A molecule known as miR-302b prolongs the life of mice by “waking up” senescent cells — “sleeping” cells that contribute to life-shortening chronic diseases. 

Depiction of microRNA molecules (Image: Artur Plawgo/iStock Photo/MIT.edu). 

Aging &amp; Longevity

With over 246 million data points, obtained from 108 participants, scientists show that we rapidly age around 45 and 60. 

Stanford researchers find that our biological age accelerates during mid-life and retirement age. 

Model: UM-HET3 mice
Dosage: Astaxanthin was fed at 4,000 ppm in the diet beginning after weaning
Meclizine was fed at 800 ppm in the diet beginning after weaning
Administering fisetin started at 20 months old and was fed continuously or a repeated cycle of three days on and 11 days off at a target of 600 ppm in the diet

Over-the-Counter Wonders: New Research Highlights Two Compounds for a Longer Life

A consortium that examines longevity interventions in mice has found that the anti-nausea compound meclizine as well as the antioxidant astaxanthin extend male mouse lifespan.

(A long-lived mouse surrounded by potential lifespan-extending compounds | NAD.com)

A consortium of researchers has identified the anti-seasickness drug meclizine and the antioxidant astaxanthin as two compounds that significantly extend male mouse lifespan.

Model: Young and middle-aged nonobese adults included in the CALERIE study
Dosage: Reducing calorie intake by ~12% over a two-year period

Calorie Restriction in NIA Human Trial: Achieving Weight Loss While Preserving Strength

National Institute on Aging (NIA) researchers show that cutting 12% of calories from the diet over two years results in weight loss, preserved strength, and stimulation of longevity genes.

(Study author and NIA Scientific Director Luigi Ferrucci, MD, PhD | nia.nih.gov)

Cutting ~12% of calories from the diet over two years results in weight loss, preserved strength, and longevity gene stimulation in adults.

Skin &amp; Muscle

Vitamin D reduces human colorectal cancer cell growth by activating the NAD+ dependent enzyme sirtuin-1. 

University of Rey Juan Carlos in Spain (photo: Eduardo Parra / Europa Press). 

Explore groundbreaking research from Spain revealing how Vitamin D activates NAD-dependent molecules to combat cancer. Discover the implications of this study and its potential in cancer treatment at NAD.com.

Search Result: mRNA

New Age-Reversal Therapy Prolongs Life by Targeting Senescent Cells

Epic New Stanford Study Reveals Two Critical Phases of Rapid Aging in Our Lifetime

Over-the-Counter Wonders: New Research Highlights Two Compounds for a Longer Life

Caloric Restriction Preserves Muscle Strength Despite Muscle Loss: National Institute on Aging

Vitamin D Stops Cancer Growth by Activating NAD⁺ and Sirtuin-1: Research from Spain