Participants: Middle-aged adults carrying two copies of the APOE4 gene 
Dosage: 1 mg/kg/day of rapamycin for 4 weeks

The prescription drug rapamycin a.k.a. sirolimus, an FDA-approved mTOR inhibitor, increases the brain volume of cognitively normal individuals at risk for developing Alzheimer’s disease. 


One of the study’s investigators, Talissa Altes, M.D. (Image: Missouri.edu).

Brain &amp; Neurons

New Study Shows How Boosting NAD+ Could Protect Against Parkinson’s

Recent research from Zhejiang University School of Medicine in Hangzhou, China, demonstrates that administering NAD+ precursors to mice can safeguard the brain against neurodegeneration

(Zhejiang University School of Medicine | