Model: Male Monkeys 
Dosage: 20 mg/kg/day of metformin

Supplementation of metformin — a first-line treatment for type 2 diabetes and the second-most prescribed medication in the U.S. — improves the learning and memory of older monkeys. 

Brain &amp; Neurons

<ul>
<li style="font-weight: 400;" aria-level="1">Cultured human lung fibroblasts with five types of senescence: Etoposide,  P16INK4a over-expression, KRAS, replicative, and UV</li>
<li style="font-weight: 400;" aria-level="1">Irradiated or naturally aged (24 months old) mice were treated with mock- or mNKG2D-CAR T; irradiation-accelerated mouse model of aging, wild-type C57BL/6 mice (8 to 10 weeks old)</li>
<li style="font-weight: 400;" aria-level="1">Three rhesus macaques and two cynomolgus macaques</li>
</ul>

Engineered Immune Cells Can Hunt Down and Eliminate Aging Cells

A study demonstrates that engineered immune cells can serve as potent and selective medicine for cells at the center of aging and age-associated diseases. 


According to a new senate bill, funding is being allocated towards research focused on delaying or reversing aging with a new technology called epigenetic reprogramming — genetically restoring cells to an earlier stage of development. 

Aging &amp; Longevity

<ul>
<li style="font-weight: 400;" aria-level="1">The monkeys used in the study, including eight young ones (4–6 years old, four females and four males) and eight aged ones (18–21 years old, four females and four males), were originally from Southeast Asia.</li>
<li style="font-weight: 400;" aria-level="1">Three groups of male C57BL6/J mice: young-lenti-Luc (2-month-old), aged-lenti-Luc (24-month-old) and aged-lenti-SIRT2 (24-month-old).</li>
<li style="font-weight: 400;" aria-level="1">hiPSC derived CMs</li>
</ul>

New Study Reveals Activating Sirtuins Could Reverse Heart Aging 

Researchers have identified a sirtuin (SIRT2) as a therapeutic target for age-related cardiovascular disease.

Cardiovascular

Model: Young and middle-aged nonobese adults included in the CALERIE study
Dosage: Reducing calorie intake by ~12% over a two-year period

Calorie Restriction in NIA Human Trial: Achieving Weight Loss While Preserving Strength

National Institute on Aging (NIA) researchers show that cutting 12% of calories from the diet over two years results in weight loss, preserved strength, and stimulation of longevity genes.

(Study author and NIA Scientific Director Luigi Ferrucci, MD, PhD | nia.nih.gov)

Cutting ~12% of calories from the diet over two years results in weight loss, preserved strength, and longevity gene stimulation in adults.

Search Result: primates

Metformin Slows Brain Aging in Older Monkeys, New Research Shows

Engineered Immune Cells Can Hunt Down and Eliminate Aging Cells

U.S. Government Allocates $1.5 Billion Towards Promising New Age-Reversal Technology: Epigenetic Reprogramming

New Study Reveals Activating Sirtuins Could Reverse Heart Aging

Caloric Restriction Preserves Muscle Strength Despite Muscle Loss: National Institute on Aging