This NAD+ precursor shields the heart from injury caused by a chemotherapeutic in rats, preventing the disruption of tissue organization and blood pumping abilities.

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Woman,With,Cancer,During,Chemotherapy,Recovering,From,Illness,In,Hospital

Supplementing with NMN protects the heart against chemotherapy-induced heart complications that include disrupted tissue organization and blood pumping abilities.

Model: Sprague-Dawley rats 
Dosage: 20 mg/kg NAD+ by intravenous injection

Rats given intravenous NAD+ following a heart attack have improved survival, better heart function, and fewer neurological deficits.

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main

Senior author, Dr. Wanchun Tang | Exostat Medical 

Model: Male LDLR-/- mice
Dosage: 1 mg/mL in N-acetylcysteine drinking water

Potent Antioxidant Reduces Artery Cholesterol Buildup

Long-term supplementation with the antioxidant N-acetylcysteine (NAC) prevents blood vessel cholesterol accumulation in aged mice with high cholesterol.


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Liu800x450

Senior author, Dr. Zhenguo Liu | University of Missouri 

Model: female C57BL/6J mice
Dosage: 5 mg/kg Dasatinib and 50 mg/kg Quercetin intraperitoneally injected 3x per week for 4 weeks

Senolytics Promote Cardiac Regeneration in Heart Attack Model 

Italian scientists show that the senolytics Dasatinib plus Quercetin (D + Q) improve heart function and restores cardiac regenerative capacity in aged mice following myocardial infarction (heart attack). 

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Corresponding author, Dr. Daniele Torrella and team | Fame Di Sud  

Model: db/db mouse model for diabetes and obesity
Dosage (oral): 400 mg/kg/day NR for four weeks

Cardiac Dysfunction in Diabetes Reduced by NAD+ Booster 

Nicotinamide riboside (NR) – an NAD+ precursor – reduces cardiac dysfunction in diabetic mice by enhancing mitochondrial function.


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Two cells with mitochondria stained green. | Simon Troeder 

Functional Human Heart Tissue Recreated from Animal Scaffolding

Using human cells, researchers repopulate a decellularized rabbit heart which then visibly pumps.


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Picture1

Senior author, Dr. Doris Taylor | MedCity News

Model: six-month-old female C57BL/6N mice
Dosage: berberine (50 mg/kg/day) or tetrahydroberberrubine (25, 50 mg/kg/day)

Traditional Chinese Medicine Delays Cardiac Aging 

With a traditional Chinese medicine derivative called tetrahydroberberrubine (THBru), scientists delay cardiac aging in prematurely aged mice by activating mitophagy.

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An,Elderly,Indian,Man,With,Heart,Problems

Cardiovascular

C57BL/6 mice
Diet composed of rapamycin, acarbose, and phenylbutyrate

Cognitive-Boosting Cocktail Reduces Brain Senescence, Inflammation, and DNA Damage

University of Washington researchers find that the cognitive-boosting, anti-aging cocktail composed of rapamycin, acarbose, and phenylbutyrate significantly reduces brain senescence, inflammation, and DNA damage in mice. 


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senior author redo

Senior author, Dr. Warren Ladiges | UW Medicine 

Metabolism

Heart Disease Risks Linked to Napping

Analysis of over 13,000 individuals reveals that cardiovascular disease, hypertension, and stroke risks are associated with napping more than 30 minutes a day.

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wuhan unveristy of science and tech

Wuhan University of Science and Technology | Facebook Page 

C57BL/6 Mice: 3-month-old, 21-month-old
Hesperetin: 100 mg/kg/day (oral)
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New Longevity Molecule Prolongs Lifespan and Delays Cardiac and Muscle Aging 

Taiwanese researchers show that hesperetin, a compound found in many citrus plants, moderately prolongs lifespan in naturally aging mice and delays features of cardiac and skeletal muscle aging. 


