Model: 16-month-old female C57BL/6 mice 
Dosage: 60 mg/kg/day of ABT-263 dissolved in drinking water for 7 days on, 7 days off, and 7 days on again

A senolytic compound and anti-cancer drug called ABT-263 accelerates ovarian aging in aged mice, suggesting it promotes infertility. 

Others

An immune system enzyme called CD38 is associated with low NAD+ levels, shortened reproductive lifespan, and fertility problems in female mice.  


Immunity

Model: NAD+-deficient mice
Dosage (oral): 400 mg/kg of nicotinamide riboside (NR)

Chinese scientists enhance the fertility of middle-aged mice with nicotinamide riboside (NR) by addressing the cellular metabolic deficits associated with aging ovaries.

4-cell embryos from the ovaries of mice given NR. 

 Explore the findings of a new study revealing the potential of NR (nicotinamide riboside) in enhancing female reproductive lifespan and promoting fertility in middle age. Discover the impact of NAD (nicotinamide adenine dinucleotide) supplementation on reproductive health and the promising advancements in fertility research. Read more on NAD.

New Study Shows NR Enhances Female Reproductive Lifespan and Promotes Fertility in Middle Age - NAD

Metabolism

Model: Female C57BL/6 mice
Dosage: Fasting every-other-day

Scientists find that intermittent fasting – fasting every other day – increases mouse litter size and raises NAD+ in aged mouse eggs (oocytes).

From left to right: young, aged, and aged + intermittent fasting mouse egg cells stained with a green marker for cell death.

Model: Female C57BL/6J mice 
Dosage: 10 mg/kg by oral gavage twice weekly

Resveratrol Derivative Delays Ovarian Aging and Egg Cell Decline

With a plant-based polyphenol called THSG, scientists delay ovarian aging and egg cell decline by boosting sex hormone activity in mice. 


Jacqueline Whang-Peng, Corresponding Author 

With a plant-based polyphenol called THSG, scientists delay ovarian aging and egg cell decline by boosting sex hormone activity in mice. 

Search Result: oocytes

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New Study Shows NR Enhances Female Reproductive Lifespan and Promotes Fertility in Middle-Age

Study Shows Intermittent Fasting Delays Reproductive Aging and Promotes Fertility

New Study Shows Resveratrol Derivative Delays Ovarian Aging and Egg Cell Decline