Turmeric Metabolite Improves Age-Related Memory Deficits

Diabetics Taking Metformin Increases Birth Defect Risk

NAD+ Controls Muscle Repair Clock

New Study Shows Senolytics Can Halt Cancer Development 

Vitamin D₃ Plus Omega-3 Linked to 60% Lower Cancer Risk

UPenn Researchers Engineer Immune Cells that Restore Heart Function

Harvard Study Links Severe COVID-19 to Gene Activity Signatures of Accelerated Brain Aging

Removing Senescent Immune Cells Prevents Cognitive Decline: Mayo Clinic

Fasting-Mimicking Diet Reduces Alzheimer’s Pathology

NAD+ Boosting Enzyme Protects Against Diabetes & Muscle Decline

Tomato Compound Prevents Signs of Diabetes and Reverses Blood Vessel Aging

Eating within 8-Hour Window Elevates Beneficial Gut Bacteria Molecule

Functional Human Heart Tissue Recreated from Animal Scaffolding

Traditional Chinese Medicine Delays Cardiac Aging 

Cognitive-Boosting Cocktail Reduces Brain Senescence, Inflammation, and DNA Damage

 NAD+ Nanoparticles Increase Survival from Sepsis by Over Fourfold 

Researchers Find Blocking Gut Metabolite   Prevents Cognitive Decline

Study from Sweden Suggests Nerve Stimulation Device Could Slow Aging

Researchers discuss data challenging the proposal that NR supplementation improves the function of the cell’s powerhouse, the mitochondria, in humans.

capsule

Moore and Mucinski provide commentary on the Dollerup et al. (2020) study that did not support NR boosting NAD+ levels or improving mitochondrial function in human skeletal muscle.

A New Perspective on NR Supplementation

In the second podcast based on his book LifeSpan, Dr. Sinclair talks about the science behind how fasting and eating certain foods promote longevity.

A brief description of NAD+ intravenous therapy and the research behind it.   


NAD Drip Therapy | How Does it Work | Why is it Popular?

Supplementing with the NAD+ precursor NR (nicotinamide riboside) enhances exercise performance and reduces oxidative stress in older but not younger men. 


According to a study, increasing NAD+ levels with NR decreases oxidative stress and improves exercise performance in older men, but not in younger men.

Scientists extend the lifespan of naturally aged mice while reducing age-related deficits using gene therapy-mediated genetic reprogramming.  

Model: C57BL/6J mice
Dosage: 300 mg/kg intraperitoneal injection at 22 months of age

Washington University Study: NMN Restores NAD+ in an Age-Modulating Brain Region

NMN replenishes faltering NAD+ levels in a brain region called the hypothalamus, a region that may control aging-associated processes.

(The study’s principal investigator, Shin Ichiro-Imai, MD, PhD | mspremium.com)

NAD+ levels falter in a brain region that controls sleep, appetite, thirst, and parental behavior, but NMN and/or vesicles containing the NMN-synthesizing enzyme NAMPT replenish NAD+.

German scientists find that genetic reprogramming — a rising technology that reverts cells to an earlier stage of development — improves heart regeneration after heart attack in mice. 


Max Planck Institute for Heart and Lung Research

Model: C57BL/6J mice 
Dosage: 300 mg/kg of alpelisib in food beginning at 12 months of age until death

The Nature Aging study supports the need for clinical tests of how adding alpesilib to diets affects longevity and aging.

Lead author, Dr. Chris Hedges | University of Auckland 

A study published in Nature by the University of Minnesota shows that the same lineage of mouse immune cells can continually divide over multiple lifespans.

Scientists cause mice to age by inducing epigenetic changes — changes in gene activation that don’t affect the genetic code (DNA sequence), a process that can be reversed. 


