In a human clinical trial, Yale scientists find that caloric restriction prevents thymus shrinkage and changes the inflammatory profile of fat tissue. 

heart

Participants: Healthy older adults 
Dosage: 1 mg/day of rapamycin for 8 weeks

Older adults taking low-dose rapamycin exhibit a reduction in senescent cells — cells that contribute to age-related diseases and a shorter lifespan. 

Associate professor at Oxford University and corresponding author on the study, Lynne S Cox, MA, PhD (image: researchgate.com).

Immunity

A Harvard-Trained Doctor’s Top 5 Anti-Aging Supplements

An aging research aficionado, Dr. Josh Helman, shares five supplements that can help fight the effects of aging: nitric oxide, NMN, honokiol, modified citrus pectin, and creatine.

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Josh Helman

(Harvard-trained aging expert, Dr. Josh Helman | Jupiter Medical Center)

Harvard-trained aging expert Dr. Josh Helman unveils his top five supplements to fight against aging.

Aging &amp; Longevity

In a randomized clinical trial, active and healthy older adults who took a multi-supplement and omega-3 fatty acids saw a reduction in age-related chronic inflammation after 12 weeks. 

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Inflammaging_Off

While improving immune health, the NAD+ (nicotinamide adenine dinucleotide) precursor NR (nicotinamide riboside) may induce anxiety-like behavior in stressed, aged mice. 


The study was funded by the National Institute on Aging, one of the National Institutes of Health (NIH). 

A vaccine targeting an enzyme that breaks down NAD+, called CD38, counteracts signs of aging in mice. 


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Medical disposable syringe for vaccine injection and glass vial.

Discover proven anti-aging and longevity drugs that extend lifespan. Lifestyle, nutrition, sleep, exercise, and toxin avoidance, all in the best and most comprehensive guide.

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Explore the most effective longevity interventions—nutrition, fasting, sleep, exercise, and mouse-tested drugs that extend lifespan in real studies.

Longevity Prescription: Diet, Fasting, and Proven Anti-Aging Strategies

NAD+ Supercharges Immune System Recovery in Older Mice

Researchers from the University of California, Berkeley, found that young mice need NAD+ breakdown, while old mice need NAD+ boosting.

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Berkeley

Model: C57BL/6J mice and Abca1/g1-m/-m mice of both sexes and bone marrow-derived macrophages from C57BL/6J and Abca1/g1-m/-m mice
Dosage: 300 mg/kg of NMN by daily intraperitoneal injection for two weeks, 5 mg/kg of dasatinib and 50 mg/kg of quercetin by oral gavage for five consecutive days every two weeks for three months, and a 500 μM concentration of NMN for bone marrow-derived macrophages in laboratory dishes

Revitalizing Immune Cells & Eye Function: NMN Study Unveils Remarkable Findings

A new study suggests that NMN reverses an age-associated dysfunctional cellular state — senescence — in immune cells and restores eye function in an age-related eye disease mouse model.

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AMD_EYE

(An anatomical view of an eye with age-related macular degeneration | NAD.com)

NMN reverses an age-related dysfunctional state in immune cells — senescence — and improves eye function in an age-related eye disease mouse model.

<ul>
<li style="font-weight: 400;" aria-level="1">Cultured human lung fibroblasts with five types of senescence: Etoposide,  P16INK4a over-expression, KRAS, replicative, and UV</li>
<li style="font-weight: 400;" aria-level="1">Irradiated or naturally aged (24 months old) mice were treated with mock- or mNKG2D-CAR T; irradiation-accelerated mouse model of aging, wild-type C57BL/6 mice (8 to 10 weeks old)</li>
<li style="font-weight: 400;" aria-level="1">Three rhesus macaques and two cynomolgus macaques</li>
</ul>

Engineered Immune Cells Can Hunt Down and Eliminate Aging Cells

A study demonstrates that engineered immune cells can serve as potent and selective medicine for cells at the center of aging and age-associated diseases. 


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A study demonstrates that engineered immune cells can serve as potent and selective medicine for cells at the center of aging and age-associated diseases. 

Participants: Overweight women aged 64 ± 18
Dosage: 20 g of olive oil (mostly monounsaturated fat) in place of margarine in the morning

Certain Fats for Breakfast Reduce Inflammation

Older women who ate olive oil or margarine with breakfast had fewer circulating inflammatory molecules than those who ate butter, suggesting which fat is better for cardiovascular aging. 


Caloric Restriction Decreases Inflammation in Humans

New Oxford Study: Powerful Longevity Drug Rapamycin Targets Cell Senescence

A Harvard-Trained Doctor’s Top 5 Anti-Aging Supplements

New Clinical Trial: Longevity Stack Fights Age-Related Inflammation

Anti-Aging NAD+ Precursor Supplement Prevents Immune Decline, New Study Shows

Anti-Aging Vaccine Boosts Strength, Memory & NAD+ in New Study

Longevity Prescription

NAD+ Supercharges Immune System Recovery In Older Mice, Hurts Blood Stem Cells of Young Mice

Revitalizing Immune Cells & Eye Function: NMN Study Unveils Remarkable Findings

Engineered Immune Cells Can Hunt Down and Eliminate Aging Cells

Olive Oil and Margarine Beat Butter in Breakfast Battle for Reducing Inflammation: Spanish Study