The longevity gene klotho prolongs the lifespan of mice while preventing muscle, bone, and brain aging. 

Miguel Chillón, PhD, and Laura Rodriguez-Estevez, researchers from Universitat Autònoma de Barcelona in Spain, who conducted the study (image: uab.cat) 

Aging &amp; Longevity

Participants: Middle-aged adults carrying two copies of the APOE4 gene 
Dosage: 1 mg/kg/day of rapamycin for 4 weeks

The prescription drug rapamycin a.k.a. sirolimus, an FDA-approved mTOR inhibitor, increases the brain volume of cognitively normal individuals at risk for developing Alzheimer’s disease. 


One of the study’s investigators, Talissa Altes, M.D. (Image: Missouri.edu).

Brain &amp; Neurons

By reducing brain inflammation, apigenin may protect against cognitive decline associated with aging, according to research out of Colorado State University.


Explore apigenin's benefits for brain health: reducing inflammation, enhancing memory, and protecting against aging-related cognitive decline.

Model: Six to seven-year-old female sheep
Dosage: 100 mg/kg of fisetin on two consecutive days per week for eight weeks by intravenous infusion

Latest Findings: Fisetin Confers Anti-Aging Impact Against Brain Senescence

Researchers find that fisetin cuts inflammation-promoting senescent brain cells and reduces brain injury in aged sheep.

(The image shows the green fluorescence labeled senescence protein p16 and neurons labeled red with their overlapping orange coloration indicating senescent neurons in the cortex)

Explore the cutting-edge research revealing Fisetin's remarkable anti-aging effects on combating brain senescence. Discover the latest findings and their implications at NAD.com.

Unlocking the Power of Fisetin: Latest Findings on Its Anti-Aging Impact Against Brain Senescence | NAD

Model: C57BL/6 mice
Dosage: 400 mg/kg/day injected intraperitoneally for 14 consecutive days

NAD+ Precursor Nicotinamide Enhances Nerve Insulation for Rapid Electrical Signaling

Researchers uncover that nicotinamide stimulates the production of the lipid-rich multilayer membrane — myelin — that allows nerves to rapidly propagate signals in mice.

(A depiction of degenerating myelin, which insulates neurons to rapidly propagate electrical signals in the brain | News-medical.net)

Discover how a Greek study highlights the role of NAD precursor nicotinamide in boosting nerve insulation for faster electrical signal propagation. Explore the implications for nerve health and function.

Search Result: Astrocytes

One-Time Anti-Aging Gene Therapy Treatment Prolongs Life by 20%, New Study Shows

Neurodegeneration Reversed with mTOR Inhibitor Drug in New Alzheimer’s Study

Research Supports Apigenin’s Anti-Aging Benefits on The Brain

Latest Findings: Fisetin Confers Anti-Aging Impact Against Brain Senescence

NAD⁺ Precursor Nicotinamide Enhances Nerve Insulation for Rapid Electrical Signal Propagation: Greek Study