Model: 40 aged patients with COPD with an average age of 71.9 
Dosage: One gram of NR taken twice daily for a total of two grams per day for six weeks

Fresh Insights: NR’s Effects on Inflammation in Age-Related Lung Disease

Taking nicotinamide riboside (NR) is tied to a 52.6% reduction of an inflammatory protein in the sputum—mucus coughed up from the respiratory tract—of patients with chronic obstructive pulmonary disease (COPD).

(Principal investigator Dr. Morten Scheibye-Knudsen, Associate Professor from the University of Copenhagen | Videnskab DK)

Model: C57BL/6J mice
Dosage: 500 mg/kg/day of Urolithin A in food

Supplementing with urolithin A prevents age-related hearing loss and mitochondrial dysfunction in mice. 

Brain &amp; Neurons

Bill eats intuitively while taking supplements like NAD+ (nicotinamide adenine dinucleotide) and peptides. 

Aging &amp; Longevity

Model: 16-month-old female C57BL/6 mice 
Dosage: 60 mg/kg/day of ABT-263 dissolved in drinking water for 7 days on, 7 days off, and 7 days on again

A senolytic compound and anti-cancer drug called ABT-263 accelerates ovarian aging in aged mice, suggesting it promotes infertility. 

Others

Model: 5xFAD mice
Dosage: 5-µL sprayed into each nostril at concentrations of 30 × 109/100 µL once weekly for two weeks

Exploring a Nasal Spray that Might Delay Alzheimer’s Progression by Years

Researchers use nano-sized vesicles derived from neural stem cells to preserve cognition as well as reduce brain inflammation and plaque buildup in an Alzheimer’s mouse model.

(An aged woman using an intranasal spray to avert Alzheimer's disease progression | NAD.com)

Abdominal fat is associated with a dramatic increase in the risk of early death in generally healthy older adults who are not obese. 

(Image: AARP / AHMET YARALI / GETTY IMAGES)

Metabolism

Considering that, for most of human history, the average human lifespan was 40 years, are we supposed to live beyond this age?

Studies suggest that supplementation with melatonin may slow brain aging, thereby improving cognition. 

Bruce N. Ames, PhD, reveals his 11 longevity vitamins — molecules that activate long-term health enzymes — as part of his Triage Theory of aging. 

Triage Theory is named after the assortment system the French Army used during World War I called Triage, which prioritized the treatment of injured soldiers. 

Researchers have identified government-approved drugs that are associated with a lower risk of mortality.  

Fresh Insights: NR’s Effects on Inflammation in Age-Related Lung Disease

Urolithin Anti-Aging Supplement Prevents Hearing Loss, New Research Shows

The Most Shredded 55-Year-Old Bill Maeda’s Longevity Secrets — Including Supplementing with NAD+

Which Anti-Aging Senolytic Supplement Should You Avoid?

Exploring a Nasal Spray that Might Delay Alzheimer’s Progression by Years

Abdominal Fat Increases Risk of Early Death by 365% in Non-Obese Adults

Are We Supposed to Live Past 40?

Does Melatonin Improve Cognition?

Bruce Ames’ Triage Theory & The Eleven Longevity Vitamins

Approved Drugs that Increase the Chances of Living a Longer Life