Turmeric Metabolite Improves Age-Related Memory Deficits

Diabetics Taking Metformin Increases Birth Defect Risk

NAD+ Controls Muscle Repair Clock

Vitamin D₃ Plus Omega-3 Linked to 60% Lower Cancer Risk

UPenn Researchers Engineer Immune Cells that Restore Heart Function

Study Shows NAD+-Boosting Supplement Enhances Anti-Tumor Immunotherapy

Vitamin B₃ Alleviates Diabetes-Induced Eye Degeneration 

Pearl Extract Rejuvenates Aged Brain and Skin

Falsified Data Could Set Alzheimer’s Research  Back 16 Years

Cellular Rejuvenation Prolongs Lifespan and Mitigates Age-Related Disease 

NAD+ Boosting Enzyme Protects Against Diabetes & Muscle Decline

Tomato Compound Prevents Signs of Diabetes and Reverses Blood Vessel Aging

Traditional Chinese Medicine Delays Cardiac Aging 

Cognitive-Boosting Cocktail Reduces Brain Senescence, Inflammation, and DNA Damage

Heart Disease Risks Linked to Napping

Study from Sweden Suggests Nerve Stimulation Device Could Slow Aging

Bacteria from a Young Gut Reverse Age-Related Inflammation

Killer Immune Cells Supress the Root of Aging 

Researchers discuss data challenging the proposal that NR supplementation improves the function of the cell’s powerhouse, the mitochondria, in humans.

capsule

Moore and Mucinski provide commentary on the Dollerup et al. (2020) study that did not support NR boosting NAD+ levels or improving mitochondrial function in human skeletal muscle.

A New Perspective on NR Supplementation

In the second podcast based on his book LifeSpan, Dr. Sinclair talks about the science behind how fasting and eating certain foods promote longevity.

A brief description of NAD+ intravenous therapy and the research behind it.   


NAD Drip Therapy | How Does it Work | Why is it Popular?

Supplementing with the NAD+ precursor NR (nicotinamide riboside) enhances exercise performance and reduces oxidative stress in older but not younger men. 


According to a study, increasing NAD+ levels with NR decreases oxidative stress and improves exercise performance in older men, but not in younger men.

Removing Senescent Immune Cells Prevents Cognitive Decline: Mayo Clinic

A Mayo Clinic study shows that clearing senescent (aged) immune cells from the brains of mice helps prevent executive functioning deterioration and memory loss.

Co-author, Dr. E. Aubrey Thompson | Play for P.I.N.K. 

Nicotinamide Riboside (NR) – an NAD+ precursor – which has been shown to positively affect age-related changes, was found to affect secondary cancer growth (metastases) using a newly developed biosensor.


Senior Author, Dr. Elena Goun | E. Budnikova, Nature Methods 

Model: C57BL/6J Mice
Dosage: 20 ug of sEVs’ protein on days 1 and 14 of experiment

Particles Secreted from Stem Cells Significantly Reduce Aging

University of Valencia researchers use small vesicles (sEVs) derived from young stem cells (ADSC) to reduce frailty, regulate inflammation, and lower senescence - a critical dormant state of cell-cycle arrest that drives aging. 


Senior author, Dr. Consuelo Borras | INCLIVA

Longevity

Model: C57BL6/J
Dosage: 300 mg/kg/day of NMN in drinking water

NMN Protects Against Intestinal Damage Induced by Cancer Radiotherapy

The NAD+ precursor nicotinamide mononucleotide (NMN) reduces intestinal injury induced by radiation exposure and largely restores gut bacteria diversity in mice. 


(Cross-section of the intestine | Joan Carles Juarez, shutterstock)

Model: Male LDLR-/- mice
Dosage: 1 mg/mL in N-acetylcysteine drinking water

Potent Antioxidant Reduces Artery Cholesterol Buildup

Long-term supplementation with the antioxidant N-acetylcysteine (NAC) prevents blood vessel cholesterol accumulation in aged mice with high cholesterol.


Senior author, Dr. Zhenguo Liu | University of Missouri 

Model: C57BL/6NCrl
Dosage: 85% of ad libitum diet fed in tablet form

University of Arizona Study Shows Moderate Calorie-Restricted Diet Improves Metabolism and Physical Function

Reducing daily calorie intake by 15% over a lifetime enhances insulin sensitivity and improves physical parameters like grip strength in mice.

