In a human clinical trial, Yale scientists find that caloric restriction prevents thymus shrinkage and changes the inflammatory profile of fat tissue. 

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Model: C57BL/6J mice and Abca1/g1-m/-m mice of both sexes and bone marrow-derived macrophages from C57BL/6J and Abca1/g1-m/-m mice
Dosage: 300 mg/kg of NMN by daily intraperitoneal injection for two weeks, 5 mg/kg of dasatinib and 50 mg/kg of quercetin by oral gavage for five consecutive days every two weeks for three months, and a 500 μM concentration of NMN for bone marrow-derived macrophages in laboratory dishes

Revitalizing Immune Cells & Eye Function: NMN Study Unveils Remarkable Findings

A new study suggests that NMN reverses an age-associated dysfunctional cellular state — senescence — in immune cells and restores eye function in an age-related eye disease mouse model.

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(An anatomical view of an eye with age-related macular degeneration | NAD.com)

NMN reverses an age-related dysfunctional state in immune cells — senescence — and improves eye function in an age-related eye disease mouse model.

<ul>
<li style="font-weight: 400;" aria-level="1">Cultured human lung fibroblasts with five types of senescence: Etoposide,  P16INK4a over-expression, KRAS, replicative, and UV</li>
<li style="font-weight: 400;" aria-level="1">Irradiated or naturally aged (24 months old) mice were treated with mock- or mNKG2D-CAR T; irradiation-accelerated mouse model of aging, wild-type C57BL/6 mice (8 to 10 weeks old)</li>
<li style="font-weight: 400;" aria-level="1">Three rhesus macaques and two cynomolgus macaques</li>
</ul>

Engineered Immune Cells Can Hunt Down and Eliminate Aging Cells

A study demonstrates that engineered immune cells can serve as potent and selective medicine for cells at the center of aging and age-associated diseases. 


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A study demonstrates that engineered immune cells can serve as potent and selective medicine for cells at the center of aging and age-associated diseases. 

Participants: Overweight women aged 64 ± 18
Dosage: 20 g of olive oil (mostly monounsaturated fat) in place of margarine in the morning

Certain Fats for Breakfast Reduce Inflammation

Older women who ate olive oil or margarine with breakfast had fewer circulating inflammatory molecules than those who ate butter, suggesting which fat is better for cardiovascular aging. 


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Immunity

An immune system enzyme called CD38 is associated with low NAD+ levels, shortened reproductive lifespan, and fertility problems in female mice.  


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Models:
<ul>
<li style="font-weight: 400;" aria-level="1">Cultured human lung fibroblasts with five types of senescence: Etoposide,  P16INK4a over-expression, KRAS, replicative, and UV</li>
<li style="font-weight: 400;" aria-level="1">Irradiated or naturally aged (24 months old) mice were treated with mock- or mNKG2D-CAR T; irradiation-accelerated mouse model of aging, wild-type C57BL/6 mice (8 to 10 weeks old)</li>
<li style="font-weight: 400;" aria-level="1">Three rhesus macaques and two cynomolgus macaques</li>
</ul>
Dosage: NKG2D-CAR T cells

Scientists Engineer Immune Cells that Can Hunt Down and Eliminate Aging Cells

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Model: HSCs derived from the bone marrow of anonymous old adults (58–77 years old); Old mice (81–84 weeks old).
Dosage: Old mice were fed with a control (black) or urolithin A (UA) supplemented (red) diet (50 mg kg/day) for 16 weeks.

Urolithin A Can Revitalize Blood Stem Cells in People and Mice, Study Finds 

This mitochondrial modulator helps old human blood stem cells grow and copy themselves more efficiently, and it also helps blood stem cells make blood and immune systems for old mice. 


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Model: Male C57BL/6 mice exposed to lipopolysaccharide (LPS) to induce septic shock
Dosage: 40 mg NAD+ (probably injected, but not clear from the publication)

NAD+ reduces inflammation and increases the survival of mice subjected to an overactive immune response known as sepsis. 


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Lead investigator Dr. Jasper Iske | LinkedIn

Discover groundbreaking insights from Harvard scientists as they unveil the incredible role of NAD+ in modulating the immune system. Explore how this powerful mechanism acts as a shield, protecting the body against inflammatory threats. Dive into the science at NAD.com/news.

Unlocking Immune Power: Harvard Scientists Reveal How NAD+ Modulates the Immune System to Guard Against Inflammatory Assault

Hiroshima and Nagasaki bombing survivors exhibit accelerated immune system aging, including reduced immune cells and higher levels of reactive oxygen species (ROS) — molecules that harm cells in excess. 


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Explore a groundbreaking Japanese study that uncovers a profound connection between atomic bomb radiation and the hastened aging of the immune system. Delve into the enduring repercussions of nuclear warfare, shedding light on the lasting impact of historical events on human health.

Japanese Study Reveals: Atomic Bomb Radiation Linked to Accelerated Immune System Aging – Unveiling Nuclear War's Lingering Effects

A study published in Nature by the University of Minnesota shows that the same lineage of mouse immune cells can continually divide over multiple lifespans.

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T cells demonstrate remarkable replication ability and longevity, surpassing their host's lifespan, with implications for cell-based therapies and aging research.

Model: D-gal artificially-aged mice
Dosage: 25 mg/kg intraperitoneal injections of C3G twice a week for 4 weeks

Plant Pigment Reduces Age-Related Inflammation and Boosts NAD+ 

The pigment cyanidin-3-O-glucoside (C3G) reduces inflammatory markers and boosts NAD+ in a mouse model for aging while reducing senescence in a cell model for aging. 

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(Elderberries contain abundant cyanidin-3-O-glucoside | Jaye Thompson)

Caloric Restriction Decreases Inflammation in Humans

Revitalizing Immune Cells & Eye Function: NMN Study Unveils Remarkable Findings

Engineered Immune Cells Can Hunt Down and Eliminate Aging Cells

Olive Oil and Margarine Beat Butter in Breakfast Battle for Reducing Inflammation: Spanish Study

Buck Institute Study Shows Low NAD+ Drives Reproductive Aging and Hinders Fertility

Scientists Engineer Immune Cells that Can Hunt Down and Eliminate Aging Cells

Urolithin A Can Revitalize Blood Stem Cells in People and Mice, Study Finds

Harvard Scientists Find NAD⁺ Protects Against Life-Threatening Inflammation

Japanese Study Links Radiation with Accelerated Immune Aging: Nuclear Power’s Lasting Impact

Immune Cells Can Avoid Aging to Produce Progeny 30,000x the Earth’s Volume

Researchers find Plant Pigment that Reduces Age-Related Inflammation and Boosts NAD⁺