Older adults with LDL cholesterol levels above 130 mg/dL live longer than older adults with LDL cholesterol levels below 130 mg/dL. 

The participants of the study were from Sardinia, Italy (image: businessinsider.com). 

Metabolism

Multi-Nation Expert Panel Agrees On Biomarkers of Aging

For the first time, a multi-nation panel of aging experts reached a consensus to designate markers of aging, which could make aging intervention testing easier.

(An aged individual holding pills and supplements meant to work against aging | UCLA)

Aging &amp; Longevity

Model: 10-month-old and 22-month-old naturally aged mice / Rats with Partial Discectomy (PDE)-induced Temporomandibular Joint Osteoarthritis (TMJOA).
Dosage: 0.25% αKG and  0.75% αKG
&nbsp;

Longevity Compound Thwarts Age-Related Joint Degeneration

Researchers found that alpha-ketoglutarate (αKG) can treat osteoarthritis by preserving cartilage and reducing joint inflammation. 

Skin &amp; Muscle

Dr. Sinclair and collaborators show that an age-reversal technology that rejuvenates cells protects neurons from inflammation and cell death in mice. 

Brain &amp; Neurons

Stop Fast Aging! New Research Suggests Protecting One Organ Helps All

Researchers from University College London unveil data suggesting that accelerated aging in certain organs increases the risk of age-related diseases across other organs.

(University College London | The Independent)

The cutoff for vitamin B12 deficiency is too low, according to new findings showing that “normal” B12 levels are associated with neurological deficits in older adults. 


Senior investigator, Ari Green, MD (image: ucsfhealth.org). 

Stanford Study: Infusing Aged Surgery Patients with Young Plasma Reduces Inflammation

In a first proof of principle human trial, researchers demonstrated that plasma proteins from young donors lower inflammatory markers in elderly people who underwent surgery.

Clinical Trials

Participants: Middle-aged adults carrying two copies of the APOE4 gene 
Dosage: 1 mg/kg/day of rapamycin for 4 weeks

The prescription drug rapamycin a.k.a. sirolimus, an FDA-approved mTOR inhibitor, increases the brain volume of cognitively normal individuals at risk for developing Alzheimer’s disease. 


One of the study’s investigators, Talissa Altes, M.D. (Image: Missouri.edu).

Esteemed Cardiologist Says Commercial Interests Are Distorting Evidence Behind Statins

Dr. Aseem Malhotra, a cardiologist from the UK, says pharmaceutical company-sponsored research distorts the scientific evidence behind the effectiveness of cholesterol-lowering statins against heart disease.

(Dr. Aseem Malhotra, cardiologist | The Telegraph)

Cardiovascular

Participants: Physically active and healthy older adults 
Dosage: 1 gram of omega-3s (330 mg EPA plus 660 mg DHA) per day, 2,000 IU of vitamin D per day, and 30 minutes of strength training exercises three times per week

While omega-3 supplementation slows biological aging, adding vitamin D and exercise further slows biological aging.

The “father of aging clocks” and senior study author Steve Horvath, PhD, of Harvard University (Image: quantamagazine.org). 

New Study Shows People with Higher Cholesterol Live Longer than People with Lower Cholesterol

Expert Panel Agrees On Biomarkers of Aging for Testing Therapeutics

Longevity Compound Thwarts Age-Related Joint Degeneration

Age-Reversal Tech Protects Against Neurodegeneration in Latest David Sinclair Study

Stop Fast Aging! New Research Suggests Protecting One Organ Helps All

You May Not Be Getting Enough Vitamin B12, Latest Study Finds Recommended Dose Is Wrong

Stanford Study: Infusing Aged Patients with Young Plasma Reduces Inflammation After Surgery

Neurodegeneration Reversed with mTOR Inhibitor Drug in New Alzheimer’s Study

Self-Proclaimed Activist and Cardiologist Says Commercial Interests Are Distorting Evidence Behind Statins

Harvard Study Reveals that Omega-3s, Vitamin D, and Exercise Additively Slow Biological Aging