Columbia University scientists find that senolytics — compounds that remove age-promoting cells — restore hair follicle regeneration in a human cell/mouse model. 

Skin &amp; Muscle

Model: 16-month-old female C57BL/6 mice 
Dosage: 60 mg/kg/day of ABT-263 dissolved in drinking water for 7 days on, 7 days off, and 7 days on again

A senolytic compound and anti-cancer drug called ABT-263 accelerates ovarian aging in aged mice, suggesting it promotes infertility. 

Others

Model: Male Titan mice
Dose (oral): 50 mg/kg of Navitoclax for 5 days followed by 16 day break repeated 5 times

German scientists cut the weight of obese mice and prolong their lifespan by 16.7% by reducing senescent age-driving cells with the senolytic Navitoclax.  



Most of the study’s investigators (from left to right): Annika Muller-Eigner, Dr. Shahaf Peleg, Shari Gottschalk, Benedikt Gille, and Verena Hofer-Pretz | Shahaf Peleg Lab 

Explore the findings of a groundbreaking German study showcasing how Senolytic therapy leads to weight loss and increased lifespan in obese mice. Learn about the promising implications for obesity management and longevity in this exclusive report from NAD.com.

German Study Demonstrates Senolytic Therapy Helps Obese Mice Lose Weight and Live Longer | NAD

Diabetes &amp; Obesity

Model: Human skin from 78 to 91-year-old men transplanted into mice
Dosage: 50 mg/kg/day intraperitoneal injections of Navitoclax (ABT-263)

Senolytic Agent Rejuvenates Aged Human Skin: Japanese Study

A new study shows that the senolytic Navitoclax can counter the buildup of inflammation-inducing senescent (aged) cells to improve skin structural resilience in mice with human skin grafts.

Navitoclax reduces the abundance of skin senescent cells with age, diminishes the inflammatory molecules from senescent cells, and improves the skin’s structural resilience.

Model: male C57BL/6 mice
Dosage (oral): 5 mg/kg dasatinib plus quercetin or 50 mg/kg ABT263

Old Blood Induces Aging in Young Mice by Spreading Senescence

By transferring blood from old to young mice, Buck scientists show that young mice exhibit increased levels of senescent (aged) cells and of age-related muscle, liver, and kidney disease markers. 


Corresponding author, Judith Campisi, Ph.D. | Buck Institute for Research on Aging 

Search Result: Navitoclax

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German Study Demonstrates Senolytic Therapy Helps Obese Mice Lose Weight and Live Longer

Senolytic Agent Rejuvenates Aged Human Skin: Japanese Study

Buck Institute Researchers Find that Old Blood Induces Aging in Young Mice by Spreading Senescence