<p>Model: C57BL/6N mice<br />
Dosage: 1 g/kg carvedilol in food for one week followed by four weeks of PAGln treatment, consisting of 50 mg/kg per day by injection, and the same PAGln treatment for four weeks followed by 50 mg/kg per day of ABT263 via oral gavage for five days</p>


New Study Suggests Combining Senolytics with Blood Pressure Medication Counteracts an Aging Gut

Carvedilol, a blood pressure medication, and the senolytic agent ABT-263 both attenuate cellular senescence—an age-related, dysfunctional cellular state—driven by a gut bacterial metabolite in mice.

Aging &amp; Longevity

How to counteract age-related gut microbe alterations through diet, lifestyle interventions, and supplements. 

Counteracting the aging microbiome with a fiber-rich diet and supplements. 

Leading aging biology expert, Morgan Levine, Ph.D., says the scientific field of aging has a “major gender balance issue.”


Dr. Morgan Levine (image: Nicole Frappier/ The Guardian)

Morgan Levine triggers a flurry of responses on Twitter/X by saying there is gender imbalance in the field of aging biology. 

Others

While certain kinds of senescent cells play roles in healing and cancer prevention, many can contribute to aging by promoting inflammation and tissue damage.

When are cells are exposed to certain stressors they become senescent cells and if our immune system can't get rid of them all, some may contribute to aging. 

Stanford-led scientists show that our organs age at different rates, and older organs can increase the risk of disease and mortality. 


Principal Investigator Dr. Tony Wyss-Coray |Stanford Medicine Facebook 

Search Result: Diversity

Combining Senolytics with Blood Pressure Medication Counteracts Gut Aging and Promotes Longevity, Suggests New Study

How to Improve Gut Microbiome Health with Age

Female Longevity Scientist Points Out Gender Imbalance in Aging Field

What Are Senescent Cells and Do They Drive Aging?

Stanford: Organ Aging Predicts Human Lifespan