In a human clinical trial, Yale scientists find that caloric restriction prevents thymus shrinkage and changes the inflammatory profile of fat tissue. 

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Bacteria from a Young Gut Reverse Age-Related Inflammation

Fecal matter transplants from young mice could positively affect inflammation in the eyes, brains, and intestines of aged mice by affecting gut microbiota composition.

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Gut bacteria from young mice has been shown to reverse age-related inflammation in mice.

Killer Immune Cells Supress the Root of Aging 

Chinese scientists find that immune cell treatment diminishes senescence — considered the root of aging — in human tissue, an effect enhanced by elevating the neurotransmitter dopamine in aged mice. 


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Potent NAD+ Booster Promotes Inflammation

Study shows that the NAD+ precursor NRH (dihydronicotinamide riboside) is more potent than other NAD+ precursors but activates genes associated with inflammation. 


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The Mayo Clinic has discovered that NRH, but not other NAD+ precursors, increases NAD+ levels in immune cells, causing inflammation.

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Absence of Transporter Protein Increases Lifespan and Improves Memory

Belgian scientists find that genetically deleting xCT – an amino acid transporter that brings cystine into and takes glutamate out of cells – in mice increases lifespan and improves memory.

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Why does NAD+ Drop During Aging?

These three interconnected cell processes perpetuate aging in a self-sustaining loop. 

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wheelchair guy

A new study shows that fisetin, a senolytic compound, reduces depression-like behavior in mice with brain inflammation.

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A senolytic medication that destroys growth-arrested brain cells is being used by Japanese researchers to treat depression in lupus patients.

Researchers suggest that supplementation with nutritional and pharmacological interventions like NR and NAM can combat coronavirus infection.

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A study indicates that supplementing with nutritional interventions like NR and NAM can mitigate the coronavirus infection.

Enhancing NAD+ levels May Boost Innate Immunity to Coronaviruses | NMN

Others

Researchers propose that increasing NAD+ levels improves immune function in COVID-19 infection.

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Flying purple virus molecules microscopic detail on abstract bright cold background.

Researchers propose that the NAD+ molecule plays a key role in the immune response to viral infections, which include COVID-19.

NAD+ Levels May Modulate Immune Response to COVID-19

Niacin (vitamin B3) triggers immune cells to attack human brain tumor initiating cells.

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Brain Tumor

Niacin, also called vitamin B3, stimulates immune cells to attack cells that initiate human brain tumors.

Caloric Restriction Decreases Inflammation in Humans

Study Shows Gut Bacteria from Young Mice Reverses Age-Related Inflammation

Dopamine Enhances Immune Cell Response Against Senescent Cells

Mayo Clinic Finds Potent NAD+ Booster Promotes Inflammatory Response

Study Shows that Deleting the Protein-Building Block Transporter xCT Increases Lifespan and Improves Memory in Mice

What Could Drive NAD+ Depletion During Aging?

Japanese Researchers Show Fisetin Alleviates Depression

Increasing NAD+ levels May Bolster Innate Immunity to Coronaviruses

Researchers Propose that Cellular NAD+ Levels Play Key Roles in the Immune Response to COVID-19

Activating Immune Cells with a Common Vitamin to Fight Off Deadly Brain Cancer