The longevity gene klotho prolongs the lifespan of mice while preventing muscle, bone, and brain aging. 

Miguel Chillón, PhD, and Laura Rodriguez-Estevez, researchers from Universitat Autònoma de Barcelona in Spain, who conducted the study (image: uab.cat) 

Aging &amp; Longevity

Model: 10-month-old and 22-month-old naturally aged mice / Rats with Partial Discectomy (PDE)-induced Temporomandibular Joint Osteoarthritis (TMJOA).
Dosage: 0.25% αKG and  0.75% αKG
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Longevity Compound Thwarts Age-Related Joint Degeneration

Researchers found that alpha-ketoglutarate (αKG) can treat osteoarthritis by preserving cartilage and reducing joint inflammation. 

Skin &amp; Muscle

A new model of ChatGPT called ChatGPT4b may expedite Retro Biosciences’ pursuit of increasing human lifespan by 10 years. 


Retro Biosciences CEO Joe Betts-Lacroix (Image: retro.bio) and OpenAI CEO Sam Altman. 

Aside from diet and exercise, senolytics — compounds that remove age-promoting cells — may rejuvenate the immune system and reduce the risk of neurodegeneration and dementia. 

Brain &amp; Neurons

Model: 5xFAD mice
Dosage: 5-µL sprayed into each nostril at concentrations of 30 × 109/100 µL once weekly for two weeks

Exploring a Nasal Spray that Might Delay Alzheimer’s Progression by Years

Researchers use nano-sized vesicles derived from neural stem cells to preserve cognition as well as reduce brain inflammation and plaque buildup in an Alzheimer’s mouse model.

(An aged woman using an intranasal spray to avert Alzheimer's disease progression | NAD.com)

Search Result: Microglia

One-Time Anti-Aging Gene Therapy Treatment Prolongs Life by 20%, New Study Shows

Longevity Compound Thwarts Age-Related Joint Degeneration

ChatGPT and Retro Biosciences: The Future of AI-Backed Age-Reversal Technology?

Scientists Reveal How to Slow Brain Aging with Senolytics

Exploring a Nasal Spray that Might Delay Alzheimer’s Progression by Years