Diabetics Taking Metformin Increases Birth Defect Risk

NAD+ Controls Muscle Repair Clock

NAD+ Precursor Supplementation Decreases Obesity-induced Subfertility

UPenn Researchers Engineer Immune Cells that Restore Heart Function

Study Shows NAD+-Boosting Supplement Enhances Anti-Tumor Immunotherapy

NR Can Enhance T Cell Antitumor Immunity Through Mitochondrial Function Restoration

Time-Restricted Feeding Enhances Caloric Restriction 

Obesity Associated with Impaired Sperm Cell Development in Older Males

Medicinal Mushroom Restores Age-Related Physical Decline 

Sulforaphane — a Compound in Broccoli — Fights Off Fat

Using Metabolites in Saliva, Japanese Researchers Measure Aging

New Anti-Aging Supplement Mitopure

Low NAD+ Now Linked to Increased Anemia in Middle-Aged Women

JUUL E-Cigarette Aerosols Induce Brain and Heart Inflammation 

Boosting NAD+ Improves Features of Muscular Dystrophy 

Bacteria from a Young Gut Reverse Age-Related Inflammation

Killer Immune Cells Supress the Root of Aging 

Potent NAD+ Booster Promotes Inflammation

Researchers discuss data challenging the proposal that NR supplementation improves the function of the cell’s powerhouse, the mitochondria, in humans.

capsule

Moore and Mucinski provide commentary on the Dollerup et al. (2020) study that did not support NR boosting NAD+ levels or improving mitochondrial function in human skeletal muscle.

A New Perspective on NR Supplementation

In the second podcast based on his book LifeSpan, Dr. Sinclair talks about the science behind how fasting and eating certain foods promote longevity.

A brief description of NAD+ intravenous therapy and the research behind it.   


Choosing the Wrong Plant-Based Diet Can Decrease Lifespan

By monitoring over 13,000 older adults for ten years, Zhejiang University scientists find that an unhealthy plant-based diet can increase the risk of all-cause mortality by 17%. 


C57BL/6 Mice
Low-protein diet ad libitum

Study Shows Low-Protein Diet Can Extend Lifespan

Researchers from the Pennington Biomedical Research Center in Louisiana demonstrate that Fgf21 is needed to adopt the health benefits of a low-protein diet. 

Longevity

Analysis of over 13,000 individuals reveals that cardiovascular disease, hypertension, and stroke risks are associated with napping more than 30 minutes a day.

Wuhan University of Science and Technology | Facebook Page 

C57BL/6 Mice: 3-month-old, 21-month-old
Hesperetin: 100 mg/kg/day
&nbsp;

New Longevity Molecule Prolongs Lifespan and Delays Cardiac and Muscle Aging 

Taiwanese researchers show that hesperetin, a compound found in many citrus plants, moderately prolongs lifespan in naturally aging mice and delays features of cardiac and skeletal muscle aging. 


Model: C57BL/6 mice 
Dosage (oral): 5 mg/kg dasatinib and 50 mg/kg querecetin

Senolytic Combo Counters Age-Related Muscle Weakness

Mayo Clinic researchers show that the senolytics dasatinib plus quercetin (D+Q) — drugs that eliminate senescent cells — strengthen the muscles of older mice. 


Senior author, Dr. Joao F. Passos | Mayo Clinic 

4-week-old, 8-week-old, and 36-month-old Sprague Dawley rats
Lycopene: 100 mg/kg IP injection

Tomato Compound Prevents Signs of Diabetes and Reverses Blood Vessel Aging

Wuhan University researchers show that  lycopene - an antioxidant found in plants - prevents insulin resistance and promotes blood vessel growth in aged rats. 


A Vanderbilt University neuroscientist detects possible fraudulent claims regarding a landmark 2006 study, possibly uprooting a prevalent theory regarding Alzheimer’s disease progression.


NAD+ Boosting Agent Helps Prevent Brain Tumor Growth

Mitchell Cancer Institute (MCI) researchers find that elevated NAD+ levels help prevent the growth of chemotherapy-resistant brain tumor cells. 

Senior author, Dr. Robert W. Sobol | University of Southern Alabama Health 

Model: male Sprague-Dawley rats
Dosage: 5 mg/kg of honokiol (injection) or 15 mg/kg icariin (oral)

NMN and Herbal Medicines Prevent Neuron Death in Parkinson’s

Scientists report that the NAD+ precursor NMN and traditional East Asian herbal compounds icariin and honokiol prevent neuron death in a cell and animal model for Parkinson’s disease. 


Magnolia flowering plant, where honokiol can be derived (Shutterstock/Nikolay Kurzenko)

H9c2 Cells and Male Sprague-Dawley rats (age: 3 or 20 months)
Berberine: 5 μМ / 24 hours
Low-dose berberine: 100 mg/kg or High-dose berberine: 200 mg/kg

Berberine Shown Again to Protect Against Cardiac Aging 

Researchers confirm the cardioprotective effects of berberine and show that it works through the anti-aging protein klotho. 


Flu Vaccine Associated with 40% Decreased Alzheimer’s Risk 

A study of nearly 2 million older individuals shows that the influenza vaccination leads to a 40% reduction in the risk of Alzheimer’s disease. 


Senior Author,Paul E. Schulz, MD | UTHealth Houston 

Model: female C57BL/6J mice
Dosage: 300 mg/kg plasmalogens enriched in eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and other omega-3 fatty acids dissolved in drinking water.

Fat Molecules Improve Age-Related Cognitive Deficits 

Chinese scientists show that aged mice treated with fats called plasmalogens have improvements in learning and memory due to enhanced neuron generation and connectivity.


Microglia cells in aged mouse brain | Gu et al., 2022 

Eating within 8-Hour Window Elevates Beneficial Gut Bacteria Molecule

UCSD scientists find that obese mice could lose weight and lower blood sugar from a molecule secreted by their gut bacteria. 


Senior Investigator, Amir Zarrinpar, MD, Ph.D. | AASLD Foundation

B6 congenic 5XFAD 4-month-old mice
Wildtype B6 mice
100 µL F. nucleatum
&nbsp;

Gum Disease May Increase Alzheimer’s Risk

Researchers show that the oral pathogen Fusobacterium nucleatum (F. nucleatum) decreases cognitive function and exacerbates Alzheimer's features in mice modeling Alzheimer's. 

Large Study Finds Increased Risk of Heart Disease Linked to Napping

New Longevity Molecule Prolongs Lifespan and Delays Cardiac and Muscle Aging

Senolytic Combo Counters Age-Related Muscle Weakness

Tomato Compound Prevents Signs of Diabetes and Reverses Blood Vessel Aging

Falsified Data Could Set Alzheimer’s Research Back 16 Years

NAD+ Boosting Agent Helps Prevent Brain Tumor Growth

NMN and Herbal Medicines Prevent Neuron Death in Parkinson’s

Berberine Shown Again to Protect Against Cardiac Aging

Flu Vaccine Associated with 40% Decreased Alzheimer’s Risk

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