Participants: Healthy adults (18 to 47 years old)
Dosage: 1 g of an NAD+ precursor, 12.35 g of L-serine, 3.73 g of L-carnitine tartrate, and 2.55 g of N-acetyl cysteine

Of five different NAD+ precursors, NMN and NR similarly reduce blood fat levels and boost NAD+ levels when combined with an antioxidant and fat-burning blend, called the combined metabolic activator (CMA), in healthy adults.  


Discover the latest international study revealing the metabolic health effects of NMN and NR formulations. Explore the similarities and benefits of these NAD+ precursors for improving overall metabolic health.

NMN and NR Formulations Exert Similar Metabolic Health Effects: Latest International Study

Metabolism

Model: 22-month-old mice 
Dosage: Approximately 100 mg/kg/day D-serine in drinking water

The amino acid D-serine is reduced in older individuals, and D-serine supplementation improves the memory of aged mice. 


The hypothalamus of the brain controls many whole-organism functions. | shutterstock.com

Brain &amp; Neurons

Model: Human patients older than 50 years with mild to moderate Alzheimer’s
Dosage: 12.35 g L-serine (61.75%), 1 g nicotinamide riboside (5%), 2.55 g N-acetyl-L-cysteine (12.75%), and 3.73 g L-carnitine tartrate (18.65%) daily for 84 days.

Study Shows Metabolic Activator Mix Reverses Cognitive Decline in Alzheimer’s Patients

Treatment with serine, N-acetyl-cysteine, carnitine tartrate, and an NAD+ booster enhanced cognitive functions in Alzheimer’s patients with severe cognitive defects.


A combination of metabolic activators shows promise in improving cognition in severe Alzheimer's patients, suggesting a new therapeutic approach.

Model: Female Sprague-Dawley rats
Dosage: L-serine: 1,000 mg/kg/day by oral gavage; N-acetyl cysteine: 300 mg/kg/day by oral gavage; L-carnitine tartrate: 100 mg/kg/day by oral gavage; Nicotinamide riboside: 120 mg/kg/day by oral gavage

NAD+- and Metabolism-Boosting Formula Aids Neurodegenerative Diseases: British Study

Combining the NAD+ precursor NR with other metabolic activating compounds restores physical function and alleviates brain tissue death in rat models of neurodegenerative disease.

A combination of metabolic activators, including the NAD+ precursor NR, act synergistically to preserve brain tissue and improve physical function in rat models of neurodegenerative disease.

Search Result: L-serine

NMN and NR Formulations Exert Similar Metabolic Health Effects: Latest International Study

Brain Aging Can be Prevented by Memory-Boosting D-serine Supplement, Chinese Study Suggests

Study Shows Metabolic Activator Mix Reverses Cognitive Decline in Alzheimer’s Patients

NAD⁺- and Metabolism-Boosting Formula Aids Neurodegenerative Diseases: British Study