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Diabetes & Obesity

Weight Loss Drug Protects Against Diabetic Sarcopenia: New Study Finds

Researchers show that liraglutide protects muscle from diabetes-induced atrophy by reversing cellular aging and activating the YAP/TAZ signaling pathway.

By Dylan G. Arrazati

Key Points: 

  • Liraglutide preserves muscle mass and fiber composition in diabetic rats by reversing atrophy and restoring fast-twitch fibers, the muscle cells responsible for rapid and powerful movements.
  • The drug’s protective effects are mediated through the activation of cell growth signaling pathway (YAP/TAZ) and suppression of aging-related proteins P53 and P21.
  • Liraglutide reduces markers of senescence – a harmful state of cell cycle arrest that accelerates aging

Sarcopenia—the gradual loss of muscle mass and function—is often thought of as a normal part of aging. But for people with type 2 diabetes, this process tends to happen earlier, faster, and more severely. In recent years, researchers have begun to recognize diabetic sarcopenia as a distinct and damaging complication of the disease, one that worsens frailty, lowers quality of life, and increases mortality.

Now, a new study published in the Journal of Diabetes and Its Complications offers fresh insight into how one existing diabetes drug, liraglutide, could help fight back. While already approved for lowering blood sugar and aiding weight loss, liraglutide appears to protect muscle from atrophy by slowing cellular aging and activating a crucial cell growth pathway known as YAP/TAZ.

Liraglutide Reverses Muscle Loss in Diabetic Rats

To model diabetic sarcopenia, researchers fed rats a high-fat, high-sugar diet and gave them a low dose of streptozotocin, a chemical that damages insulin-producing cells. The result was a reliable animal model of type 2 diabetes. Compared to healthy rats, the diabetic animals had smaller, weaker gastrocnemius muscles (a major calf muscle), with signs of tissue damage, disorganized fibers, and a shift in muscle composition from fast-twitch to slow-twitch fibers—hallmarks of muscle atrophy and decline.

However, when the diabetic rats were treated with liraglutide for eight weeks, their muscles partially recovered. The treated group showed increased muscle size and better structure, with more fast-twitch fibers—important for strength and quick movement. Together, the findings suggest that liraglutide helps reverse diabetes-induced muscle atrophy and restores key features of healthy muscle function.

(Xu et al., 2025 | Journal of Diabetes and Its Complications) Liraglutide (Li) Reverses Muscle Loss in Diabetic Rats. (D) The gastrocnemius muscles of diabetic rats treated with Li weigh more than untreated diabetic rats (DM). (E) These muscles are also longer in diabetic rats treated with Li. (F) Liraglutide treatment increased muscle fiber size in diabetic rats, partially reversing the shrinkage seen in untreated diabetic muscle. (G) Diabetic rats treated with Li have more fast-twitch fibers than untreated diabetic rats. 

Muscle Aging Is Accelerated by High Glucose, But Liraglutide Slows It Down

To explore the mechanism behind this protective effect, the researchers turned to a widely used muscle cell line called C2C12 myoblasts, which can be grown in a dish and transformed into mature muscle cells (myotubes). When exposed to high glucose levels—mimicking diabetic conditions—these cells began to shrink, fall apart, and show classic signs of aging, including accumulation of the enzyme β-galactosidase, which marks senescence – a harmful state of cell cycle arrest that accelerates aging.

However, when liraglutide was added to the mix, the muscle cells fared much better. They stayed longer, larger, and less senescent, suggesting that liraglutide directly protects muscle cells from the harmful effects of excess glucose.

YAP/TAZ: A Cellular Switch That Keeps Muscle Young

The study’s investigators turned their attention to the YAP/TAZ signaling pathway because it is a well-known regulator of cell growth, regeneration, and tissue repair—all of which are impaired in diabetic muscle atrophy. Prior research has shown that disruptions in this pathway contribute to aging and degeneration in multiple tissues, making it a compelling candidate for further exploration.

In their diabetic muscle cell model, the researchers observed that high-glucose conditions suppressed YAP/TAZ activity. This was accompanied by increased expression of aging-associated proteins P53 and P21. Remarkably, treatment with liraglutide reversed these effects: it reactivated YAP/TAZ signaling and reduced P53 and P21 expression, shifting the cells toward a more regenerative, youthful state. 

To confirm whether this pathway was essential to liraglutide’s effects, the researchers introduced Verteporfin, a compound known to block YAP activity. When YAP/TAZ signaling was shut down, liraglutide no longer reduced aging markers or improved cell growth, indicating that its protective effects on muscle cells depend on this specific pathway. 

Broader Implications for Muscle Aging and Diabetes

Although this study focused on muscle loss in type 2 diabetes, it speaks to a wider connection between metabolic dysfunction and accelerated aging. Elevated glucose levels have long been known to promote cellular aging in the brain, kidneys, and blood vessels; this research extends that pattern to skeletal muscle and highlights YAP/TAZ as a central pathway involved in protection.

Previous studies have found that YAP/TAZ signaling declines with age and under metabolic stress, while physical activity appears to restore it—suggesting that it may be a shared target across lifestyle and pharmaceutical interventions. Since liraglutide is already approved for clinical use and has a favorable safety profile, these findings open the door to exploring its potential as a treatment for muscle loss beyond diabetes.

Model & Dosage:

Model: Type 2 diabetic rats induced by high-fat diet and low-dose streptozotocin (STZ)
Dosage: 0.2 mg/kg liraglutide administered daily for 8 weeks

Source

Qian Xu, Xuan Qiu, Hailing Di, Zhongkang Li, Zanchao Liu, Kuanzhi Liu, Liraglutide improves senescence and ameliorating diabetic sarcopenia via the YAP-TAZ pathway, Journal of Diabetes and its Complications, Volume 39, Issue 3, 2025, 108975, ISSN 1056-8727, https://doi.org/10.1016/j.jdiacomp.2025.108975.

References

Limyati Y, Sanjaya A, Lucretia T, Gunadi JW, Biben V, Jasaputra DK, Lesmana R. Potential Role of Exercise in Regulating YAP and TAZ During Cardiomyocytes Aging. Curr Cardiol Rev. 2022;18(5):24-33. doi: 10.2174/1573403X18666220404152924. PMID: 35379136; PMCID: PMC9896415.

 

Guo J, Zheng HJ, Zhang W, Lou W, Xia C, Han XT, Huang WJ, Zhang F, Wang Y, Liu WJ. Accelerated Kidney Aging in Diabetes Mellitus. Oxid Med Cell Longev. 2020 Jul 27;2020:1234059. doi: 10.1155/2020/1234059. PMID: 32774664; PMCID: PMC7407029.

 

Rask-Madsen C, King GL. Vascular complications of diabetes: mechanisms of injury and protective factors. Cell Metab. 2013 Jan 8;17(1):20-33. doi: 10.1016/j.cmet.2012.11.012. PMID: 23312281; PMCID: PMC3546345.

 

Kim JY, Quan T. Emerging Perspectives of YAP/TAZ in Human Skin Epidermal and Dermal Aging. Ann Dermatol. 2024 Jun;36(3):135-144. doi: 10.5021/ad.23.156. PMID: 38816974; PMCID: PMC11148314.

 

https://hms.harvard.edu/news-events/publications-archive/brain/sugar-brain

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