The longevity gene klotho prolongs the lifespan of mice while preventing muscle, bone, and brain aging. 

Miguel Chillón, PhD, and Laura Rodriguez-Estevez, researchers from Universitat Autònoma de Barcelona in Spain, who conducted the study (image: uab.cat) 

Aging &amp; Longevity

Model: 9-month-old male rats 
Dosage: 20 mg/kg of ergothioneine for three weeks

Ergothioneine — a naturally occurring compound found in mushrooms — increases the muscle size of middle-aged rats while extending the lifespan of worms. 


First author of the study, Dunja Petrovic (Image: isas.de)

Skin &amp; Muscle

Biotech Startup Aims to Harness New NAD+-Related Drug Against Aging

The longevity biotech company, MetaShape, has a new compound designed to restore cellular nicotinamide adenine dinucleotide (NAD+) and offset elevated cholesterol, cognitive decline, and neurodegeneration.

 Peptide therapies, stem cell treatments, and NAD+ supplementation are being studied for their potential to thwart age-related decline. 

Model: Male Monkeys 
Dosage: 20 mg/kg/day of metformin

Supplementation of metformin — a first-line treatment for type 2 diabetes and the second-most prescribed medication in the U.S. — improves the learning and memory of older monkeys. 

Search Result: Muscle Regeneration

One-Time Anti-Aging Gene Therapy Treatment Prolongs Life by 20%, New Study Shows

Ergothioneine Boosts NAD+, Mitigates Muscle Aging, and Prolongs Life, New Study Shows

Biotech Startup Aims to Harness New NAD+-Related Drug Against Aging

Can We Slow Down Aging? Inside the Cutting-Edge Science of Peptides, Stem Cells, and NAD+

Metformin Slows Brain Aging in Older Monkeys, New Research Shows