Researchers discuss data challenging the proposal that NR supplementation improves the function of the cell’s powerhouse, the mitochondria, in humans.

Moore and Mucinski provide commentary on the Dollerup et al. (2020) study that did not support NR boosting NAD+ levels or improving mitochondrial function in human skeletal muscle.

A New Perspective on NR Supplementation

Others

Study shows that NAD+ boosting reduces age-linked amyloid deposition and restores mitochondrial balance in muscle cells across species

A study indicates boosting NAD+ reduces age-related abnormal proteins called amyloid deposits in muscle cells and restores mitochondrial balance across species.

How to Restore Age-Related Muscle Degeneration in Human Cells | NMN

Skin &amp; Muscle

Autoimmune brain inflammation quelled with nicotinamide adenine dinucleotide (NAD+) treatment

Nicotinamide adenine dinucleotide (NAD+) treatment of rats with experimental autoimmune encephalomyelitis improved signs and symptoms of the disease.

How NAD+ May Alleviate Multiple Sclerosis in Mice

Changes in the body that come from space travel resemble growing older, providing opportunities to perform aging studies on astronauts.

Spending time in outer space can mimic the effects of aging, and scientists have begun using the unique environment of space as a place to study aging.

How Aging is Affected by Space Travel

How does The Sirtfood Diet help you live a healthier and longer life?

The Sirtfood Diet has helped celebrities like Adele lose weight and maintain their physical fitness.

How Adele Lost Weight Using Science

Metabolism

Investigators propose that a newly revealed nicotinamide adenine dinucleotide (NAD+) binding site of Sarm1 may be a promising drug target.

NAD+ binding to a region of the Sarm1 protein suppresses Sarm1 activity in promoting the degeneration of neurons.

NAD+ Inhibits Protein that Promotes Neuron Degeneration

Researchers review evidence supporting the importance of how nicotinamide adenine dinucleotide (NAD+) is distributed to different cell structures in health, disease, and aging.

Researchers review NAD+ distribution between cellular structures in health, disease, and aging. Future discoveries in NAD+ biology will come from scientists with distinct skill sets.

Subdivision of NAD+ is Critical to Mammalian Life | NMN

NR supplementation alleviates defects in cells from dyskeratosis congenita patients.

Supplementation with the NAD+ precursor, NR, improves DNA repair in the cells of patients with dyskeratosis congenita.

Replenishing NAD+ Reduces Defects in Cells with Frayed Chromosome Ends

DNA Repair

UPenn researchers identify an elusive mechanism for the entry of NAD+ into the power plant of the cell.

Scientists from UPenn identify a transporter that facilitates entry of NAD+ into mammalian mitochondria.

Scientists Identify a Mitochondrial NAD+ Transporter | NMN

Niacin improves muscle strength and fatty liver in mitochondrial myopathy patients.

Niacin increased nicotinamide adenine dinucleotide levels in blood and muscle and improved muscle strength in patients with mitochondrial myopathy.

Vitamin B3 May Raise NAD+ Levels in Human Muscle and Blood

Researchers propose that increasing NAD+ levels improves immune function in COVID-19 infection.

Researchers propose that the NAD+ molecule plays a key role in the immune response to viral infections, which include COVID-19.

NAD+ Levels May Modulate Immune Response to COVID-19

Boosting nicotinamide adenine dinucleotide (NAD+) levels restores improves circadian rhythms in old mice through youthful gene activation and metabolic patterns, revealing that NAD+ governs both behavior and metabolic health.

How NAD+ Counters Aging in the Bodies of Mice

Longevity

Niacin (vitamin B3) triggers immune cells to attack human brain tumor initiating cells.

Niacin, also called vitamin B3, stimulates immune cells to attack cells that initiate human brain tumors.

Combating Brain Cancer Using Common Vitamins

Cancer

Supplementation with the NAD+ precursor nicotinamide riboside (NR) promoted the clearance of the toxic protein that causes ALS and survival of neural stem cells in the brains of mice.

NR promotes the clearance of a toxic protein that causes ALS and increases the survival of neural stem cells in the brains of mice.

NAD+ Precursor Enhances Brain Cell Production in ALS Mice

Neurological

A long-term clinical study from Denmark showed that increased nicotinamide adenine dinucleotide (NAD+) content and improved mitochondrial function induced by nicotinamide riboside (NR) supplementation in mouse skeletal muscle does not translate into humans.

NR Does Not Improve Mitochondrial Function

Scientists review research linking variations in people’s DNA to aging.

Variations in people's DNA link to age-related diseases and aging processes in general.

Genetics and Human Aging

Excessive alcohol consumption and binge drinking reduce levels of free nicotinamide adenine dinucleotide (NAD+) critical to cellular health and energy production, resulting in liver and organ damage.

Scientists Propose that Cellular NAD+ Levels Modulate the Immune Response to COVID-19

How Does Space Travel Affect Natural Aging?

Zeroing in on the Genetics of Human Aging

Binge Drinking Causes Liver Damage by Reducing Cellular Levels of NAD+

NAD+ Keeps the Mouse Body Clock Young to Counter Aging

The Science Behind Adele’s Weight Loss

How to Restore Age-Related Muscle Degeneration in Human Cells

Common Vitamin Activates Immune Cells to Fight Off Deadly Brain Cancer

NAD+ Precursor Enhances Adult Brain Cell Production and Motor Function in ALS Mice

Scientists Identify a Mitochondrial NAD+ Transporter

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NR Does Not Improve Mitochondrial Function or NAD+ Cotent in Human Skeletal...

Replenishing NAD+ Reduces Defects in Patient Cells with Frayed Chromosome Ends

The Subdivision of NAD+ into Cell Compartments is Critical to Mammalian Life

Clinical Trial Data Shows Vitamin B3 Raises NAD+ Levels in Human Muscle and Blood

What is NAD+?

NAD+ Products

NAD+ Binds to and Inhibits a Protein that Promotes Degeneration of Neuros

New Research Shows NAD+ Alleviates Multple Slerosis in Mice

Challenging the Current Thinking on NR Supplementation