Scientists repurposed a blood cancer treatment using genetically modified immune cells called CAR T cells to reverse age-associated tissue damage.

blood-cancer

A cellular therapy typically used against blood cancer called CAR T therapy improved tissue health by destroying senescent cells in mice.

Model: C57BL/6 mice
Dose &#038; Administration: 14 mg/kg rapamycin, 1000 mg/kg acarbose and phenlbutryate mixed in chow

UW Study Shows New Drug Cocktail Reverses Signs of Aging 

A cocktail of rapamycin, acarbose, and phenylbutyrate reduces fat, improves learning, and enhances strength and endurance in aged mice. 

university-of-washington-school-of-medicine

University-of-Washington-School-of-Medicine

Dose: 20 mg/kg, five days a week
Administration: intraperitoneal (abdominal cavity)injection

Turmeric Metabolite Improves Age-Related Memory Deficits

Mexican scientists show that curcumin — the primary metabolite found in turmeric — improves learning and memory while increasing neuroplasticity and reducing inflammation in the brain of aged mice. 


curcumin

Diabetics Taking Metformin Increases Birth Defect Risk

A collaboration between Stanford University School of Medicine and University of Southern Denmark shows that men taking metformin pre-conception increases risk of birth defects.


human-fetus

NAD+ Controls Muscle Repair Clock

Northwestern University scientists find that boosting NAD+ re-establishes the circadian rhythm driving muscle cell formation after muscle injury in mice 

skelatal-muscle-fibers

The loss of NAD+ during muscle repair is found to be the cause of circadian clock abnormalities, according to Harvard and UCSF researchers.

Skin &amp; Muscle

NAD+ Precursor Supplementation Decreases Obesity-induced Subfertility

Chinese researchers suggest that NAD+ precursor supplementation is a potential therapeutic approach for treating obesity-related ovarian infertility and metabolic disturbance in offspring.


sperm-cells-fertilize-egg

NAD+ precursor supplementation could be used to treat obesity-related ovarian infertility and metabolic disturbances in children.

Why does NAD+ Drop During Aging?

These three interconnected cell processes perpetuate aging in a self-sustaining loop. 

wheelchair-guy

wheelchair guy

Canadian scientists find that destroying "zombie-like" senescent neural stem cells in the hippocampus with the senolytic ABT-263 restores neurogenesis and improves spatial memory in middle-aged mice. 


confocallaserscanningmicroscopeimageofcellsinthehippocampus

Confocal,Laser,Scanning,Microscope,Image,Of,Cells,In,The,Hippocampus

By deleting zombie cells from the brain's memory pathways, Canadian scientists improve learning and memory in mice.

Osaka University scientists find that the coronavirus induces the arrest of cell growth and replication (senescence), a phenomenon linked to aging and age-related disease, driving the persistent inflammation observed in post-acute COVID-19 syndrome. 

virus-lungs

Coronavirus causes aging-related zombie cells in COVID-19 patients' lungs, according to Japanese researchers.

Researchers utilize an NAD+ precursor to improve oocyte health in obese mice, boost NAD+ levels, and minimize oxidative stress. 

sperm-egg-cell

An NAD+ precursor is used by researchers to promote oocyte health, increase NAD+ levels, and reduce oxidative stress in obese mice.

Injury to lung cells that extract oxygen from air shuts down their proliferative abilities, which can be alleviated by nicotinamide mononucleotide (NMN).

satisfiedcalmbusinessmantakingbreaktorelaxfinishedworksitting

Satisfied,Calm,Businessman,Taking,Break,To,Relax,Finished,Work,Sitting

Nicotinamide mononucleotide (NMN), a nicotinamide adenine dinucleotide (NAD+) precursor, effectively alleviates lung cell senescence in mice.

Blood Cancer Therapy May Provide a Strategy for Age-Related Disease Treatments

University of Washington Study Shows Anti-Aging Cocktail Improves Weight, Cognition, and Strength in Middle-Aged Mice

Study Shows that Curcumin Improves Learning and Memory in Older Mice

Offspring of Diabetics Taking Metformin Have Higher Risk of Birth Defects

NAD+ Restores Essential Clock for Muscle Repair

Study Shows that NAD+ Precursor Supplementation Decreases Obesity-induced Subfertility in Mice

What Could Drive NAD+ Depletion During Aging?

Senolytic Improves Age-Related Memory Loss

Coronavirus Creates Zombie Cells that Fuel Post-Acute COVID-19 Syndrome

NAD+ Booster Improves Oocyte Quality

NMN Limits Senescence of Vital Lung Cells