Participants: Middle-aged adults carrying two copies of the APOE4 gene 
Dosage: 1 mg/kg/day of rapamycin for 4 weeks

The prescription drug rapamycin a.k.a. sirolimus, an FDA-approved mTOR inhibitor, increases the brain volume of cognitively normal individuals at risk for developing Alzheimer’s disease. 


One of the study’s investigators, Talissa Altes, M.D. (Image: Missouri.edu).

Brain &amp; Neurons

The story behind how the most scientifically-backed life-extending agent — rapamycin — was accidentally discovered on the world’s most isolated body of land inhabited by humans, Rapa Nui, a.k.a. Easter Island.

Easter Island’s world-famous moai monoliths. | (shutterstock.com | Stefano73)

Model: C57BL/6 mice
Dose &amp; Administration: 14 mg/kg rapamycin, 1000 mg/kg acarbose and phenlbutryate mixed in chow

Study Identifies New Age-Reversing Drug Cocktail 

A cocktail of rapamycin, acarbose, and phenylbutyrate reduces fat, improves learning, and enhances strength and endurance in aged mice. 

Age Reversed Kidney Tissue | Jiang et al., 2022 | Scientific Reports 

Dose: 14 mg/kg rapamycin
Adminisration: mixed in chow (food)

Rapamycin Extends Lifespan by Reorganizing DNA 

German and British scientists find that rapamycin, an inhibitor of mTOR, increases histone protein levels, leading to increased autophagy, improved gut health, and slightly increased lifespan in flies. 


Search Result: sirolimus

Neurodegeneration Reversed with mTOR Inhibitor Drug in New Alzheimer’s Study

Most Powerful Life-Extending Agent To-Date Discovered in Ancient Volcano Crater

University of Washington Study Identifies New Age-Reversing Drug Cocktail

Rapamycin Improves Longevity and Gut Health Through Rearrangement of DNA