What is NAD?

Learn how NAD+ can extend your healthspan.

Human Trial Finds Nitrate-Enhanced Juice Lowers Blood Pressure

Seragon’s Aging Intervention Drug SRN-901 Achieves One of the Largest Extensions of Lifespan and Healthspan to Date

NAD+ and Aging: What the Latest Research Says

How to Take Care of Your Aging Brain Cells: Stanford Study Insights

Nicotinamide + Ergothioneine Reboot Autophagy and Ease Hallmarks of Brain Aging

Low-Volume Beer Counters Age-Related Metabolic Decline, New Study Shows

Harvard Study: A Low Dose of Lithium May Preserve Cognitive Resilience with Age

NMN & NR

Nicotinamide mononucleotide (NMN) increases blood levels of nicotinamide adenine dinucleotide (NAD+) to alleviate age-related disorders like metabolic disease and cardiovascular dysfunction.

Clinical Trials

New Study Shows NMN Substantially Increases NAD+ and Enhances Physical Performance

NMN increases blood NAD+, enhances walking distance over a six-minute period, and improves a self-assessed evaluation of health, especially at higher doses in healthy adults.

Harvard Study: NMN Cuts Weight, Cholesterol, and Blood Pressure in Overweight Adults

NMN supplementation significantly reduces body weight, cholesterol, and blood pressure when blood fills the heart (diastolic blood pressure) in overweight or obese adults.

Latest UPenn Study Reveals NMN and NR Have Similar Efficacy in a Kidney Disease Model

Supplementing with nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR) confers comparable benefits against kidney disease in male mice.

This NAD+ precursor shields the heart from injury caused by a chemotherapeutic in rats, preventing the disruption of tissue organization and blood pumping abilities.

This NAD+ precursor shields the heart from injury caused by a chemotherapeutic in rats, preventing the disruption of tissue organization and blood pumping abilities.

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Aging & Longevity

David Sinclair’s 2024 Anti-Aging Supplement Protocol

Longevity expert Dr. David Sinclair's 2024 anti-aging protocol includes NMN, fish oil, lipoic acid, resveratrol, metformin, spermidine, and more.

A high but not low dose of nattokinase is associated with reducing artery plaque size by 36% in older adults.

A high but not low dose of nattokinase is associated with reducing artery plaque size by 36% in older adults.

Aging & Longevity

94-Year-Old Clint Eastwood’s Longevity Secrets

A series of realizations and personal experiences — like his father’s death from cardiovascular disease — have propelled Clint Eastwood to take care of his health for graceful aging.

Clinical trials show that urolithin A enhances muscle strength and reduces inflammation.

Clinical trials show that urolithin A enhances muscle strength and reduces inflammation.

The potential pitfalls of boosting NAD+ levels with NR, NMN, niacin, and nicotinamide are discussed.

The potential pitfalls of boosting NAD+ levels with NR, NMN, niacin, and nicotinamide are discussed.

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Latest News

Eric Verdin, M.D., and Peter Attia, M.D., discuss the controversy surrounding NAD+ (nicotinamide adenine dinucleotide), the best method for replenishing NAD+, and more.

Eric Verdin, M.D., and Peter Attia, M.D., discuss the controversy surrounding NAD+ (nicotinamide adenine dinucleotide), the best method for replenishing NAD+, and more.

Aging & Longevity

99-Year-Old Dick Van Dyke’s Secrets to Thriving Longevity

Despite his previous battles with alcoholism, Dick Van Dyke is approaching his 10th decade of life and serves as a beacon for preserving physical function into his golden years.

In a randomized clinical trial, active and healthy older adults who took a multi-supplement and omega-3 fatty acids saw a reduction in age-related chronic inflammation after 12 weeks.

In a randomized clinical trial, active and healthy older adults who took a multi-supplement and omega-3 fatty acids saw a reduction in age-related chronic inflammation after 12 weeks.

Making CAR-T Cells Young Again: Restoring NAD+ to Rejuvenate Immunotherapy in Aging

A combined treatment of NMN with 78c (a small molecule that inhibits an NAD+-degrading enzyme) enhances the effects of the anti-cancer CAR-T cell therapy in aged mice and human cells.

Aging & Longevity

The theory says our brain allocates resources to energy-consuming senescent cells at the body’s expense, accounting for gray hair, muscle shrinkage, and other signs of aging.

The theory says our brain allocates resources to energy-consuming senescent cells at the body’s expense, accounting for gray hair, muscle shrinkage, and other signs of aging.

Aging & Longevity

Anti-Aging Breakthrough? Harvard's David Sinclair Predicts Age-Reversing Pill by 2035

A leading thinker in the field of aging research, Dr. David Sinclair, shares insights on the rapid pace of advancements in aging research and predicts the availability of age-reversing pills within the next 10 years.

While improving immune health, the NAD+ (nicotinamide adenine dinucleotide) precursor NR (nicotinamide riboside) may induce anxiety-like behavior in stressed, aged mice.

While improving immune health, the NAD+ (nicotinamide adenine dinucleotide) precursor NR (nicotinamide riboside) may induce anxiety-like behavior in stressed, aged mice.

Aging & Longevity

Supplements like NAD+ boosters may benefit older individuals, while drugs like metformin and interventions such as physical exercise may not, according to German scientists.

Supplements like NAD+ boosters may benefit older individuals, while drugs like metformin and interventions such as physical exercise may not, according to German scientists.

A high but not low dose of nattokinase is associated with reducing artery plaque size by 36% in older adults.

A high but not low dose of nattokinase is associated with reducing artery plaque size by 36% in older adults.

Clinical Trials

A natural supplement, quercetin, targets age-promoting senescent cells, reduces inflammation, and counteracts blood vessel aging in men with heart disease.

A natural supplement, quercetin, targets age-promoting senescent cells, reduces inflammation, and counteracts blood vessel aging in men with heart disease.

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