Manipulating Aging Through Cutting-Edge Gene Therapies

Gene therapy techniques like CRISPR and RNA replacement compensate for or replace defective longevity-associated genes like KLOTHO or FOXO genes.

(A scientist in a laboratory performing gene therapy research)

Researchers continue to develop ways to substitute, edit, and delete gene sequences to engineer and improve the expression of certain genes related to aging.

Reviews

Sirtuin Modulating Compounds: Influencing the Function of Key Proteins for Longevity

Individually targeting the seven types of sirtuins with molecules to activate or inhibit their function has a wide range of beneficial effects against age-associated conditions like cancer and diabetes.

(The structural folding patterns of all seven sirtuins | Molecules)

Individually targeting the seven sirtuins through their activation or inhibition can improve cancer, neurodegenerative disease, and metabolic conditions.

Cell Reprogramming: True Age Reversal Technology

A gene manipulation technique called cellular programming extends the lifespan of mice and reverses signs of aging in multiple studies, leading to large financial investments in this new technology.  


A stem cell visualized under the microscope with fluorescence. (shutterstock.com | DrimaFilm)

Aging &amp; Longevity

Models: Nematodes, fruit flies, C57BL/6 mice, human umbilical vein endothelial cells, human fetal lung (IMR90) cells, whole human blood
Dosage: Dietary restriction encompassed feeding mice 70% of the amount of food consumed under ad libitum conditions for four weeks

German Study: Calorie Restriction Reverses Fast and Clumsy DNA Reading During Aging

New research shows that the pace of DNA reading (transcription) increases with age to adversely impact protein quality, but calorie restriction reverses this malfunction.

Calorie restricted diets reverse the age-related DNA reading (transcription) acceleration that facilitates clumsy and error-prone protein production.

Model: Young (8 months) and older (19 months) male and female C57/B6 mice ; 2-month old male and female rTg4150 mice &#8211; model of tau pathology 
Dosage: 3TC via drinking water (2mg/mL) for six weeks

Powerful Antiviral Drug Protects Against Memory Decline, New Study Reveals 

Researchers show that the antiviral drug 3TC mitigates age-related cognitive dysfunction and brain inflammation in naturally aged mice and transgenic mice modeling neurodegeneration.  


Search Result: Transcription

Manipulating Aging through Cutting-Edge Gene Therapies

Sirtuin Modulating Compounds: Influencing the Function of Key Proteins for Longevity

The Emergence of Cellular Reprogramming: True Age Reversal Technology

Latest German Study: Calorie Restriction Reverses Fast and Clumsy DNA Reading During Aging

New Study Reveals Antiviral Drug Protects Against Memory Decline