What is NAD?

Learn how NAD+ can extend your healthspan.

Remembering Jane Goodall: The Simple Habits That Kept Her Mind Sharp for 91 Years

Seragon’s Aging Intervention Drug SRN-901 Achieves One of the Largest Extensions of Lifespan and Healthspan to Date

Longevity Drug Rapamycin Improves the Heart of Older Adults, New Study Shows

Ancient Plant Compound Shows Promise for Protecting the Aging Brain

New UC Berkeley Study: “Love Hormone” and Anti-Inflammatory Combo Extend Life

Three Compounds Show Promise for Male Longevity

α-Lipoic Acid: Efficacy, Safety, and Dosage

NMN & NR

Nicotinamide mononucleotide (NMN) increases blood levels of nicotinamide adenine dinucleotide (NAD+) to alleviate age-related disorders like metabolic disease and cardiovascular dysfunction.

Clinical Trials

New Study Shows NMN Substantially Increases NAD+ and Enhances Physical Performance

NMN increases blood NAD+, enhances walking distance over a six-minute period, and improves a self-assessed evaluation of health, especially at higher doses in healthy adults.

Harvard Study: NMN Cuts Weight, Cholesterol, and Blood Pressure in Overweight Adults

NMN supplementation significantly reduces body weight, cholesterol, and blood pressure when blood fills the heart (diastolic blood pressure) in overweight or obese adults.

Latest UPenn Study Reveals NMN and NR Have Similar Efficacy in a Kidney Disease Model

Supplementing with nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR) confers comparable benefits against kidney disease in male mice.

This NAD+ precursor shields the heart from injury caused by a chemotherapeutic in rats, preventing the disruption of tissue organization and blood pumping abilities.

This NAD+ precursor shields the heart from injury caused by a chemotherapeutic in rats, preventing the disruption of tissue organization and blood pumping abilities.

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Aging & Longevity

Chinese scientists have genetically engineered stem cells capable of rejuvenating the health, including the cognition, of aged macaques.

Chinese scientists have genetically engineered stem cells capable of rejuvenating the health, including the cognition, of aged macaques.

Aging & Longevity

David Sinclair’s 2024 Anti-Aging Supplement Protocol

Longevity expert Dr. David Sinclair's 2024 anti-aging protocol includes NMN, fish oil, lipoic acid, resveratrol, metformin, spermidine, and more.

Aging & Longevity

Want to Get Fit? Look at What Sylvester Stallone Does at 78

Sylvester Stallone’s daily diet includes egg whites as well as broiled chicken and fish for plenty of protein, and his most current workouts focus on the chest, back, abs, and legs for optimal longevity.

A high but not low dose of nattokinase is associated with reducing artery plaque size by 36% in older adults.

A high but not low dose of nattokinase is associated with reducing artery plaque size by 36% in older adults.

Clinical trials show that urolithin A enhances muscle strength and reduces inflammation.

Clinical trials show that urolithin A enhances muscle strength and reduces inflammation.

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Latest News

Brain & Neurons

Cutting-edge technology has allowed scientists to examine young and old brains with single-cell resolution, gaining insights into how we can rejuvenate our brain cells to stay sharp.

Cutting-edge technology has allowed scientists to examine young and old brains with single-cell resolution, gaining insights into how we can rejuvenate our brain cells to stay sharp.

Brain & Neurons

Study shows that brief nicotinamide + EGCG treatment restores neuronal energy in 16–24 hours, restores autophagy, reduces amyloid-beta buildup, and boosts neuron survival by ~22% in aging/Alzheimer’s lab models.

Study shows that brief nicotinamide + EGCG treatment restores neuronal energy in 16–24 hours, restores autophagy, reduces amyloid-beta buildup, and boosts neuron survival by ~22% in aging/Alzheimer’s lab models.

Three types of beer, including IPA and stout, are shown to improve indicators of metabolic health in a mouse model for aging.

Three types of beer, including IPA and stout, are shown to improve indicators of metabolic health in a mouse model for aging.

Brain & Neurons

Harvard Study: A Low Dose of Lithium May Preserve Cognitive Resilience with Age

Researchers uncover significantly lower brain lithium levels in Alzheimer’s disease patients, and supplementing with a low-dose lithium salt restores memory in an Alzheimer’s disease mouse model.

Older adults taking low-dose rapamycin exhibit a reduction in senescent cells — cells that contribute to age-related diseases and a shorter lifespan.

Older adults taking low-dose rapamycin exhibit a reduction in senescent cells — cells that contribute to age-related diseases and a shorter lifespan.

Aging & Longevity

The plant-based compound Harmine counteracts the cellular aging triggered by sleep deprivation in animal models and human cells.

The plant-based compound Harmine counteracts the cellular aging triggered by sleep deprivation in animal models and human cells.

Aging & Longevity

A Harvard-Trained Doctor’s Top 5 Anti-Aging Supplements

An aging research aficionado, Dr. Josh Helman, shares five supplements that can help fight the effects of aging: nitric oxide, NMN, honokiol, modified citrus pectin, and creatine.

Aging & Longevity

Seragon Biosciences has launched its new sleep and longevity optimizer, Enlivien, featuring technology based on a Harvard University collaboration.

Seragon Biosciences has launched its new sleep and longevity optimizer, Enlivien, featuring technology based on a Harvard University collaboration.

Eric Verdin, M.D., and Peter Attia, M.D., discuss the controversy surrounding NAD+ (nicotinamide adenine dinucleotide), the best method for replenishing NAD+, and more.

Eric Verdin, M.D., and Peter Attia, M.D., discuss the controversy surrounding NAD+ (nicotinamide adenine dinucleotide), the best method for replenishing NAD+, and more.

Aging & Longevity

99-Year-Old Dick Van Dyke’s Secrets to Thriving Longevity

Despite his previous battles with alcoholism, Dick Van Dyke is approaching his 10th decade of life and serves as a beacon for preserving physical function into his golden years.

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