The cutoff for vitamin B12 deficiency is too low, according to new findings showing that “normal” B12 levels are associated with neurological deficits in older adults. 


Senior investigator, Ari Green, MD (image: ucsfhealth.org). 

Brain &amp; Neurons

Participants: Physically active and healthy older adults 
Dosage: 1 gram of omega-3s (330 mg EPA plus 660 mg DHA) per day, 2,000 IU of vitamin D per day, and 30 minutes of strength training exercises three times per week

While omega-3 supplementation slows biological aging, adding vitamin D and exercise further slows biological aging.

The “father of aging clocks” and senior study author Steve Horvath, PhD, of Harvard University (Image: quantamagazine.org). 

Aging &amp; Longevity

Participants: Healthy older adults 
Dosage: 4 × 5 g/day of creatine monohydrate for 5 days, followed by 1 × 5 g/day for 23 days

Creatine improves vascular health while lowering blood glucose and triglyceride levels in older adults.

Cardiovascular

Model: 9-month-old male rats 
Dosage: 20 mg/kg of ergothioneine for three weeks

Ergothioneine — a naturally occurring compound found in mushrooms — increases the muscle size of middle-aged rats while extending the lifespan of worms. 


First author of the study, Dunja Petrovic (Image: isas.de)

Skin &amp; Muscle

Model: Male Sprague Dawley rats
Dosage: 1.5 mg/kg body or rapamycin injected 3 times a week for 4 weeks

The longevity-associated drug rapamycin diminishes muscle size and strength in young rats when compared to untreated but calorically restricted young rats. 

Search Result: Supplement

You May Not Be Getting Enough Vitamin B12, Latest Study Finds Recommended Dose Is Wrong

Harvard Study Reveals that Omega-3s, Vitamin D, and Exercise Additively Slow Biological Aging

New Pilot Study Reveals How Creatine Affects Heart Health

Ergothioneine Boosts NAD+, Mitigates Muscle Aging, and Prolongs Life, New Study Shows

Can You Build Muscle on Rapamycin? Not If You Are Too Young, Says New Research