Will Interventions that Delay Aging in Animals Work for Humans?

Researchers have shown that using certain agents targeting hallmarks of aging (like inflammation) can extend lifespan in mice, yet human trials are just beginning to uncover whether they work in humans.

(Aged individuals may benefit from aging interventions that work in animal models | NAD.com)

Aging &amp; Longevity

Model: C57BL/6J mice and Abca1/g1-m/-m mice of both sexes and bone marrow-derived macrophages from C57BL/6J and Abca1/g1-m/-m mice
Dosage: 300 mg/kg of NMN by daily intraperitoneal injection for two weeks, 5 mg/kg of dasatinib and 50 mg/kg of quercetin by oral gavage for five consecutive days every two weeks for three months, and a 500 μM concentration of NMN for bone marrow-derived macrophages in laboratory dishes

Revitalizing Immune Cells & Eye Function: NMN Study Unveils Remarkable Findings

A new study suggests that NMN reverses an age-associated dysfunctional cellular state — senescence — in immune cells and restores eye function in an age-related eye disease mouse model.

(An anatomical view of an eye with age-related macular degeneration | NAD.com)

NMN reverses an age-related dysfunctional state in immune cells — senescence — and improves eye function in an age-related eye disease mouse model.

Bezos and Zuckerberg Invest Millions to Live Longer While Musk Refuses

Amazon founder Jeff Bezos is investing in the aging research company Unity Biotechnology, while Facebook pioneer Mark Zuckerberg annually awards $3 million to aging scientists, yet Elon Musk caustically criticizes these endeavors.

(The world’s wealthiest man and founder of SpaceX, Elon Musk | SFGate)

Billionaires Jeff Bezos and Mark Zuckerberg are investing full-force into anti-aging research; however, Elon Musk rebukes these contributions, saying extending lifespan will cause society to stagnate.

Based on human evidence, Harvard and MIT scientists determine the most promising anti-aging interventions, including NAD+ precursors, spermidine, and senolytics. 


MIT’s Leonard Guarente, Ph.D. (image: amacad.org), Harvard’s David Sinclair, Ph.D. (image: buckinstitute.org), and University of Paris Descartes’ Guido Kromer, Ph.D., M.D. (image: createcures.org). 

David Sinclair and fellow top aging biology researchers review clinical trials pertaining to the eight anti-aging compounds. 

High blood markers related to senescent “aged” cells are associated with an increased risk of mortality in older adults. 

Senior Investigator Dr. Nathan K. LeBrasseur (photo: Jerry Holt) | StarTribune 

Study finds senescence biomarkers in blood predict mortality risk more accurately than age, sex, or race, highlighting potential aging therapies.

Search Result: Dasatinib

Will Interventions that Delay Aging in Animals Work for Humans?

Revitalizing Immune Cells & Eye Function: NMN Study Unveils Remarkable Findings

Bezos and Zuckerberg Invest Millions to Live Longer While Musk Refuses

David Sinclair and Colleagues Summarize 8 Anti-Aging Medicines Applicable to Humans

Mayo Clinic Study Strongly Associates Senescent Cells with Shortened Lifespan