NAD+ Precursors: Unlocking the Fountain of Youth by Maximizing NAD+ Levels

Nicotinamide adenine dinucleotide (NAD+) levels decline with age, which has been linked to age-related conditions, yet NAD+-boosting precursors replenish this essential molecule.

Maximizing NAD+ levels with the precursors tryptophan, nicotinic acid, nicotinamide, NMN, or NR can alleviate age-associated diseases like cardiovascular ailments and neurodegenerative conditions.

Aging &amp; Longevity

Model: ICR mice
Dosage: NAD+ 50 mg/kg via intravenous injection one hour after ischemia
                 NBP 30 mg/kg via intraperitoneal injection four hours after ischemia
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Researchers Demonstrate NAD+ Can Help with Stroke Recovery

Mice treated with nicotinamide adenine dinucleotide (NAD+) following oxygen deprivation (ischemia) to their brains due to stroke had decreased brain injury and neurological deficits due to increased sirtuin activity.


College of Pharmaceutical Sciences of Soochow University

Model: Wistar rats fed a high-fat diet and injected with streptozotocin to model diabetes and diabetic nephropathy
Dose (oral): 100 mg/kg honokiol, or 150 mg/kg metformin for 8 weeks

Honokiol — a molecule found in Magnolia plants — and metformin — a diabetes drug — comparably stabilize blood glucose levels, reduce inflammation, and deter kidney damage in a rat model for diabetes. 

Principal Investigator, Dr. Manish Kumar | LinkedIn

A summary of the effects of boosting NAD+ with its precursors on human aging.


Nicotinamide riboside (NR, left) and nicotinamide mononucleotide (NMN, right), the most well-studied NAD+ precursors. 

Reviews

Wild-type mtKeima transgenic mice/ Wild-type C57BL/6J mice
Nicotinamide Riboside: Oral supplementation via drinking water (24 mM) for 10 months

NIA Successfully Halts Age-Related Hearing Loss with NR

National Institute of Aging (NIA) scientists show that NR, a precursor to the life-preserving nicotinamide adenine dinucleotide (NAD+), exerts protective effects against age-related hearing loss in mice.  


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NAD⁺ Precursors: Unlocking the Fountain of Youth by Maximizing NAD+ Levels

Researchers Demonstrate NAD+ Can Help with Stroke Recovery

Honokiol is a Potential Natural Alternative to Metformin for Diabetes and Kidney Health, Suggests Study

NAD⁺ Precursors and Aging

NIA Researchers Show NR Halts Age-Related Hearing Loss