UPenn researchers identify an elusive mechanism for the entry of NAD+ into the power plant of the cell.

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Mitochondria

Scientists from UPenn identify a transporter that facilitates entry of NAD+ into mammalian mitochondria.

Scientists Identify a Mitochondrial NAD+ Transporter | NMN

Basic Research

Abdominal fat is associated with a dramatic increase in the risk of early death in generally healthy older adults who are not obese. 

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Belly_Fat

(Image: AARP / AHMET YARALI / GETTY IMAGES)

Metabolism

Model: 16-month-old male C57BL/6 mice 
Dosage (oral): 5 mg/kg of dasatinib and 50 mg/kg of quercetin biweekly for 4 months

Senolytic Treatment Rejuvenates Intestines 

The senolytic — compound that eliminates aged cells — combo dasatinib and quercetin (D+Q) promotes small intestine regeneration in aged mice. 


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A fluorescent image of the intestinal wall of an aged mouse. Dead cells (red) are depicted among normal (blue) cells. 

Model: Aged (20-month-old) male C57BL/6J mice fed a high-fat diet to induce obesity
Dosage (oral): 30 mg/kg of GABA

Supplementing with GABA (γ-aminobutyric acid) — the brain’s inhibitory neurotransmitter — prevents muscle and strength loss, fat gain, and insulin resistance in aged mice fed excess calories.  

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A top view of DEXA (dual x-ray absorptiometry) scans from young (first and second panel) and old (third and fourth panel) mice showing fat mass (red) and muscle mass (green) ratios. Mice treated with GABA (first and third panel) have less fat and more muscle. 

Discover how a Korean study highlights the remarkable potential of the natural molecule GABA in preventing age-related obesity and muscle loss. Explore the groundbreaking findings at NAD.com.

Natural Molecule GABA Prevents Age-Related Obesity and Muscle Loss: Korean Study Reveals | NAD

Model: Adults over age 40
Dosage: An average of 25 mg of dietary niacin per day and up to 238 mg per day

New Study Links NAD⁺ Precursor Niacin with Muscle Strength and Insulin Sensitivity

Researchers show a link between higher dietary niacin and improved muscle strength, lower body fat, and enhanced insulin sensitivity in adults over age 40.

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NIACIN

(A muscular man in his 40s alongside a niacin molecule)

Discover groundbreaking findings from the latest study on niacin, a precursor to NAD, revealing its remarkable benefits for boosting muscle strength and improving insulin sensitivity in adults over 40. Explore the full story at NAD.com.

Model: C57BL/6 mice (18-20 months old)
Dosage: 468.1 mg/kg per day (equivalent of 2 g per day for a 60 kg adult) for six weeks

Recent Study Shows Turmeric-Derived Curcumin Reduces Weight Gain

Researchers show that dietary curcumin prevents inflammatory gene activity, improves metabolism, and suppresses weight gain in aged mice.

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Turmeric

Curcumin suppresses inflammation to improve metabolism and prevent weight gain in aged mice. Discover the findings of a recent study highlighting the anti-inflammatory properties of curcumin, a compound derived from turmeric, in preventing weight gain. Explore the potential of curcumin as a natural remedy to suppress inflammation and support weight management. Read more on NAD.

Recent Study Shows Turmeric-Derived Curcumin Suppresses Inflammation to Prevent Weight Gain - NAD

Model: NAD+-deficient mice
Dosage (oral): 400 mg/kg of nicotinamide riboside (NR)

Chinese scientists enhance the fertility of middle-aged mice with nicotinamide riboside (NR) by addressing the cellular metabolic deficits associated with aging ovaries.

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4-cell embryos from the ovaries of mice given NR. 

 Explore the findings of a new study revealing the potential of NR (nicotinamide riboside) in enhancing female reproductive lifespan and promoting fertility in middle age. Discover the impact of NAD (nicotinamide adenine dinucleotide) supplementation on reproductive health and the promising advancements in fertility research. Read more on NAD.

New Study Shows NR Enhances Female Reproductive Lifespan and Promotes Fertility in Middle Age - NAD

Participants: Healthy adults (18 to 47 years old)
Dosage: 1 g of an NAD+ precursor, 12.35 g of L-serine, 3.73 g of L-carnitine tartrate, and 2.55 g of N-acetyl cysteine

Of five different NAD+ precursors, NMN and NR similarly reduce blood fat levels and boost NAD+ levels when combined with an antioxidant and fat-burning blend, called the combined metabolic activator (CMA), in healthy adults.  


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Discover the latest international study revealing the metabolic health effects of NMN and NR formulations. Explore the similarities and benefits of these NAD+ precursors for improving overall metabolic health.

NMN and NR Formulations Exert Similar Metabolic Health Effects: Latest International Study

Iranian scientists find that liver cell death and fat accumulation are synergistically diminished by metformin and resveratrol in human cells by activating the longevity-mediating SIRT1 enzyme. 


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Model: Human chronic kidney disease patients with an average age of 60
Dosage: 1,000 mg per day of NR by pill for six weeks; 1,200 mg per day of CoQ10 by pill for six weeks

NR and CoQ10 Improve Kidney Function: Latest Study

A kidney disease patient study reveals nicotinamide riboside (NR) increases intermediate molecules of metabolism, and NR and coenzyme Q10 (CoQ10) both reduce harmful fats.

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DAVIS

(University of California, Davis | theaggie.org)

NR significantly increases mitochondrial metabolism molecular intermediates, while both NR and CoQ10 improve lipid metabolism profiles, both suggesting metabolic improvements.

Clinical Trials

Model: C57BL/6J mice (male, 8 months old); APP/PS1 double transgenic (APPswe/PSEN1dE9) mice with five familial Alzheimer’s diseases (5 FAD); and littermate wild-type C57BL/6J mice (male, 8 months old) 
Dosage: neoagarotetraose (NAT) 1000 mg/kg*bw/d via drinking water

Researchers show that the dietary prebiotic neagarotetraose (NAT) - a compound that alters the microbiome - prolongs lifespan and mitigates age-related brain damage in mice by regulating the gut.

Mitochondrial NAD⁺ Transporter Identified

New Research Study Claims Belly Fat Increases Risk of Early Death by Whopping 365%

Leveraging Nutrient Uptake to Slow Aging: Research Reveals Senolytic Treatment Rejuvenates Intestines

New Korean Study Shows GABA Prevents Age-Related Obesity and Muscle Loss

New Study Links NAD⁺ Precursor Niacin with Muscle Strength and Insulin Sensitivity

Recent Study Shows Turmeric-Derived Curcumin Suppresses Inflammation and Reduces Weight Gain

New Study Shows NR Enhances Female Reproductive Lifespan and Promotes Fertility in Middle-Age

NMN and NR Formulations Exert Similar Metabolic Health Effects: Latest International Study

Study Reveals Synergistic Power of Metformin and Resveratrol in Combating Liver Deterioration

NR and CoQ10 Improve Kidney Function: Latest Study

Scientists Successfully Increase Lifespan and Delay Brain Aging with New Prebiotic