A lifelong moderate reduction in calorie intake improves metabolism and physical function in mice.

Metabolism

Model: C57BL/6J mice
Dosage: alpha lipoic acid (20.19%), nicotinamide (57.68%), thiamine hydrochloride (4.04%), piperine (1.73%), and pyridoxamine dihydrochloride (16.36%) incorporated into modified mouse chow

Lifespan Prolonged, Blood Glucose Lowered, and Body Fat Reduced with Combo Therapy

A combination of B vitamins (B1, B3, and B6), alpha lipoic acid, and piperine significantly increases the lifespan of aged mice, lowers blood glucose, and reduces body fat. 


Senior Author, Dr. Pankaj Kapahi | Eric Luse, The Daily 

Model: Sprague-Dawley rats 
Dosage: 500 mg/kg/day nicotinamide riboside or 100 mg/kg/day metformin hydrochloride in drinking water

Metformin and nicotinamide riboside (NR) both alleviate inflammation and fibrosis (tissue scarring from damage) in multiple organs from elderly rats.

Model: female C57BL/6J mice
Dosage: 5 mg/kg Dasatinib and 50 mg/kg Quercetin intraperitoneally injected 3x per week for 4 weeks

Senolytics Promote Cardiac Regeneration in Heart Attack Model 

Italian scientists show that the senolytics Dasatinib plus Quercetin (D + Q) improve heart function and restores cardiac regenerative capacity in aged mice following myocardial infarction (heart attack). 

Corresponding author, Dr. Daniele Torrella and team | Fame Di Sud  

Model: Female C57BL/6J mice 
Dosage: 10 mg/kg by oral gavage twice weekly

Resveratrol Derivative Delays Ovarian Aging and Egg Cell Decline

With a plant-based polyphenol called THSG, scientists delay ovarian aging and egg cell decline by boosting sex hormone activity in mice. 


Jacqueline Whang-Peng, Corresponding Author 

Model: C57BL/6J mice
Dosage: 400 mg/kg nicotinamide riboside and 2.5 mg/kg Immucillin H intraperitoneally injected

Immucillin H Enhances NR's NAD+ Boosting Effect

The NAD+ boosting capabilities of nicotinamide riboside (NR) are enhanced when combined with an enzyme inhibitor called Immucillin H (Mundesine). 

Corresponding author, Dr. Mathias Ziegler (right) and colleague. |  University of Bergen

Model: db/db mouse model for diabetes and obesity
Dosage (oral): 400 mg/kg/day NR for four weeks

Cardiac Dysfunction in Diabetes Reduced by NAD+ Booster 

Nicotinamide riboside (NR) – an NAD+ precursor – reduces cardiac dysfunction in diabetic mice by enhancing mitochondrial function.


Two cells with mitochondria stained green. | Simon Troeder 

New Study Suggests NR May Be Bad for Cancer Patients

Particles Secreted from Stem Cells Significantly Reduce Aging

NMN Protects Against Intestinal Damage Induced by Cancer Radiotherapy

Potent Antioxidant Reduces Artery Cholesterol Buildup

University of Arizona Study Shows Moderate Calorie-Restricted Diet Improves Metabolism and Physical Function

Lifespan Prolonged, Blood Glucose Lowered, and Body Fat Reduced with Combo Therapy

Scientists Find Metformin and NR Comparably Limit Deterioration of Multiple Organs

Senolytics Promote Cardiac Regeneration in Heart Attack Model

Resveratrol Derivative Delays Ovarian Aging and Egg Cell Decline

Most Popular

David Sinclair: How to Change Your Diet to Live Longer

Does NAD+ IV “Drip” Therapy Work?

Clinical Study Suggests When to Start Taking NAD+ Boosters to Improve Exercise

Removing Senescent Immune Cells Prevents Cognitive Decline: Mayo Clinic

What is NAD+?

NAD+ vs NADH

Removing Senescent Immune Cells Prevents Cognitive Decline: Mayo Clinic

Immucillin H Enhances NR's NAD+ Boosting Effect

Cardiac Dysfunction in Diabetes Reduced by NAD+ Booster