Scientists uncover blood metabolic byproducts as signs of aging that may provide targets for age-related disease prevention through supplementation.

red-blood-cells

Researchers find blood metabolite markers indicative of aging and age-related diseases which may translate to identifying therapeutic supplement targets.

Basic Research

Back to back research papers show CD38 enzymes on immune cells driving age-related decline of the critical molecule.

cd38

CD38

Two recent studies published in Nature Metabolism indicate CD38 enzymes on M1 macrophages consume NAD+ and NMN leading to progressive NAD+ level reductions with age.

CD38 Enzymes on Immune Cells Drive NAD+ Decline

Researchers review evidence supporting the importance of how nicotinamide adenine dinucleotide (NAD+) is distributed to different cell structures in health, disease, and aging.

creative-image-of-embryonic-stem-cells

Creative image of embryonic stem cells

Researchers review NAD+ distribution between cellular structures in health, disease, and aging. Future discoveries in NAD+ biology will come from scientists with distinct skill sets.

Subdivision of NAD+ is Critical to Mammalian Life | NMN

Scientists repurposed a blood cancer treatment using genetically modified immune cells called CAR T cells to reverse age-associated tissue damage.

blood-cancer

A cellular therapy typically used against blood cancer called CAR T therapy improved tissue health by destroying senescent cells in mice.

Fluctuating Molecule Levels in the Blood May Indicate Signs of Aging

CD38 Enzymes on Immune Cell Surfaces Drive Declining NAD+ Levels with Age

The Cell Compartment Subdivision of NAD+ is Critical to Mammalian Life

Blood Cancer Therapy May Provide a Strategy for Age-Related Disease Treatments