Senolytics Restore Bone Healing Capacity in Older Age

Study Shows New Drug Cocktail Reverses Signs of Aging 

Turmeric Metabolite Improves Age-Related Memory Deficits

100% of Rectal Cancer Patients Cured by Immunotherapy

New Study Shows Senolytics Can Halt Cancer Development 

Simple Protocol Reduces Cancer Risk by Over 60%

Study Shows Low-Protein Diet Can Extend Lifespan

New Nasal Spray Gene Therapy Increases Lifespan by 40% 

Time-Restricted Feeding Enhances Caloric Restriction 

How B Vitamins and  Omega-3s Could Prevent Cognitive Decline

New Study Shows Type 2 Diabetes Accelerates Brain Aging

Medicinal Mushroom Restores Age-Related Physical Decline 

NAD+ Precursor Reduces Stroke-Induced Brain Damage 

Low NAD+ Now Linked to Increased Anemia in Middle-Aged Women

JUUL E-Cigarette Aerosols Induce Brain and Heart Inflammation 

An International Forum Provides Perspectives on Therapeutics for and Mechanisms of Aging

Elysium Health™ Announces Phase II Trial for Preventing Acute Kidney Injury

How Does Space Travel Affect Natural Aging?

Researchers discuss data challenging the proposal that NR supplementation improves the function of the cell’s powerhouse, the mitochondria, in humans.

capsule

Moore and Mucinski provide commentary on the Dollerup et al. (2020) study that did not support NR boosting NAD+ levels or improving mitochondrial function in human skeletal muscle.

A New Perspective on NR Supplementation

In the second podcast based on his book LifeSpan, Dr. Sinclair talks about the science behind how fasting and eating certain foods promote longevity.

A brief description of NAD+ intravenous therapy and the research behind it.   


Model: Aged male C57Bl/6 mice 
Dosage/Administration: 1 microgram/kilogram intravenous injection S100p1-G

Eliminating Gut Bacteria Molecule Prevents Cognitive Decline 

Scientists find a metabolite secreted by gut bacteria in aged mice that can be blocked to prevent cognitive deficits.

Co-Author, Dr. Xiang Zhang | University of Louisville

While caloric restriction alone increases lifespan by 10%, caloric restriction within a 2-hour feeding window at night increases the lifespan of mice by 35%.  


Model: C57BL/6J mice
Dosage: 5 mg/kg dasatinib (D) + 50 mg/kg quercetin (Q)

Scientists find that old mice treated with the senolytics dasatinib plus quercetin (D+Q) heal from bone fractures like young mice.


Dr. Lianping Xing & Her Team | University of Rochester Medical Center

BALB/c (female, 8-12 weeks) mice
Free NAD+ (20 mg/kg)
NAD+-LP-CaP (20 mg/kg)

 NAD+ Nanoparticles Increase Survival from Sepsis by Over Fourfold 

University of Wisconsin researchers utilize nano-sized fat particles (lipid nanoparticles) loaded with NAD+ to increase survival, rescue immune cells, and preserve energy production. 


Model: Older adults with varying levels of cognitive decline 
Dosage (oral): 1,700 mg DHA, 600 mg EPA, 0.5 mg B12, 1 mg B9, and 20 mg B6

Several recent studies suggest that the effectiveness of alleviating cognitive deficits with omega-3s in older adults depends on vitamin B levels. 


Model: female C57BL/6J mice fed high-fat/sugar/cholesterol diet
Dosage/Administration: 400 mg/kg/d NR in food

NAD+ Precursor Prevents Diet-Induced Weight Gain

Scientists find that nicotinamide riboside (NR) prevents weight gain, fat accumulation, elevated cholesterol, and inflammation in older female mice.   

Dr. Young-Ki Park and Dr. Ji-Young Lee | University of Connecticut

Model: male humans 
Dosage: 20 minutes of cycling to boost SIRT1 and NAD+

Australian scientists find that exercise triggers the release of vesicles (membrane-bound sacs) containing the NAD+ synthesizing enzyme NAMPT and significantly boosts NAD+ in young but not older males. 

Muscle cell containing extracellular vesicles | Chong et al., 2022

Twelve patients obtained remission for advanced rectal cancer with 6 months of immunotherapy, featuring dostarlimab (PD-1 antibody), in a Sloan Kettering and Yale collaborative Phase 2 clinical study.

Investigators Dr. Luis Diaz and Dr. Andrea Cercek (lab coats) and four successfully treated patients | Memorial Sloan Kettering Cancer Center

Stony Brook and Harvard scientists find that brain aging is accerlated by 26% in type 2 diabetes patients.  

Brain Scan of Diabetes Patient | Antal et al., 2022

Ptf1a-CreER (C57Bl6), Pdx1-Cre (C57Bl6), LSL-Kras+/G12D Mice
ABT-737: 25 mg/kg
Sulindac: 0.6 mg/ml

Israeli researchers show that the senolytic drug ABT-737 halts the development of precancerous lesions in the pancreas by eliminating senescent cells - cells that are in a permanent state of cell-cycle arrest. 


Swedish scientists find that electrical stimulation of the vagus nerve resolves (stops/ends) inflammation by increasing specialized fatty acids derived from omega-3s in mice.  


C57BL/6 Mice
Low-protein diet ad libitum

Researchers from the Pennington Biomedical Research Center in Louisiana demonstrate that Fgf21 is needed to adopt the health benefits of a low-protein diet. 

Longevity

Model: male C57Bl/6 mice 
Dosage/Administration: 300 mg/kg nicotinamide riboside chloride injected into abdominal cavity

Chinese scientists find that the NAD+ precursor NR (nicotinamide riboside) prevents brain damage to improve learning and memory by raising NAD+ levels in a mouse model for ischemic stroke.

Mouse Brain Slices | Cheng et al., 2022 | Neurochemical Research

Senolytics Restore Bone Healing Capacity in Older Age

NAD+ Nanoparticles Increase Survival from Sepsis by Over Fourfold

How B Vitamins and Omega-3s Could Prevent Cognitive Decline

NAD+ Precursor Prevents Diet-Induced Weight Gain

Exercise Boosts NAD+ in Young but not Older Adults

100% of Rectal Cancer Patients Cured by Immunotherapy

Eliminating Gut Bacteria Molecule Prevents Cognitive Decline

New Study Shows Type 2 Diabetes Accelerates Brain Aging

New Study Shows Senolytics Can Halt Cancer Development

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