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hespertin

Longevity

H9c2 Cells and Male Sprague-Dawley rats (age: 3 or 20 months)
Berberine: 5 μМ / 24 hours
Low-dose berberine: 100 mg/kg or High-dose berberine: 200 mg/kg

Berberine Shown Again to Protect Against Cardiac Aging 

Researchers confirm the cardioprotective effects of berberine and show that it works through the anti-aging protein klotho. 


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Berberine,C20h18no4,,Herbal,Alkaloid,Molecule.,Structural,Chemical,Formula,On,The

Model: male C57Bl/6 mice
Dosage/Administration: 300 mg/kg nicotinamide riboside chloride injected into abdominal cavity

Study Suggest NAD+ Precursor Reduces Stroke-Induced Brain Damage 

Chinese scientists find that the NAD+ precursor NR (nicotinamide riboside) prevents brain damage to improve learning and memory by raising NAD+ levels in a mouse model for ischemic stroke.

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Mouse Brain Slices | Cheng et al., 2022 | Neurochemical Research

Low NAD+ Now Linked to Increased Anemia in Middle-Aged Women

In a study looking at over 700 middle-aged women, scientists find that low levels of NAD+ are associated with increased rates of anemia.

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JUUL E-Cigarette Aerosols Induce Brain and Heart Inflammation 

UC San Diego researchers find that JUUL aerosols - flavored pod-based e-cigarettes - increase markers for systemic inflammation in the brain and heart of mice. 

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Boosting NAD+ Improves Features of Muscular Dystrophy 

French scientists find that by inhibiting CD38 – an enzyme that breaks down NAD+ – in a mouse model for Duchene muscular dystrophy, heart and muscle function can be improved.


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Raising NAD+ Improves Exercise Performance

By eliminating CD38 – an NAD+ consuming enzyme – scientists from Uruguay, Argentina, and the United States find that exercise performance and heart rhythms are improved in mice. 


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Preventing the breakdown of NAD+ in mice improves exercise performance and cardiac function, according to a study.

NR supplementation improves mitochondrial function and affects inflammatory response in heart failure patients

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A study indicates administering NR provides a heart failure therapy by reducing inflammation and improving cardiac function.

How Increasing NAD+ May Protect Humans From Heart Failure

NAD+ precursor decreases atrial fibrillation susceptibility and duration in mice.

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NR decreases the susceptibility for atrial fibrillation along with its duration.

Rodent Study Shows NMN Protects the Heart from Chemotherapy Toxicity

Study Shows NAD+ Protects Heart and Brain From Heart Attack

Study Shows Potent Antioxidant Reduces Artery Cholesterol Buildup

Italian Study Shows Senolytics Promote Cardiac Regeneration After Heart Attack

Scientists Reduce Cardiac Dysfunction in Diabetes by Boosting NAD+

Scientists Recreate Functional Human Heart Tissue from Animal Scaffolding

Study Shows Traditional Chinese Medicine Delays Cardiac Aging

Researchers Show Cognitive-Boosting Cocktail Reduces Brain Senescence, Inflammation, and DNA Damage

Large Study Finds Increased Risk of Heart Disease Linked to Napping

New Longevity Molecule found to Prolong Lifespan and Delay Cardiac and Muscle Aging

Study Finds Berberine Protects Against Cardiac Aging by Regulating Anti-Aging Protein

NAD+ Precursor Reduces Stroke-Induced Brain Damage, Study Finds

Study Shows Low NAD+ Associated with Increased Rates of Anemia

Study Shows JUUL E-Cigarettes Increase Inflammatory Gene Activity in the Brain and Heart of Mice

Blocking NAD+ Degradation Improves Heart and Muscle Function in Duchenne Muscular Dystrophy

Scientists find that Suppressing NAD+ Degradation Improves Exercise Performance and Prevents Abnormal Heart Rhythms in Mice

Preliminary Clinical Trial Data Shows NAD+ Improves Inflammatory Response in Heart Failure

The Nampt/NAD+ Axis may be a Potent Therapeutic Target for Individuals with Atrial Fibrillation