Model: C57BL/6J mice
Dosage: 500 mg/kg/day of Urolithin A in food

Supplementing with urolithin A prevents age-related hearing loss and mitochondrial dysfunction in mice. 

Brain &amp; Neurons

The large-scale preclinical study shows that SRN-901 significantly extends lifespan and healthspan while improving a great number of aging parameters.


Seragon Biosciences increases the lifespan and healthspan of mice in one of the largest studies of its kind. 

Aging &amp; Longevity

Model: HSCs derived from the bone marrow of anonymous old adults (58–77 years old); Old mice (81–84 weeks old).
Dosage: Old mice were fed with a control (black) or urolithin A (UA) supplemented (red) diet (50 mg kg/day) for 16 weeks.

Urolithin A Can Revitalize Blood Stem Cells in People and Mice, Study Finds 

This mitochondrial modulator helps old human blood stem cells grow and copy themselves more efficiently, and it also helps blood stem cells make blood and immune systems for old mice. 


Immunity

Model: 24- to 26-month-old male C57BL/6J mice for heart and muscle function experiments
Dosage(oral): 50 mg/kg/day urolithin A

Urolithin A — prevalent in pomegranate — improves the heart health and muscle strength of aged mice by stimulating mitophagy — the destruction of damaged mitochondria. 

CEO of Amazentis (the company that sponsored the study), Chris Rinsch holding a pomegranate (photo: Oliver Evard). 

Discover the amazing story from the University of Washington about how Urolithin A (UA) can make your heart healthy and your muscles super strong. Get the scoop at NAD.com!

Super News: Urolithin A Makes Hearts and Muscles Super Strong! | NAD

Cardiovascular

Metabolic Regulators: Improving Energy Production and Expenditure

Metabolic modulators like rapamycin, urolithin A, acarbose, glycine and N-acetyl cysteine, and canagliflozin enhance mitochondrial function to improve metabolism to increase longevity.

(A mitochondria surrounded by a canagliflozin molecule [top left], an acarbose molecule [bottom left], and an N-acetyl cysteine molecule [bottom right])

Explore the impact of metabolic regulators on energy production and expenditure. Discover how these regulators influence cellular metabolism and potentially contribute to improved energy balance and overall health at NAD.com.

Search Result: Mitophagy

Urolithin Anti-Aging Supplement Prevents Hearing Loss, New Research Shows

Seragon’s Aging Intervention Drug SRN-901 Achieves One of the Largest Extensions of Lifespan and Healthspan to Date

Urolithin A Can Revitalize Blood Stem Cells in People and Mice, Study Finds

Urolithin A Restores Heart and Muscle Vitality, University of Washington Study

Metabolic Regulators: Extending Lifespan by Modulating Energy Production and Mitigating Cell Damage