UPenn researchers identify an elusive mechanism for the entry of NAD+ into the power plant of the cell.

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Mitochondria

Scientists from UPenn identify a transporter that facilitates entry of NAD+ into mammalian mitochondria.

Scientists Identify a Mitochondrial NAD+ Transporter | NMN

Basic Research

Model: Young C57BL/6J mice fed a high protein (56% of daily calories) diet for 20 weeks 
Dosage: Injection with either 400 mg/kg of NMN or 20 mg/kg of 78c for 4 weeks

High protein intake improves the body composition of aged mice, but it lowers NAD+ (nicotinamide adenine dinucleotide) levels and promotes metabolic aging. 

protein

Protein

Metabolism

Model: Male COX7RP transgenic mice with systemic overexpression of COX7RP, aged under standard laboratory conditions and compared with age-matched wild-type controls.
Dosage: Not applicable. COX7RP activity was increased via genetic overexpression rather than drug administration.

Boosting mitochondrial efficiency by increasing COX7RP activity extended lifespan in mice while improving energy production and reducing inflammation.

hourglass_mitochondria

Aging &amp; Longevity

How to Boost Mitochondrial Tissue Density and Quality for Longevity

Lifestyle hacks contrived to promote the tissue density and quality of mitochondria (the cell’s powerhouses) can aid in the efficient generation of cellular energy and reduce inflammation, thereby promoting longevity.

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mitochondria

(A colorized image of mitochondria taken with a transmission electron microscope | UC San Diego Today)

Exercise, nutritional support, and lifestyle hacks like cold exposure can all help mitigate mitochondrial dysfunction, a key hallmark of aging.

New Study Shows Cranberry Extract Equivalent to Metformin in Fighting Aging

Fayoum University researchers found that cranberry polyphenols improve metabolic markers, cognition, and oxidative stress to the same degree as the drug metformin.

cranberries

A new study suggests cranberry extract has effects against aging that rival metformin.

α-Lipoic Acid: Efficacy, Safety, and Dosage

α-lipoic acid is an antioxidant naturally produced by the body, which is also available as a supplement, and human trials indicate that it has neuroprotective and male fertility-enhancing effects.

alpha-lipoic-acid

alpha-lipoic acid

(α-lipoic acid’s molecular structure | Neuroneeds)

α-lipoic acid is a potent antioxidant, which human trials suggest has neuroprotective and male fertility-enhancing properties.

A Harvard-Trained Doctor’s Top 5 Anti-Aging Supplements

An aging research aficionado, Dr. Josh Helman, shares five supplements that can help fight the effects of aging: nitric oxide, NMN, honokiol, modified citrus pectin, and creatine.

josh-helman

Josh Helman

(Harvard-trained aging expert, Dr. Josh Helman | Jupiter Medical Center)

Harvard-trained aging expert Dr. Josh Helman unveils his top five supplements to fight against aging.

Discover proven anti-aging and longevity drugs that extend lifespan. Lifestyle, nutrition, sleep, exercise, and toxin avoidance, all in the best and most comprehensive guide.

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Explore the most effective longevity interventions—nutrition, fasting, sleep, exercise, and mouse-tested drugs that extend lifespan in real studies.

Longevity Prescription: Diet, Fasting, and Proven Anti-Aging Strategies

Model: Naturally aged C57BL/6J mice

Can Intermittent Fasting Slow Down Gut Aging? New Research Suggests So

A new study provides data suggesting compromised intestinal function with age and that fasting for short periods promotes intestinal regeneration and function in aged mice.

dysfunctional-intestines

Dysfunctional intestines

(A dysfunctional intestinal barrier that leaks harmful substances and bacteria into circulation develops with age | The Amino Company)

Alternate-day fasting, a form of intermittent fasting, reverses age-related intestinal barrier leakage in old mice.

Older adults with LDL cholesterol levels above 130 mg/dL live longer than older adults with LDL cholesterol levels below 130 mg/dL. 

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Italy

The participants of the study were from Sardinia, Italy (image: businessinsider.com). 

Abdominal fat is associated with a dramatic increase in the risk of early death in generally healthy older adults who are not obese. 

belly_fat

Belly_Fat

(Image: AARP / AHMET YARALI / GETTY IMAGES)

Mitochondrial NAD⁺ Transporter Identified

High Protein Intake Promotes Aging by Lowering NAD+ Levels

New Study Shows Increasing Mitochondrial Protein Improves Energy Production and Extends Lifespan

How to Boost Mitochondrial Tissue Density and Quality for Longevity

New Study Shows Cranberry Extract Equivalent to Metformin in Fighting Aging

An Overview of α-Lipoic Acid: Efficacy, Safety, and Dosage

A Harvard-Trained Doctor’s Top 5 Anti-Aging Supplements

Longevity Prescription

Can Intermittent Fasting Slow Down Gut Aging? New Research Suggests So

New Study Shows People with Higher Cholesterol Live Longer than People with Lower Cholesterol

New Research Study Claims Belly Fat Increases Risk of Early Death by Whopping 365%