Will Interventions that Delay Aging in Animals Work for Humans?

Researchers have shown that using certain agents targeting hallmarks of aging (like inflammation) can extend lifespan in mice, yet human trials are just beginning to uncover whether they work in humans.

(Aged individuals may benefit from aging interventions that work in animal models | NAD.com)

Aging &amp; Longevity

The potential pitfalls of boosting NAD+ levels with NR, NMN, niacin, and nicotinamide are discussed. 

Some of the lesser known potential side effects of NAD+ precursors like NR and NMN. 

David Sinclair’s 2024 Anti-Aging Supplement Protocol

Longevity expert Dr. David Sinclair's 2024 anti-aging protocol includes NMN, fish oil, lipoic acid, resveratrol, metformin, spermidine, and more.

How exposure to microplastics — microscopic bits of plastic — could accelerate reproductive and cardiovascular aging. 


Images adapted from Zhou et al., 2023 (top) and Chen et. al, 2023 (bottom). 

Microplastics, tiny plastic particles found everywhere from your coffee cup to the air you breathe, could be making you age faster. 

<p>Model: 27-month-old male C57BL/6N mice </p>
<p>Intermittent Dosing (oral): 1 week of 100 mg/kg/day of fisetin, followed by 2 weeks of no intervention, followed by 1 week of 100 mg/kg/day of fisetin</p>


Fisetin supplementation counteracts artery aging in old mice by preserving artery elasticity and function via senolytic action — removal of senescent (dysfunctional) cells.  


Lead investigator Sophia Mahoney | University of Colorado Boulder

Search Result: senolytic supplementation

Will Interventions that Delay Aging in Animals Work for Humans?

Are There Hidden Dangers to Taking NAD+ Supplements?

David Sinclair’s 2024 Anti-Aging Supplement Protocol

Microplastics: How Your Drinking Cup Could Be Aging You Faster

Senolytic Compound Fisetin Preserves Artery Wall Elasticity to Combat Cardiovascular Disease