Senior author, Dr. David Sinclair | Portrait by Ken Richardson, Boston Magazine  

Model: Humans with an average age of 40 years
Dosage: Initial 250 mg of NR per day increased by 250 mg per week so that 1 gram per day of NR was reached by the end of the first month; 1 gram per day of NR for the remainder of the five-month study duration

NAD+ Supplement Increases Muscle Mitochondria: Finland Study

The supplement NR raises blood NAD+ and muscle mitochondria levels while improving the gut’s bacterial composition in humans.

(The Study’s Principal Investigator, Eija Pirinen | wiki.oroboros.at)

NR supplementation over a five-month period more than doubles blood NAD+, increases muscle mitochondrial biogenesis, and improves gut microbial composition.

Model: Female C57BL/6 mice 
Dosage: Fasting every-other-day

Scientists find that intermittent fasting – fasting every other day – increases mouse litter size and raises NAD+ in aged mouse eggs (oocytes).

From left to right: young, aged, and aged + intermittent fasting mouse egg cells stained with a green marker for cell death.

Model: C57Bl6 young and aged mice
Dosage: 25 mg/kg/day CASIN via IP injection; 4 day treatment

Rejuvenated Stem Cells Prolong Lifespan and Increase Muscle Fitness

Spanish scientists find that drug-induced stem cell rejuvenation improves muscle strength and size while significantly increasing the lifespan of mice.


Senior author, Dr. M. Carolina Florian | Bellvitge Biomedical Research Institute

Skin &amp; Muscle

A summary of the effects of boosting NAD+ with its precursors on human aging.


Nicotinamide riboside (NR, left) and nicotinamide mononucleotide (NMN, right), the most well-studied NAD+ precursors. 

Model: C57BL/6J mice
Dosage: 400 mg/kg of NR by oral gavage

New Study Shows NAD+ Supplement Improves Alcohol-Induced Intestinal Dysfunction

Alcohol degrades protein complexes – tight junctions – in the intestines that block bacteria and toxic metabolites from crossing into blood circulation, yet nicotinamide riboside (NR) restores them in mice.

(Alcohol-treated mice (middle column) have less intestinal tight junction proteins (brown dots) than healthy mice (left column), yet NR restores alcohol-induced tight junction degradation (right column) | Li et al., 2022 | Nutrients)

Excess alcohol consumption degrades the intestinal lining, leading to harmful bacteria and metabolites entering the circulatory system, yet NR counters this effect.

Others

Model: Female Sprague-Dawley rats
Dosage: L-serine: 1,000 mg/kg/day by oral gavage; N-acetyl cysteine: 300 mg/kg/day by oral gavage; L-carnitine tartrate: 100 mg/kg/day by oral gavage; Nicotinamide riboside: 120 mg/kg/day by oral gavage

NAD+- and Metabolism-Boosting Formula Aids Neurodegenerative Diseases: British Study

Combining the NAD+ precursor NR with other metabolic activating compounds restores physical function and alleviates brain tissue death in rat models of neurodegenerative disease.

A combination of metabolic activators, including the NAD+ precursor NR, act synergistically to preserve brain tissue and improve physical function in rat models of neurodegenerative disease.

Washington University Study: NMN Restores NAD+ in an Age-Modulating Brain Region

Age-Reversing Technology Promotes Heart Repair After Heart Attack: German Study

FDA-Approved Insulin Inhibitor Extends Mouse Lifespan 10%

Immune Cells Can Avoid Aging to Produce Progeny 30,000x the Earth’s Volume

Harvard Study Supports David Sinclair’s Theory: Altered Gene Programming is Root Cause of Aging

NAD+ Supplement Increases Muscle Mitochondria: Finland Study

Study Shows Intermittent Fasting Delays Reproductive Aging and Promotes Fertility

Rejuvenated Stem Cells Prolong Lifespan and Increase Muscle Fitness

NAD+ Precursors and Aging

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New Study Shows NAD+ Supplement Improves Alcohol-Induced Intestinal Dysfunction

Study Suggests We are Now Closer to Reversing Aging via Gene Therapy

NAD+- and Metabolism-Boosting Formula Aids Neurodegenerative Diseases: British Study