Model: 24-month-old male and female C57BL/6J mice
Dosage: 3 mg/kg/day, delivered continuously over 8 weeks

Diabetes Drug Elamipretide Reverses Muscle and Heart Aging: New Study Reveals

Scientists show that elamipretide restores muscle and heart function in aging mice but doesn’t affect epigenetic or transcriptomic age.


Cardiovascular

Multi-Nation Expert Panel Agrees On Biomarkers of Aging

For the first time, a multi-nation panel of aging experts reached a consensus to designate markers of aging, which could make aging intervention testing easier.

(An aged individual holding pills and supplements meant to work against aging | UCLA)

Aging &amp; Longevity

Participants: Physically active and healthy older adults 
Dosage: 1 gram of omega-3s (330 mg EPA plus 660 mg DHA) per day, 2,000 IU of vitamin D per day, and 30 minutes of strength training exercises three times per week

While omega-3 supplementation slows biological aging, adding vitamin D and exercise further slows biological aging.

The “father of aging clocks” and senior study author Steve Horvath, PhD, of Harvard University (Image: quantamagazine.org). 

Model: 40 aged patients with COPD with an average age of 71.9 
Dosage: One gram of NR taken twice daily for a total of two grams per day for six weeks

Fresh Insights: NR’s Effects on Inflammation in Age-Related Lung Disease

Taking nicotinamide riboside (NR) is tied to a 52.6% reduction of an inflammatory protein in the sputum—mucus coughed up from the respiratory tract—of patients with chronic obstructive pulmonary disease (COPD).

(Principal investigator Dr. Morten Scheibye-Knudsen, Associate Professor from the University of Copenhagen | Videnskab DK)

Model: Twenty-five-month-old female Sprague-Dawley rats
Dosage: 1 mL of blood plasma from two-month-old rats intraperitoneally injected every other week until death
Model: C57BL/6J male mice
Dosage: 0.055 mg/mL of ergothioneine administered orally in water from seven weeks of age until death

Canadian Longevity Organization Spotlights Key Research on Latest Anti-Aging Treatments

The Canadian Longevity Association — a non-profit organization dedicated to accelerating longevity research — highlights research on rodent lifespan extension with young plasma and the mushroom-derived compound ergothioneine.

(Canadian Longevity Association | Facebook)

The Canadian Longevity Association presents new findings showing that injecting young plasma into older individuals and mushroom-derived ergothioneine extend lifespan in rodents.

Search Result: DNA methylation

Diabetes Drug Elamipretide Reverses Muscle and Heart Aging: New Study Reveals

Expert Panel Agrees On Biomarkers of Aging for Testing Therapeutics

Harvard Study Reveals that Omega-3s, Vitamin D, and Exercise Additively Slow Biological Aging

Fresh Insights: NR’s Effects on Inflammation in Age-Related Lung Disease

Canadian Longevity Organization Spotlights Key Research on Young Plasma and Mushroom-Based Anti-Aging Treatments