Four FDA-Approved Drugs that Reduce Chances of Aging-Related Death

Dr. Nir Barzilai, the director of aging research at Albert Einstein College of Medicine, discusses the science behind SGLT2 inhibitors, metformin, bisphosphonates, and GLP-1 agonists.

Dr. Nir Barzilai, the director of aging research at Albert Einstein College of Medicine, relays that we have four FDA-approved drugs that lower human mortality: SGLT2 inhibitors, bisphosphonates, metformin, and GLP-1 agonists.

Aging &amp; Longevity

The latest scientific research indicates that both resistance and aerobic exercise are necessary for maximizing longevity and promoting overall health. 

Model: Male C57BL/6J mice fed a high-fat diet to induce obesity and insulin resistance
Dosage (oral): 400 mg/kg of NR

Supplementing obese mice with nicotinamide riboside (NR) prevents fat mass gain, lowers blood glucose levels, and alleviates insulin resistance. 


View from the top of normal (left), obese (middle), and NR-treated obese (right) mice scanned for fat (depicted in yellow) visualization.

Diabetes &amp; Obesity

NAD+ Precursors: Unlocking the Fountain of Youth by Maximizing NAD+ Levels

Nicotinamide adenine dinucleotide (NAD+) levels decline with age, which has been linked to age-related conditions, yet NAD+-boosting precursors replenish this essential molecule.

Maximizing NAD+ levels with the precursors tryptophan, nicotinic acid, nicotinamide, NMN, or NR can alleviate age-associated diseases like cardiovascular ailments and neurodegenerative conditions.

Model: 6-month-old C57BL/6J mice up to 18-months-old (12-month intervention)
Dosage: 7.3% (of total grams of food) alpha linolenic acid (ALA) in food

Lesser-Known Omega-3 Protects Against Cardiovascular Aging

Plant-based omega-3 fatty acid — alpha-linolenic acid (ALA) — prevents heart dysfunction, reduces cardiac scarring, and improves artery elasticity in aged mice. 

Principal Investigator Dr. Jürg H. Beer | Badener Tagblatt 

Search Result: weight gain prevention

Four FDA-Approved Drugs that Reduce Chances of Aging-Related Death

Engaging in Regular Physical Activity: A Key Strategy for Enhancing Longevity and Overall Health

Latest Study Shows NR Shields Against Diabetes and Curbs Fat Gain

NAD⁺ Precursors: Unlocking the Fountain of Youth by Maximizing NAD+ Levels

Swiss Study Uncovers Benefits of Lesser-Known Omega-3 in Protecting Against Heart and Artery Deterioration