A long-term clinical study from Denmark showed that increased nicotinamide adenine dinucleotide (NAD+) content and improved mitochondrial function induced by nicotinamide riboside (NR) supplementation in mouse skeletal muscle does not translate into humans.

NR Does Not Improve Mitochondrial Function

NR supplementation alleviates defects in cells from dyskeratosis congenita patients.

Supplementation with the NAD+ precursor, NR, improves DNA repair in the cells of patients with dyskeratosis congenita.

Replenishing NAD+ Reduces Defects in Cells with Frayed Chromosome Ends

Immunity

Researchers review evidence supporting the importance of how nicotinamide adenine dinucleotide (NAD+) is distributed to different cell structures in health, disease, and aging.

Researchers review NAD+ distribution between cellular structures in health, disease, and aging. Future discoveries in NAD+ biology will come from scientists with distinct skill sets.

Subdivision of NAD+ is Critical to Mammalian Life | NMN

Niacin improves muscle strength and fatty liver in mitochondrial myopathy patients.

Niacin increased nicotinamide adenine dinucleotide levels in blood and muscle and improved muscle strength in patients with mitochondrial myopathy.

Vitamin B3 May Raise NAD+ Levels in Human Muscle and Blood

Research from ​​ShanghaiTech University indicates the potential for targeting NAD+ metabolism to treat cancer more effectively.


Boosting NAD+ levels with nicotinamide supplementation in concert with CAR T immunotherapy effectively eliminates tumors in mice.

Cancer

Excessive alcohol consumption and binge drinking reduce levels of free nicotinamide adenine dinucleotide (NAD+) critical to cellular health and energy production, resulting in liver and organ damage.

Chronic Alcoholism Causes Liver Damage by Reducing NAD

DNA Repair

By looking at secreted sacs from brain cells in blood, UCSF School of Medicine researchers find abnormal levels of mitochondrial and NAD+ metabolism proteins tied to major depressive disorder.

Scientists from the University of California, San Francisco find abnormal levels of mitochondrial and NAD+-metabolism proteins linked to major depressive disorder.

Neurodegeneration

Using a novel anti-aging supplement, endorsed by Elon Musk’s mother, researchers characterize the microbiome of healthy individuals and replenish a longevity-linked metabolite called urolithin A. 


Study shows that NAD+ boosting reduces age-linked amyloid deposition and restores mitochondrial balance in muscle cells across species

(JOSE LUIS CALVO MARTIN & JOSE ENRIQUE GARCIA-MAURIÑO MUZQUIZ | iStock)

A study indicates boosting NAD+ reduces age-related abnormal proteins called amyloid deposits in muscle cells and restores mitochondrial balance across species.

How to Restore Age-Related Muscle Degeneration in Human Cells | NMN

Skin &amp; Muscle

Kat7 gene inactivation rejuvenates prematurely aging human cells and mice and promotes longevity.

CRISPR-induced KAT7 gene inactivation rejuvenates prematurely aging human cells and mice and promotes longevity.

Longevity

Researchers from 120 countries converged in an online presentation forum to discuss aging pathways and related therapeutic interventions.

Two thousand two hundred and eighty-six researchers from 120 countries converged in an online meeting to discuss aging pathways and therapeutic strategies to combat aging.

Others

Scientists uncover blood metabolic byproducts as signs of aging that may provide targets for age-related disease prevention through supplementation.

Researchers find blood metabolite markers indicative of aging and age-related diseases which may translate to identifying therapeutic supplement targets.

Basic Research

The clinical study will evaluate the effectiveness of nicotinamide riboside and pterostilbene treatment to protect the kidneys of heart surgery patients.

BASIS from Elysium Health contains pterostilbene and nicotinamide riboside, and researchers are conducting a clinical study to find whether it protects kidneys of heart surgery patients.

Elysium Health Announces Phase II Trial for Preventing Acute Kidney Injury

Study supports using resveratrol as a nutraceutical agent against neurodegeneration and Alzheimer’s disease

Study suggests resveratrol administration may protect against neurodegeneration and improve cognition in Alzheimer's mice fed a high-fat diet.

Autoimmune brain inflammation quelled with nicotinamide adenine dinucleotide (NAD+) treatment

Nicotinamide adenine dinucleotide (NAD+) treatment of rats with experimental autoimmune encephalomyelitis improved signs and symptoms of the disease.

How NAD+ May Alleviate Multiple Sclerosis in Mice

Changes in the body that come from space travel resemble growing older, providing opportunities to perform aging studies on astronauts.

Spending time in outer space can mimic the effects of aging, and scientists have begun using the unique environment of space as a place to study aging.

Study Shows NAD+-Boosting Supplement Enhances Anti-Tumor Immunotherapy

Binge Drinking-Induced Liver Damage Results From Reduced Cell NAD+ Levels

Study Links Depression to Metabolism and Aging-Related Protein Levels

New Anti-Aging Supplement Mitopure Promotes Microbiome Health

Restoring Age-Related Human Muscle Degeneration

Researchers Develop an Anti-Aging CRISPR-Based Gene Therapy

An International Forum Provides Perspectives on Therapeutics for and Mechanisms of Aging

Fluctuating Molecule Levels in the Blood May Indicate Signs of Aging

Elysium Health™ Announces Phase II Trial for Preventing Acute Kidney Injury Following Heart Surgery with NAD+ Plus Antioxidant Supplement

Resveratrol Restores Cognition (In Mice with Alzheimer’s)

Most Popular

NR Does Not Improve Mitochondrial Function or NAD+ Cotent in Human Skeletal...

Replenishing NAD+ Reduces Defects in Patient Cells with Frayed Chromosome Ends

The Subdivision of NAD+ into Cell Compartments is Critical to Mammalian Life

Clinical Trial Data Shows Vitamin B3 Raises NAD+ Levels in Human Muscle and Blood

What is NAD+?

NAD+ Products

NAD+ Binds to and Inhibits a Protein that Promotes Degeneration of Neuros

New Research Shows NAD+ Alleviates Multple Slerosis in Mice

Challenges to the Current Thinking on Supplementing with NR