Scientists repurposed a blood cancer treatment using genetically modified immune cells called CAR T cells to reverse age-associated tissue damage.

blood-cancer

A cellular therapy typically used against blood cancer called CAR T therapy improved tissue health by destroying senescent cells in mice.

4-week-old, 8-week-old, and 36-month-old Sprague Dawley rats
Lycopene: 100 mg/kg IP injection

Tomato Compound Prevents Signs of Diabetes and Reverses Blood Vessel Aging

Wuhan University researchers show that  lycopene - an antioxidant found in plants - prevents insulin resistance and promotes blood vessel growth in aged rats. 


foodsrichinlycopenewithstructuralchemicalformulaoflycopene

Foods,Rich,In,Lycopene,With,Structural,Chemical,Formula,Of,Lycopene

Model: C57BL/6J mice
Dosage: 5 mg/kg dasatinib (D) + 50 mg/kg quercetin (Q)

Scientists find that old mice treated with the senolytics dasatinib plus quercetin (D+Q) heal from bone fractures like young mice.


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main image under 400 kB

Dr. Lianping Xing & Her Team | University of Rochester Medical Center

Model: C57BL/6 mice
Dose &amp; Administration: 14 mg/kg rapamycin, 1000 mg/kg acarbose and phenlbutryate mixed in chow

Study Identifies New Age-Reversing Drug Cocktail 

A cocktail of rapamycin, acarbose, and phenylbutyrate reduces fat, improves learning, and enhances strength and endurance in aged mice. 

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Picture1

Age Reversed Kidney Tissue | Jiang et al., 2022 | Scientific Reports 

Dose: 20 mg/kg, five days a week
Administration: intraperitoneal (abdominal cavity)injection

Turmeric Metabolite Improves Age-Related Memory Deficits

Mexican scientists show that curcumin — the primary metabolite found in turmeric — improves learning and memory while increasing neuroplasticity and reducing inflammation in the brain of aged mice. 


curcumin

Diabetics Taking Metformin Increases Birth Defect Risk

A collaboration between Stanford University School of Medicine and University of Southern Denmark shows that men taking metformin pre-conception increases risk of birth defects.


human-fetus

NAD+ Controls Muscle Repair Clock

Northwestern University scientists find that boosting NAD+ re-establishes the circadian rhythm driving muscle cell formation after muscle injury in mice 

skelatal-muscle-fibers

The loss of NAD+ during muscle repair is found to be the cause of circadian clock abnormalities, according to Harvard and UCSF researchers.

Skin &amp; Muscle

NAD+ Precursor Supplementation Decreases Obesity-induced Subfertility

Chinese researchers suggest that NAD+ precursor supplementation is a potential therapeutic approach for treating obesity-related ovarian infertility and metabolic disturbance in offspring.


sperm-cells-fertilize-egg

NAD+ precursor supplementation could be used to treat obesity-related ovarian infertility and metabolic disturbances in children.

Why does NAD+ Drop During Aging?

The chronic inflammation induced by senescent cells depletes NAD+, leading to the organ dysfunction characteristic of aging and age-related disease.  

wheelchair-guy

wheelchair guy

Canadian scientists find that destroying "zombie-like" senescent neural stem cells in the hippocampus with the senolytic ABT-263 restores neurogenesis and improves spatial memory in middle-aged mice. 


confocallaserscanningmicroscopeimageofcellsinthehippocampus

Confocal,Laser,Scanning,Microscope,Image,Of,Cells,In,The,Hippocampus

By deleting zombie cells from the brain's memory pathways, Canadian scientists improve learning and memory in mice.

Osaka University scientists find that the coronavirus induces the arrest of cell growth and replication (senescence), a phenomenon linked to aging and age-related disease, driving the persistent inflammation observed in post-acute COVID-19 syndrome. 

virus-lungs

Coronavirus causes aging-related zombie cells in COVID-19 patients' lungs, according to Japanese researchers.

Blood Cancer Therapy May Provide a Strategy for Age-Related Disease Treatments

Study Suggests Tomato Compound Prevents Signs of Diabetes and Reverses Blood Vessel Aging

Senolytics Restore Bone Healing Capacity in Older Age

University of Washington Study Identifies New Age-Reversing Drug Cocktail

Study Shows that Curcumin Improves Learning and Memory in Older Mice

Offspring of Diabetics Taking Metformin Have Higher Risk of Birth Defects

NAD+ Restores Essential Clock for Muscle Repair

Study Shows that NAD+ Precursor Supplementation Decreases Obesity-induced Subfertility in Mice

What Drives Aging?

Senolytic Improves Age-Related Memory Loss

Coronavirus Creates Zombie Cells that Fuel Post-Acute COVID-19 Syndrome