UPenn researchers identify an elusive mechanism for the entry of NAD+ into the power plant of the cell.

mitochondria-2

Mitochondria

Scientists from UPenn identify a transporter that facilitates entry of NAD+ into mammalian mitochondria.

Scientists Identify a Mitochondrial NAD+ Transporter | NMN

Basic Research

Model: Mouse
Dosage: 100 mg/kg sesamol
Administration: Dissolved in food

Sesame Seed Compound Prevents Weight Gain and Improves Metabolism

Chinese scientists find that sesamol treatment prevents signs of obesity, including weight gain and metabolic dysfunction, by activating AMPK and SIRT1 in middle-aged mice. 

whitesesamewithwoodenspoononwhitebackgroundtopview

White,Sesame,With,Wooden,Spoon,On,White,Background,Top,View

Research from the University of Michigan and Vanderbilt University suggests that sulforaphane should be clinically evaluated for weight loss and obesity-associated metabolic disorders.

brocolli

By analyzing compounds in human saliva, Japanese researchers pinpoint a panel of metabolites indicative of aging that includes NAD+. 

dentistshandtakingsalivatestfromwomansmouthwithcotton

Dentist's,Hand,Taking,Saliva,Test,From,Woman's,Mouth,With,Cotton

Japanese researchers conduct the first comprehensive analysis of compounds in saliva and pinpoint a panel of metabolites that include NAD+ indicative of aging. 

Researchers Measure Human Aging Using Metabolites in Saliva

New Anti-Aging Supplement Mitopure

Using a novel anti-aging supplement, endorsed by Elon Musk’s mother, researchers characterize the microbiome of healthy individuals and replenish a longevity-linked metabolite called urolithin A. 


microbiome-1

microbiome (1)

How does The Sirtfood Diet help you live a healthier and longer life?

trans-pterostilbene-supplements

Trans-Pterostilbene Supplements

The Sirtfood Diet has helped celebrities like Adele lose weight and maintain their physical fitness.

How Adele Lost Weight Using Science

DNA Repair

A study from UPenn scientists shows rapamycin prevents age-related alterations of metabolic state in muscle cells, which may extend lifespan.

structure-of-the-atp-synthase-a-molecular-machine

Structure of the ATP synthase, a molecular machine

Rapamycin increases the NAD+/NADH ratio and subsequent metabolic balance by reducing NADH levels in mouse muscle.

Excessive alcohol consumption and binge drinking reduce levels of free nicotinamide adenine dinucleotide (NAD+) critical to cellular health and energy production, resulting in liver and organ damage.

Mitochondrial NAD+ Transporter Identified

Study Shows Sesamol Prevents Weight Gain and Improves Metabolism in Middle-Aged Mice

Sulforaphane — a Compound in Broccoli — Fights Off Fat

Using Metabolites in Saliva, Japanese Researchers Measure Aging

New Anti-Aging Supplement Mitopure Promotes Microbiome Health

The Science Behind Adele’s Weight Loss

Rapamycin’s Muscle Cell Metabolic Balance Improvement May Enhance Longevity

Binge Drinking-Induced Liver Damage Results From Reduced Cell NAD+ Levels