UW Study Shows New Drug Cocktail Reverses Signs of Aging 

Turmeric Metabolite Improves Age-Related Memory Deficits

Diabetics Taking Metformin Increases Birth Defect Risk

Simple Protocol Reduces Cancer Risk by Over 60%

UPenn Researchers Engineer Immune Cells that Restore Heart Function

Study Shows NAD+-Boosting Supplement Enhances Anti-Tumor Immunotherapy

Prolonging Lifespan by 40% with Inhalation Gene Therapy 

Time-Restricted Feeding Enhances Longevity Benefits of Caloric Restriction 

Obesity Associated with Impaired Sperm Cell Development in Older Males

Medicinal Mushroom Restores Age-Related Physical Decline 

Immune Protein Improves Memory Deficits 

USC Researchers Identify Genes Controlling Brain Aging

JUUL E-Cigarette Aerosols Induce Brain and Heart Inflammation 

Boosting NAD+ Improves Features of Muscular Dystrophy 

Raising NAD+ Improves Exercise Performance

An International Forum Provides Perspectives on Therapeutics for and Mechanisms of Aging

Elysium Health™ Announces Phase II Trial for Preventing Acute Kidney Injury

How Does Space Travel Affect Natural Aging?

Researchers discuss data challenging the proposal that NR supplementation improves the function of the cell’s powerhouse, the mitochondria, in humans.

capsule

Moore and Mucinski provide commentary on the Dollerup et al. (2020) study that did not support NR boosting NAD+ levels or improving mitochondrial function in human skeletal muscle.

A New Perspective on NR Supplementation

In the second podcast based on his book LifeSpan, Dr. Sinclair talks about the science behind how fasting and eating certain foods promote longevity.

Italian scientists find that a longevity-associated variant of the BPIFB4 gene keeps NAD+ levels high in old age and may increase lifespan. 

A minor alteration in DNA sequence is linked to higher NAD+ levels and a longer lifetime, according to Italian researchers.

A brief description of NAD+ intravenous therapy and the research behind it.   


New Anti-Aging Supplement Mitopure

Using a novel anti-aging supplement, endorsed by Elon Musk’s mother, researchers characterize the microbiome of healthy individuals and replenish a longevity-linked metabolite called urolithin A. 


Model: C57BL/6 mice
Dose &#038; Administration: 14 mg/kg rapamycin, 1000 mg/kg acarbose and phenlbutryate mixed in chow

A cocktail of rapamycin, acarbose, and phenylbutyrate reduces fat, improves learning, and enhances strength and endurance in aged mice. 

Researchers from Rutgers New Jersey Medical School utilize gene therapy to increase the activity of genes - telomerase reverse transcriptase (TERT) and follistatin (FST) - known to contribute to increased lifespan (TERT) and muscle development (FST). 

Longevity

Model: older adults 
Dosage: 2000 IU Vitamin D3, 1 gram omega-3s (500 mg DHA and EPA), 
and 30 minutes of strength exercises three times a week

Swiss scientists find an association between reduced risk for cancer and combined vitamin D, omega-3 fatty acids, and exercise in older adults. 


Cancer

Model: Mouse
Dosage: 100 mg/kg sesamol
Administration: Dissolved in food

Sesame Seed Compound Prevents Weight Gain and Improves Metabolism

Chinese scientists find that sesamol treatment prevents signs of obesity, including weight gain and metabolic dysfunction, by activating AMPK and SIRT1 in middle-aged mice. 

Bacteria from a Young Gut Reverse Age-Related Inflammation

Fecal matter transplants from young mice could positively affect inflammation in the eyes, brains, and intestines of aged mice by affecting gut microbiota composition.

Gut bacteria from young mice has been shown to reverse age-related inflammation in mice.

While caloric restriction alone increases lifespan by 10%, caloric restriction within a 2-hour feeding window at night increases the lifespan of mice by 35%.  


Study shows that age-related changes in teste cells, including increased inflammation impairs sperm cell development in obese older males.


(Lukasz Pawel Szczepanski | shutterstock)

Italian researchers find that treating aged mice with Lion’s Mane (H. Erinaceus primordium) extract  boosts physical performance and improves neural oxidative stress.


5 mg/kg Dasatinib
50 mg/kg Quercetin

Senolytics Restore Muscle Building Potential in Old Age 

Scientists find that the combination of Dasatinib and Quercetin blocks age-related resistance to muscle growth in old mice and eliminates senescence cells in mouse and human muscle.

UC San Diego researchers find that JUUL aerosols - flavored pod-based e-cigarettes - increase markers for systemic inflammation in the brain and heart of mice. 

Cardiovascular

2.24 mg/kg/day rapamycin capsules

Rapamycin Mimics Dietary Restriction-Induced Brain Aging Reversal

Dietary restriction and the drug rapamycin restore nearly 70% of the same genes altered by aging in the hippocampus — the brain region associated with learning and memory — of mice. 

UW Study Shows New Drug Cocktail Reverses Signs of Aging

Prolonging Lifespan by 40% with Inhalation Gene Therapy

Simple Protocol Reduces Cancer Risk by Over 60%

Sesame Seed Compound Prevents Weight Gain and Improves Metabolism

Bacteria from a Young Gut Reverse Age-Related Inflammation

Time-Restricted Feeding Enhances Longevity Benefits of Caloric Restriction

Obesity Associated with Impaired Sperm Cell Development in Older Males

Medicinal Mushroom Restores Age-Related Physical Decline

Senolytics Restore Muscle Building Potential in Old Age

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“Longevity Gene” Revitalizes Multiple Organs and Restores NAD+

Does NAD+ IV “Drip” Therapy Work?

New Anti-Aging Supplement Mitopure

What is NAD+?

NAD+ vs NADH

JUUL E-Cigarette Aerosols Induce Brain and Heart Inflammation

Rapamycin Mimics Dietary Restriction-Induced Brain Aging Reversal

Does NAD+ IV “Drip” Therapy Work?