Model: 16-month-old female C57BL/6 mice 
Dosage: 60 mg/kg/day of ABT-263 dissolved in drinking water for 7 days on, 7 days off, and 7 days on again

A compound that removes age-promoting cells accelerates ovarian aging in aged mice, suggesting it promotes infertility. 

Others

Model: Male Titan mice
Dose (oral): 50 mg/kg of Navitoclax for 5 days followed by 16 day break repeated 5 times

German scientists cut the weight of obese mice and prolong their lifespan by 16.7% by reducing senescent age-driving cells with the senolytic Navitoclax.  



Most of the study’s investigators (from left to right): Annika Muller-Eigner, Dr. Shahaf Peleg, Shari Gottschalk, Benedikt Gille, and Verena Hofer-Pretz | Shahaf Peleg Lab 

Explore the findings of a groundbreaking German study showcasing how Senolytic therapy leads to weight loss and increased lifespan in obese mice. Learn about the promising implications for obesity management and longevity in this exclusive report from NAD.com.

German Study Demonstrates Senolytic Therapy Helps Obese Mice Lose Weight and Live Longer | NAD

Diabetes &amp; Obesity

Model: Human skin from 78 to 91-year-old men transplanted into mice
Dosage: 50 mg/kg/day intraperitoneal injections of Navitoclax (ABT-263)

Senolytic Agent Rejuvenates Aged Human Skin: Japanese Study

A new study shows that the senolytic Navitoclax can counter the buildup of inflammation-inducing senescent (aged) cells to improve skin structural resilience in mice with human skin grafts.

Navitoclax reduces the abundance of skin senescent cells with age, diminishes the inflammatory molecules from senescent cells, and improves the skin’s structural resilience.

Skin &amp; Muscle

Model: male C57BL/6 mice
Dosage (oral): 5 mg/kg dasatinib plus quercetin or 50 mg/kg ABT263

Old Blood Induces Aging in Young Mice by Spreading Senescence

By transferring blood from old to young mice, Buck scientists show that young mice exhibit increased levels of senescent (aged) cells and of age-related muscle, liver, and kidney disease markers. 


Corresponding author, Judith Campisi, Ph.D. | Buck Institute for Research on Aging 

Aging &amp; Longevity

Canadian scientists find that destroying "zombie-like" senescent neural stem cells in the hippocampus with the senolytic ABT-263 restores neurogenesis and improves spatial memory in middle-aged mice. 


By deleting zombie cells from the brain's memory pathways, Canadian scientists improve learning and memory in mice.

Search Result: Navitoclax

Who Should Not Take Anti-Aging Senolytic Supplements?

German Study Demonstrates Senolytic Therapy Helps Obese Mice Lose Weight and Live Longer

Senolytic Agent Rejuvenates Aged Human Skin: Japanese Study

Buck Institute Researchers Find that Old Blood Induces Aging in Young Mice by Spreading Senescence

Senolytic Improves Age-Related Memory Loss