Key Points
- RESTORIN combines patented brainchild anti-aging technologies from Harvard, Mayo, and Scripps.
- RESTORIN utilizes multiple proprietary forms of NAD-boosting and senolytic molecules, as well as an elaborate targeted-delivery system.
After years of development and multiple delays, Seragon finally launched its highly sought-after anti-aging and longevity nutraceutical RESTORIN, previously known as SRN-901N. The Irvine, California-based biopharma company has undergone intense negotiations with multiple leading research institutions to obtain necessary technologies and patent licensing to deliver RESTORIN to the market.
The technologies underlying RESTORIN work through multiple mechanisms that attack the aging process at the cellular level. Some of these technologies are designed to increase the abundance of an essential molecule called nicotinamide adenine dinucleotide (NAD+), while others are aimed at limiting the number of harmful senescent cells.
NAD+ is involved in numerous cellular reactions that produce energy, maintain DNA, and bolster overall cellular health. Pro-longevity proteins that protect cells against oxidative stress and DNA damage called sirtuins rely on sufficient NAD+ levels to function. Falling NAD+ levels with age have been linked with metabolic, cardiovascular, and neurological decline.
With its discovery in 1906, researchers have known about NAD+ for quite some time. However, it hasn’t been until recently that scientists have been able to figure out how to increase its levels with an oral delivery method. Since the body cannot readily absorb NAD+, researchers have turned to supplementing with its molecular building block precursors in the last decade. Studies have shown that NAD+’s precursors are key to increase cellular NAD+ level.
Another key component in RESTORIN is its senolytic complex. Senolytics are compounds that specifically target and remove age-associated senescent cells – dormant cells that release inflammatory molecules to surrounding cells, accelerating widespread organ aging and impeding tissue repair. Moreover, rodent studies have shown that senolytic agent supplementation increases aged mouse remaining lifespan by as much as 60%, illustrating its longevity-promoting potential.
“The Most Advanced Senolytic NAD+ Nutraceutical to Date”
With its proprietary NAD+ precursors and senolytic agents, as well as extensive patent licensing from leading research institutions including Harvard University, Mayo Clinic, and Scripps Research, the high-anticipated RESTORIN has been regarded as “the most advanced senolytic NAD+ nutraceutical to date.”
“There are many studies that point to these molecules having a positive impact on aging and aging-related health conditions, but, so far, no one has been able to combine them at an optimal ratio to achieve a synergistic effect,” said Seragon senior scientist David Brown, PhD, who helped develop RESTORIN. “We’ve been able to develop advanced forms of these molecules and a series of complex combinations to combat aging, using the best science we have. This is truly a game-changer.”
To solve the oral bio-availability challenge, Seragon’s team has coupled RESTORIN’s advanced proprietary combination with its SERC targeted-delivery technology, which utilizes water soluble (hydrophilic) and fat soluble (lipophilic) vehicles as well as a pH-responsive enteric delivery system that drives maximum absorption.
“In the field of aging, a critical issue to resolve is how to deliver NAD+ precursors in a way that best boosts cellular NAD+ to achieve healthier aging,” said Dr. Brown. “We believe that RESTORIN has achieved best-in-class performance in this regard, which is truly a breakthrough. Especially when you consider recent studies showing an increase in NAD+ can even make immunotherapies against cancer more effective, it’s very exciting to be a part of this development.”
“It’s very thrilling to see aging research advancing ways to help people age slower, better, and healthier,” he added.
The only potential setback for RESTORIN might be its prices and availability. Depending on the version, each bottle of RESTORIN costs from $200 to over $300, and it’s only available through its official website, www.restorin.com.
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