Cognitive deficits were reduced by 52% in Alzheimer’s disease patients receiving transcranial magnetic stimulation (TMS) — a technique that stimulates the brain’s electrical activity. 


Lead researcher Giocomo Koch, MD, PhD, uses a TMS device on an individual wearing an electroencephalogram (EEG) cap (image: domussantarita.it). 

Brain &amp; Neurons

The most comprehensive brain model reveals that combining NAD+ (nicotinamide adenine dinucleotide) supplementation with diet and exercise powerfully modulates brain aging. 


Model: Type 2 diabetic rats induced by high-fat diet and low-dose streptozotocin (STZ) Dosage: 0.2 mg/kg liraglutide administered daily for 8 weeks

Weight Loss Drug Protects Against Diabetic Sarcopenia: New Study Finds

Researchers show that liraglutide protects muscle from diabetes-induced atrophy by reversing cellular aging and activating the YAP/TAZ signaling pathway.

Diabetes &amp; Obesity

Longevity Fanatic Bryan Johnson’s Daily Aging Intervention Routine for 2025

Aging guru Bryan Johnson shares his latest daily longevity protocol, which he uses to optimize measurements of his body’s aging.

(A futuristic image of Bryan Johnson | YouTube)

Venture capitalist and aging guru Bryan Johnson reveals his latest longevity-focused daily routine for 2025, focusing on sleep, exercise, and eating well.

Aging &amp; Longevity

The longevity gene klotho prolongs the lifespan of mice while preventing muscle, bone, and brain aging. 

Miguel Chillón, PhD, and Laura Rodriguez-Estevez, researchers from Universitat Autònoma de Barcelona in Spain, who conducted the study (image: uab.cat) 

Model: Male C57BL/6 mice 
Dosage: 10 mg/kg of glyburide via intragastric injections or 500 mg/kg of NMN by oral water supply daily starting at 12 months of age until death

Common Diabetes Medication Extends Life, Suggests New Study

Researchers show that glyburide, an anti-diabetes drug, extends lifespan and reduces frailty in naturally aged mice.

(The chemical structure of glyburide, a diabetes medication | PubChem)

Older adults with LDL cholesterol levels above 130 mg/dL live longer than older adults with LDL cholesterol levels below 130 mg/dL. 

The participants of the study were from Sardinia, Italy (image: businessinsider.com). 

Metabolism

Multi-Nation Expert Panel Agrees On Biomarkers of Aging

For the first time, a multi-nation panel of aging experts reached a consensus to designate markers of aging, which could make aging intervention testing easier.

(An aged individual holding pills and supplements meant to work against aging | UCLA)

Model: 10-month-old and 22-month-old naturally aged mice / Rats with Partial Discectomy (PDE)-induced Temporomandibular Joint Osteoarthritis (TMJOA).
Dosage: 0.25% αKG and  0.75% αKG
&nbsp;

Longevity Compound Thwarts Age-Related Joint Degeneration

Researchers found that alpha-ketoglutarate (αKG) can treat osteoarthritis by preserving cartilage and reducing joint inflammation. 

Skin &amp; Muscle

Dr. Sinclair and collaborators show that an age-reversal technology that rejuvenates cells protects neurons from inflammation and cell death in mice. 

Jumpstarting the Brain Reduces Alzheimer’s Progression by 52% in New Phase II Trial.

Most Comprehensive Study Places NAD+ at Forefront of Countering Brain Aging

Weight Loss Drug Protects Against Diabetic Sarcopenia: New Study Finds

Longevity Fanatic Bryan Johnson’s Daily Aging Intervention Routine for 2025

One-Time Anti-Aging Gene Therapy Treatment Prolongs Life by 20%, New Study Shows

Common Diabetes Medication Extends Life, Suggests New Study

New Study Shows People with Higher Cholesterol Live Longer than People with Lower Cholesterol

Expert Panel Agrees On Biomarkers of Aging for Testing Therapeutics

Longevity Compound Thwarts Age-Related Joint Degeneration

Age-Reversal Tech Protects Against Neurodegeneration in Latest David Sinclair Study