What is NAD?

Bryan Johnson debates 20 skeptics on anti-aging in Jubilee’s viral episode and challenges assumptions about lifespan, science, and the future of human health.

According to newly released results from a first-of-its-kind clinical trial, reduced nicotinamide mononucleotide (NMNH) triples circulating NAD+ and improves subjective quality of life scores.

Diallyl sulfonated compounds (DAS), found in garlic, extend the lifespan of mice while counteracting signs of aging, such as grip weakness and memory loss.

High protein intake improves the body composition of aged mice, but it lowers NAD+ (nicotinamide adenine dinucleotide) levels and promotes metabolic aging.

Boosting mitochondrial efficiency by increasing COX7RP activity extended lifespan in mice while improving energy production and reducing inflammation.

Lifestyle hacks contrived to promote the tissue density and quality of mitochondria (the cell’s powerhouses) can aid in the efficient generation of cellular energy and reduce inflammation, thereby promoting longevity.

Supplementation with vitamin B9, also known as folic acid or folate, prevents cellular senescence and slows vascular aging in naturally aged mice.

Fayoum University researchers found that cranberry polyphenols improve metabolic markers, cognition, and oxidative stress to the same degree as the drug metformin.

Elevated circulating theobromine—derived from cocoa—was associated with a slower pace of aging, according to two assessments.

Harvard and MIT scientists analyze decades of publicly available molecular studies with a new AI platform to uncover hundreds of previously hidden anti-aging strategies, like the drug ouabain.