture1-2-2

Picture1-2

Brain Scan of Diabetes Patient | Antal et al., 2022

Medicinal Mushroom Restores Age-Related Physical Decline 

Italian researchers find that treating aged mice with Lion’s Mane (H. Erinaceus primordium) extract  boosts physical performance and improves neural oxidative stress.


Falsified Data Could Set Alzheimer’s Research Back 16 Years

Study Shows NMN and Herbal Medicines Prevent Neuron Death in Parkinson’s Models

UTHealth Researchers Show Flu Vaccine Associated with 40% Decreased Alzheimer’s Risk

Study Finds Fat Molecules that Improve Age-Related Cognitive Deficits

Gum Disease Pathogen Fusobacterium nucleatum May Increase Alzheimer’s Risk

Study Suggest Anti-Aging Protein Mimics Mental Stimulation in Mice

Study Shows Agomelatine Prevents Cognitive Deficits in Alzheimer’s

How B Vitamins and Omega-3s Could Prevent Cognitive Decline

New Study Shows Type 2 Diabetes Accelerates Brain Aging

Study Shows Lion’s Mane Restores Physical Performance in Aged Mice