Participants: Healthy, overweight older adults 
Dosage: 6 mg/day of spermidine supplemented orally for 13 weeks

Oxford scientists find that spermidine, a naturally occurring molecule that declines with age, rejuvenates aging immune cells and improves vaccine protection in older adults. 


Study conducted at the University of Oxford in England. 

Immunity

Japanese scientists have found that reducing NAD+ (nicotinamide adenine dinucleotide) transport into mitochondria within the fat tissue of mice induces metabolic dysregulation and obesity. 

Duke University scientists have successfully induced new neuronal connections in the brains of mice, leading to improvements in social interaction and stress resilience. 

Brain &amp; Neurons

Participants: Prefrail older adults
Dosage: 50 mg/day of losartan for at least 8 weeks

Losartan, a common blood pressure medication, increases the survival rate of mice and improves the metabolic outlook of pre-frail older adults. 

Principal Investigator of the study, Dr. Peter M. Abadir (image: jhu.edu).

Aging &amp; Longevity

Model: 8-month-old female Swiss mice
Dosage: 200 µL of aged-derived fecal suspension administered orally three days per week for two weeks

New Study: Transferring Gut Microbes from Old to Adult Mice Shortens Lifespan

Spanish scientists unveil data showing that transferring fecal microbes from old to adult mice increases biological age and shortens lifespan.

(A depiction of the intestines filled with gut microbes | Northwestern Medicine)

Spanish scientists show that transferring fecal microbes from old to adult mice increases biological age and shortens lifespan.

Participants: Older adults (ages 60 to 80) with mild cognitive impairment 
Dosage: 320 mg/day of anthocyanin capsules for 24 weeks

Anthocyanin, a compound found in berries, reduces inflammation and heart disease markers in older adults at risk for dementia.  

Lead author of the study, Dr. Miguel Germán Borda (image: noticias.cun.es).

Cardiovascular

David Attenborough Turns 100: 5 Longevity Habits of the Renowned British Broadcaster

David Attenborough’s longevity secrets encompass simple practices, such as walking, eating plant foods, spending time in nature, and maintaining social connections.

David Attenborough’s longevity secrets include not eating much meat, having a sense of purpose, eating small meals, spending time in nature, and maintaining social connections.

Cellular reprogramming, an innovative age-reversal technology, stimulates the regeneration of heart cells after a heart attack in mice. 

Peter Fedichev’s Physics-Based Approach to Aging: A New Longevity Framework

Peter Fedichev describes aging as a three-variable system of stress (from physical, psychological, or molecular stressors), noise (small random biological fluctuations), and damage (cumulative wear-and-tear).

Peter Fedichev has proposed a physics-based framework for aging, encompassing stress, noise (small random biological fluctuations), and damage (cumulative wear-and-tear).

Participants: Sedentary older adults 
Dosage: 6 mg/week of rapamycin

In older adults, the FDA-approved drug rapamycin, associated with prolonging lifespan, blunts improvements in physical performance.

Spermidine Boosts Immune Cells and Vaccine Protection, New Study Shows

NAD+ Transporter Prevents Obesity Caused by Aging: New Study Shows

Can We Reverse Memory Loss? Duke Scientists Find New Way to Rewire the Brain

New Johns Hopkins Study: FDA-Approved Losartan May Extend Lifespan

New Study: Transferring Gut Microbes from Old to Adult Mice Shortens Lifespan

Anthocyanin Supplement Shows Anti-Inflammatory and Heart Health Benefits in New Study

David Attenborough Turns 100: 5 Longevity Habits of the Renowned British Broadcaster

New Age-Reversing Tech Helps Heart Regenerate, Scientists Find

Peter Fedichev’s Physics-Based Approach to Aging: A New Longevity Framework

Rapamycin and Exercise: New Study Finds Potential Performance Decline