Model: Male C57BL/6 mice 
Dosage: 10 mg/kg of glyburide via intragastric injections or 500 mg/kg of NMN by oral water supply daily starting at 12 months of age until death

Common Diabetes Medication Extends Life, Suggests New Study

Researchers show that glyburide, an anti-diabetes drug, extends lifespan and reduces frailty in naturally aged mice.

(The chemical structure of glyburide, a diabetes medication | PubChem)

Aging &amp; Longevity

Participants: Middle-aged adults carrying two copies of the APOE4 gene 
Dosage: 1 mg/kg/day of rapamycin for 4 weeks

The prescription drug rapamycin a.k.a. sirolimus, an FDA-approved mTOR inhibitor, increases the brain volume of cognitively normal individuals at risk for developing Alzheimer’s disease. 


One of the study’s investigators, Talissa Altes, M.D. (Image: Missouri.edu).

Brain &amp; Neurons

Cumulative Research Suggests Coffee Prolongs Life by 1.8 Years

Worldwide, people consume about 2 billion cups of coffee a day, and a new review associates drinking this caffeinated beverage regularly with an average of 1.8 years added to lifespan.

Researchers have identified government-approved drugs that are associated with a lower risk of mortality.  

Model: 24-month-old female Sprague Dawley rats
Dosage: Undisclosed doses of pig-derived exosomes were injected into the rats every-other-day for eight days starting at day 1 and recommencing at days 68, 181, 280, and 377

Nano-Sized Vesicle Infusions Break Rat Lifespan Record

Nano-sized vesicles called exosomes derived from pig blood plasma significantly extended rat lifespan and broke the record for the longest-living rat.

(An image of Sima, the longest-recorded living rat, at 47 months of age | The Guardian)

Search Result: Lifespan Extension

Common Diabetes Medication Extends Life, Suggests New Study

Neurodegeneration Reversed with mTOR Inhibitor Drug in New Alzheimer’s Study

Cumulative Research Suggests Coffee Prolongs Life by 1.8 Years

Approved Drugs that Increase the Chances of Living a Longer Life

Nano-Sized Vesicle Infusions Break Rat Lifespan Record