Older adults with LDL cholesterol levels above 130 mg/dL live longer than older adults with LDL cholesterol levels below 130 mg/dL. 

The participants of the study were from Sardinia, Italy (image: businessinsider.com). 

Metabolism

Model: 10-month-old and 22-month-old naturally aged mice / Rats with Partial Discectomy (PDE)-induced Temporomandibular Joint Osteoarthritis (TMJOA).
Dosage: 0.25% αKG and  0.75% αKG
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Longevity Compound Thwarts Age-Related Joint Degeneration

Researchers found that alpha-ketoglutarate (αKG) can treat osteoarthritis by preserving cartilage and reducing joint inflammation. 

Skin &amp; Muscle

Stop Fast Aging! New Research Suggests Protecting One Organ Helps All

Researchers from University College London unveil data suggesting that accelerated aging in certain organs increases the risk of age-related diseases across other organs.

(University College London | The Independent)

Aging &amp; Longevity

Participants: Middle-aged adults carrying two copies of the APOE4 gene 
Dosage: 1 mg/kg/day of rapamycin for 4 weeks

The prescription drug rapamycin a.k.a. sirolimus, an FDA-approved mTOR inhibitor, increases the brain volume of cognitively normal individuals at risk for developing Alzheimer’s disease. 


One of the study’s investigators, Talissa Altes, M.D. (Image: Missouri.edu).

Brain &amp; Neurons

Model: 9-month-old male rats 
Dosage: 20 mg/kg of ergothioneine for three weeks

Ergothioneine — a naturally occurring compound found in mushrooms — increases the muscle size of middle-aged rats while extending the lifespan of worms. 


First author of the study, Dunja Petrovic (Image: isas.de)

Search Result: middle-age

New Study Shows People with Higher Cholesterol Live Longer than People with Lower Cholesterol

Longevity Compound Thwarts Age-Related Joint Degeneration

Stop Fast Aging! New Research Suggests Protecting One Organ Helps All

Neurodegeneration Reversed with mTOR Inhibitor Drug in New Alzheimer’s Study

Ergothioneine Boosts NAD+, Mitigates Muscle Aging, and Prolongs Life, New Study Shows