Diabetics Taking Metformin Increases Birth Defect Risk

NAD+ Controls Muscle Repair Clock

NAD+ Precursor Supplementation Decreases Obesity-induced Subfertility

UPenn Researchers Engineer Immune Cells that Restore Heart Function

Study Shows NAD+-Boosting Supplement Enhances Anti-Tumor Immunotherapy

NR Can Enhance T Cell Antitumor Immunity Through Mitochondrial Function Restoration

Chloroquine Extends Lifespan and Rejuvenates Multiple Organs

Embryo with Beating Heart Grown in Lab

Cellular Rejuvenation Prolongs Lifespan and Mitigates Age-Related Disease 

Tomato Compound Prevents Signs of Diabetes and Reverses Blood Vessel Aging

Eating within 8-Hour Window Elevates Beneficial Gut Bacteria Molecule

NAD+ Precursor Prevents Diet-Induced Weight Gain

Berberine Shown Again to Protect Against Cardiac Aging 

Study Suggest NAD+ Precursor Reduces Stroke-Induced Brain Damage 

Low NAD+ Now Linked to Increased Anemia in Middle-Aged Women

Bacteria from a Young Gut Reverse Age-Related Inflammation

Killer Immune Cells Supress the Root of Aging 

Potent NAD+ Booster Promotes Inflammation

Researchers discuss data challenging the proposal that NR supplementation improves the function of the cell’s powerhouse, the mitochondria, in humans.

capsule

Moore and Mucinski provide commentary on the Dollerup et al. (2020) study that did not support NR boosting NAD+ levels or improving mitochondrial function in human skeletal muscle.

A New Perspective on NR Supplementation

In the second podcast based on his book LifeSpan, Dr. Sinclair talks about the science behind how fasting and eating certain foods promote longevity.

A brief description of NAD+ intravenous therapy and the research behind it.   


Study shows that the NAD+ precursor NRH (dihydronicotinamide riboside) is more potent than other NAD+ precursors but activates genes associated with inflammation. 


The Mayo Clinic has discovered that NRH, but not other NAD+ precursors, increases NAD+ levels in immune cells, causing inflammation.

Immunity

Model: Human older adult 
Dosage: 1000 mL of plasma each week for 10 weeks

Young Blood Improves Kidney Function and Reverses Biological Age

Older adults receiving plasma from umbilical cord blood exhibit improved kidney function and decreased morbidity and mortality risk based on age-related DNA changes.


Tube of plasma (yellow) separated from blood | Lilja Malanjak (shutterstock.com)

Model: female ICR-CD1 mice 
Dosage (oral): 2 x 10^8 cfu/100µL AKK daily for one month

Probiotic Improves Longevity of Mice

Spanish scientists find that a probiotic prolongs lifespan, rejuvenates strength and coordination, and improves the immune system of old mice. 

Electron microscope image of probiotic (AKK) | Derrien et al., 2017

C57BL/6J mice (16 male; 16 female)
Diet supplemented with glycine and N-acetylcysteine (protein 23.5%, 3.0 kcal/g feed, Nacetylcysteine (NAC) 1.6 mg/g feed and glycine 1.6 mg/g feed

Antioxidant Cocktail Increases Lifespan and Attenuates Aging Hallmarks

Researchers from Baylor College show that glycine and N-acetylcysteine (GlyNAC) significantly increases mouse lifespan and improves multiple aging hallmarks. 


Model: Prematurely aged (progeria) mice 
Dosage: Tail vein injection of mTERT (mouse telomerase) lentiviral constructs

Using a therapy that extends telomeres — the DNA at the ends of our chromosomes, scientists reduce senescence in human cells and significantly prolong the lifespan of mice. 


Senior author, Dr. John Cooke with research team | Credit: Daniel Kramer, Houstonia 

Model: Genetically diverse UMHET3 mice bred from CByB6F1/J female mice and C3D2F1/J male mice (monitored first 45 days of life). 
Dosage: Chow containing encapsulated rapamycin (42 ppm of active compound) for 45 days.

Harvard Study Shows Rapamycin Increases Lifespan but Inhibits Growth

Scientists find that treating mice with rapamycin early in life moderately increases lifespan and improves physical fitness at the expense of inhibiting growth in mice. 


Author, Dr. Leonid Peshkin | Longevity.Technology 

Model: C57BL/6J mice fed 60% of calories in fat (lard)
Dosage (oral): 0.4% nicotinamide riboside in drinking water

NAD+ Booster Reduces Obesity by Altering Gut Bacteria

The NAD+ booster nicotinamide riboside (NR) reduces weight gain in mice by altering gut bacteria.

Senior author, Dr. John R. Kirby (right) with research team | Medical College of Wisconsin 

C57BL/6 mice
Diet composed of rapamycin, acarbose, and phenylbutyrate

Cognitive-Boosting Cocktail Reduces Brain Senescence, Inflammation, and DNA Damage

University of Washington researchers find that the cognitive-boosting, anti-aging cocktail composed of rapamycin, acarbose, and phenylbutyrate significantly reduces brain senescence, inflammation, and DNA damage in mice. 


Senior author, Dr. Warren Ladiges | UW Medicine 

Model: 5XFAD mice, transgenic for five familial AD (FAD) mutations
Dosage: 76% fat, 16% protein, 3% carbohydrate, and 5% dietary fiber (by calories)

Ketogenic Diet Restores Alzheimer’s Memory Deficits and Neurodegeneration

Chinese scientists find that a high-fat, low-carbohydrate diet called the ketogenic diet restores memory deficits and neurodegeneration markers in mice modeling Alzheimer’s disease. 


Model: Sprague Dawley rats 
Dosage (oral): 0.1 mg/kg chloroquine

Chinese researchers show that the anti-malaria drug chloroquine moderately extends the lifespan and rejuvenates the organs of elderly rats.

Israeli scientists successfully grow embryos with functioning hearts in a test tube using mouse embryonic stem cells. 


Senior author, Dr. Jacob H. Hanna holding synthetic embryos | eNCA, AFP/Ahmad Gharabli 

Wild-type mtKeima transgenic mice/ Wild-type C57BL/6J mice
Nicotinamide Riboside: Oral supplementation via drinking water (24 mM) for 10 months

NAD+ Booster Halts Age-Related Hearing Loss

National Institute of Aging (NIA) scientists show that NR, a precursor to the life-preserving nicotinamide adenine dinucleotide (NAD+), exerts protective effects against age-related hearing loss in mice.  


Irish researchers use viral-mediated technology to deliver genes that treat mouse and human cell models for age-related macular degeneration. 


Authors Dr. Paul Mckenna (left) and Dr. Jane Farrar (right) with colleague | siliconrepublic 

Probiotic Improves Longevity of Mice

Antioxidant Cocktail Increases Lifespan and Attenuates Aging Hallmarks

Scientists Prolong Mouse Lifespan by Extending Telomeres

Harvard Study Shows Rapamycin Increases Lifespan but Inhibits Growth

NAD+ Booster Reduces Obesity by Altering Gut Bacteria

Young Blood Improves Kidney Function and Reverses Biological Age

Cognitive-Boosting Cocktail Reduces Brain Senescence, Inflammation, and DNA Damage

Ketogenic Diet Restores Alzheimer’s Memory Deficits and Neurodegeneration

Chloroquine Extends Lifespan and Rejuvenates Multiple Organs

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Embryo with Beating Heart Grown in Lab

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