The Most Important Anti-Aging Drugs and Interventions

President and CEO of the Buck Institute for Research on Aging Eric Verdin, M.D., discusses the future of anti-aging drugs and the most important interventions to improve lifespan. 

Aging &amp; Longevity

Model: HSCs derived from the bone marrow of anonymous old adults (58–77 years old); Old mice (81–84 weeks old).
Dosage: Old mice were fed with a control (black) or urolithin A (UA) supplemented (red) diet (50 mg kg/day) for 16 weeks.

Urolithin A Can Revitalize Blood Stem Cells in People and Mice, Study Finds 

This mitochondrial modulator helps old human blood stem cells grow and copy themselves more efficiently, and it also helps blood stem cells make blood and immune systems for old mice. 


Immunity

Model: C57/B6 female mice
Dosage: 300 mg/kg of ꞵ-hydroxybutyrate intraperitoneally injected three times per week for four weeks

Intermittent Fasting Potently Suppresses Tumor Growth: New Study Findings

Researchers show that intermittent fasting — going without food for 16-hour intervals per day — reduces tumor growth and extends lifespan in mice with ovarian cancer.

(A mouse with an ovarian tumor next to a dish of food in a laboratory | NAD.com)

Intermittent fasting significantly extends remaining lifespan and suppresses tumor growth in mice with an aggressive and lethal form of ovarian cancer.

Cancer

Model: NOD/SCID mice
Dosage: 3.4 mg/kg/day of neopetroside-B injected for three consecutive days

NAD+ Boosting Neopetroside-B Protects the Heart and Suppresses Cancer

Researchers show treatment with the nicotinamide adenine dinucleotide (NAD+) precursor neopetroside-B increases heart cell survival, prevents chemotherapy-induced heart scarring, and reduces tumor volume in mice.

(The molecular structure of the NAD+ precursor neopetroside-B)

Discover groundbreaking findings from a Korean study on Neopetroside-B's remarkable role in safeguarding the heart during chemotherapy while also exhibiting cancer-suppressing properties. Learn how NAD augmentation holds promise for enhanced cancer treatments.

NAD Boosting Neopetroside-B: Protecting the Heart during Chemotherapy & Suppressing Cancer – Korean Study

Model: Human neuroblastoma (SK-N-BE(2)c), breast cancer (MDA-MB-468), and small-cell lung cancer (H82) cells; ES1e/SCID mice
Dosage: 500 nM of AOH1996 for 18 hours of cell treatment; 40 mg/kg of AOH1996 twice daily administered orally for mice

City of Hope Study Shows New Drug Kills Multiple Solid Tumors

Researchers demonstrate that an investigational small molecule selectively disrupts DNA repair and replication in cancer cells to suppress tumor growth in mice.

(The study’s principal investigator, Linda H. Malkas, PhD | Radiome.gr)

Discover the groundbreaking findings of the latest cancer study, unveiling a new chemotherapeutic agent's efficacy in targeting and killing various solid tumors. Explore the promising implications of this research at NAD.com.

Search Result: Chemotherapy

Longevity Expert Dr. Eric Verdin: The Most Important Anti-Aging Drugs and Interventions

Urolithin A Can Revitalize Blood Stem Cells in People and Mice, Study Finds

Intermittent Fasting Potently Suppresses Tumor Growth to Prolong Survival: New Study Findings

NAD⁺ Boosting Molecule Protects the Heart Against Chemotherapy and Suppresses Cancer: Korean Study

City of Hope Study Shows New Drug Kills Multiple Solid Tumors