Model: 16-month-old female C57BL/6 mice 
Dosage: 60 mg/kg/day of ABT-263 dissolved in drinking water for 7 days on, 7 days off, and 7 days on again

A compound that removes age-promoting cells accelerates ovarian aging in aged mice, suggesting it promotes infertility. 

Others

Based on human evidence, Harvard and MIT scientists determine the most promising anti-aging interventions, including NAD+ precursors, spermidine, and senolytics. 


MIT’s Leonard Guarente, Ph.D. (image: amacad.org), Harvard’s David Sinclair, Ph.D. (image: buckinstitute.org), and University of Paris Descartes’ Guido Kromer, Ph.D., M.D. (image: createcures.org). 

David Sinclair and fellow top aging biology researchers review clinical trials pertaining to the eight anti-aging compounds. 

Aging &amp; Longevity

Model: NAD+-deficient mice
Dosage (oral): 400 mg/kg of nicotinamide riboside (NR)

Chinese scientists enhance the fertility of middle-aged mice with nicotinamide riboside (NR) by addressing the cellular metabolic deficits associated with aging ovaries.

4-cell embryos from the ovaries of mice given NR. 

 Explore the findings of a new study revealing the potential of NR (nicotinamide riboside) in enhancing female reproductive lifespan and promoting fertility in middle age. Discover the impact of NAD (nicotinamide adenine dinucleotide) supplementation on reproductive health and the promising advancements in fertility research. Read more on NAD.

New Study Shows NR Enhances Female Reproductive Lifespan and Promotes Fertility in Middle Age - NAD

Metabolism

Model: Young (3 months) and old (20 months), male Wistar rats
Dosage: resveratrol 20 mg/kg/day, intraperitoneal (IP) injection for 28 days

Study Reaffirms Resveratrol’s Potent Brain-Boosting Properties

A new study reveals that resveratrol supplementation thwarts age-related memory impairment and motor dysfunction in naturally aging rats. 

Model: Female C57BL/6J mice 
Dosage: 10 mg/kg by oral gavage twice weekly

Resveratrol Derivative Delays Ovarian Aging and Egg Cell Decline

With a plant-based polyphenol called THSG, scientists delay ovarian aging and egg cell decline by boosting sex hormone activity in mice. 


Jacqueline Whang-Peng, Corresponding Author 

With a plant-based polyphenol called THSG, scientists delay ovarian aging and egg cell decline by boosting sex hormone activity in mice. 

Search Result: infertility

Who Should Not Take Anti-Aging Senolytic Supplements?

David Sinclair and Colleagues Summarize 8 Anti-Aging Medicines Applicable to Humans

New Study Shows NR Enhances Female Reproductive Lifespan and Promotes Fertility in Middle-Age

Study Reaffirms Resveratrol’s Potent Brain-Boosting Properties

New Study Shows Resveratrol Derivative Delays Ovarian Aging and Egg Cell Decline