Model: 16-month-old female C57BL/6 mice 
Dosage: 60 mg/kg/day of ABT-263 dissolved in drinking water for 7 days on, 7 days off, and 7 days on again

A compound that removes age-promoting cells accelerates ovarian aging in aged mice, suggesting it promotes infertility. 

Others

Model: 27-month-old male C57BL/6N mice 
Intermittent Dosing (oral): 1 week of 100 mg/kg/day of fisetin, followed by 2 weeks of no intervention, followed by 1 week of 100 mg/kg/day of fisetin

Fisetin supplementation counteracts artery aging in old mice by preserving artery elasticity and function via senolytic action — removal of senescent (dysfunctional) cells.  


Lead investigator Sophia Mahoney | University of Colorado Boulder

Cardiovascular

Scientists maintain the function of fat-derived stem cells by boosting NAD+ with nicotinamide riboside (NR), which could combat age-related liver and muscle ailments.



A woman next to a nicotinamide riboside (NR) molecule. 

Model: Male Titan mice
Dose (oral): 50 mg/kg of Navitoclax for 5 days followed by 16 day break repeated 5 times

German scientists cut the weight of obese mice and prolong their lifespan by 16.7% by reducing senescent age-driving cells with the senolytic Navitoclax.  



Most of the study’s investigators (from left to right): Annika Muller-Eigner, Dr. Shahaf Peleg, Shari Gottschalk, Benedikt Gille, and Verena Hofer-Pretz | Shahaf Peleg Lab 

Explore the findings of a groundbreaking German study showcasing how Senolytic therapy leads to weight loss and increased lifespan in obese mice. Learn about the promising implications for obesity management and longevity in this exclusive report from NAD.com.

German Study Demonstrates Senolytic Therapy Helps Obese Mice Lose Weight and Live Longer | NAD

Diabetes &amp; Obesity

Model: Male 6-month-old C57BL/6J mice
Dosage (oral): 5 mg/kg dasatinib plus 50 mg/kg quercetin

The senolytic combo dasatinib plus quercetin (D + Q) improves memory and motivation, reduces brain inflammation, and mitigates neurodegeneration in a mouse model for traumatic brain injury. 

Principal Investigator, Dr. Darrell Brann | Augusta University

Discover groundbreaking findings from the latest study at NAD.com, highlighting the remarkable effects of senolytic therapy in safeguarding the brain from injury while preserving memory. Explore how senolytic treatment offers promising avenues for neuroprotection

Search Result: ABT-263

Who Should Not Take Anti-Aging Senolytic Supplements?

Senolytic Compound Fisetin Preserves Artery Wall Elasticity to Combat Cardiovascular Disease

When More Fat is Good: Study Shows NAD⁺ Precursor NR Rejuvenates Fat Stem Cells

German Study Demonstrates Senolytic Therapy Helps Obese Mice Lose Weight and Live Longer

Latest Study Shows Senolytic Therapy Protects the Brain from Injury and Preserves Memory