Model: 3-month-old LDLR−/− pigs
Dosage: 400 nM of SWNT or SWNT-SHP1i 
was infused intravenously for ~15–30 min, once a week, for 12 weeks

“Trojan Horse” Nanoparticles: A Breakthrough in Treatment for Atherosclerosis 

Stanford School of Medicine researchers develop safe nanoparticles that target dying cells in atherosclerotic plaque and reduce vascular inflammation.

Cardiovascular

Biotech Startup Aims to Harness New NAD+-Related Drug Against Aging

The longevity biotech company, MetaShape, has a new compound designed to restore cellular nicotinamide adenine dinucleotide (NAD+) and offset elevated cholesterol, cognitive decline, and neurodegeneration.

Supplementing with ergothioneine — a compound found in lion’s mane mushrooms — enhances the verbal memory of elderly individuals. 

(Image: marthastewart.com) Lion’s mane mushrooms.

Betaine Supplement Prevents Age-Related Loss of Muscle Size and Strength

Betaine prevents loss of muscle mass and strength while enhancing autophagy in old mice.

Skin &amp; Muscle

New Study Shows How Boosting NAD+ Could Protect Against Parkinson’s

Recent research from Zhejiang University School of Medicine in Hangzhou, China, demonstrates that administering NAD+ precursors to mice can safeguard the brain against neurodegeneration

(Zhejiang University School of Medicine | Panda Admission)

Brain &amp; Neurons

Model: Male Wistar rats (4-month-old young rats and 24-month-old old rats)
Dosage: Oral administration of the trypsin inhibitor tranexamic acid in drinking water for 14 days at a minimum dose of 0.39 g/kg/day after consuming about 40 mL/day of water

Newly Proposed Aging Mechanism: Digestive Enzymes May Be Eating Us from Within

University of California, San Diego researchers show digestive enzyme leakage from the intestines contributes to organ damage in old rats, offering what may be a new way to explain aging.

(Principal investigator, Geert Schmid-Schönbein | voiceofsandiego.org)

Aging &amp; Longevity

Stem cell therapy improves the reproductive potential of monkeys, with one aged monkey becoming pregnant.

(Image: labroots.com) Cynomolgus monkeys. 

Others

A molecule found in the plasma of exercised mice reverses the brain aging of sedentary mice. 

(Image: UCSF.edu) Senior author Saul Villeda, PhD. 

Model: 40 aged patients with COPD with an average age of 71.9 
Dosage: One gram of NR taken twice daily for a total of two grams per day for six weeks

Fresh Insights: NR’s Effects on Inflammation in Age-Related Lung Disease

Taking nicotinamide riboside (NR) is tied to a 52.6% reduction of an inflammatory protein in the sputum—mucus coughed up from the respiratory tract—of patients with chronic obstructive pulmonary disease (COPD).

(Principal investigator Dr. Morten Scheibye-Knudsen, Associate Professor from the University of Copenhagen | Videnskab DK)

Model: C57BL/6J mice
Dosage: 500 mg/kg/day of Urolithin A in food

Supplementing with urolithin A prevents age-related hearing loss and mitochondrial dysfunction in mice. 

“Trojan Horse” Nanoparticles: A Breakthrough in Treatment for Atherosclerosis

Biotech Startup Aims to Harness New NAD+-Related Drug Against Aging

Ergothioneine Longevity Supplement Enhances Verbal Memory

Betaine Supplement Prevents Age-Related Loss of Muscle Size and Strength

New Study Shows How Boosting NAD+ Could Protect Against Parkinson’s

Newly Proposed Aging Mechanism: Digestive Enzymes May Be Eating Us from Within

Stem Cells Prolong the Reproductive Lifespan of Aging Monkeys, New Study Shows

Scientists Identify a Molecule that Mimics the Anti-Aging Effects of Exercise on the Brain

Fresh Insights: NR’s Effects on Inflammation in Age-Related Lung Disease

Urolithin Anti-Aging Supplement Prevents Hearing Loss, New Research Shows