What is NAD?

Nicotinamide mononucleotide (NMN) increases blood levels of nicotinamide adenine dinucleotide (NAD+) to alleviate age-related disorders like metabolic disease and cardiovascular dysfunction.

NMN increases blood NAD+, enhances walking distance over a six-minute period, and improves a self-assessed evaluation of health, especially at higher doses in healthy adults.

NMN supplementation significantly reduces body weight, cholesterol, and blood pressure when blood fills the heart (diastolic blood pressure) in overweight or obese adults.

Supplementing with nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR) confers comparable benefits against kidney disease in male mice.

This NAD+ precursor shields the heart from injury caused by a chemotherapeutic in rats, preventing the disruption of tissue organization and blood pumping abilities.

A high but not low dose of nattokinase is associated with reducing artery plaque size by 36% in older adults.

In a major proving ground test for the longevity field, the FDA has given its approval for a human trial for a gene therapy attempting a near-total rejuvenating reset of cells.

Clinical trials show that urolithin A enhances muscle strength and reduces inflammation.

Changes to Bryan Johnson’s latest supplement stack include taking NMN or NR six days a week, rather than seven, and eliminating the use of rapamycin.

Longevity expert Dr. David Sinclair's 2024 anti-aging protocol includes NMN, fish oil, lipoic acid, resveratrol, metformin, spermidine, and more.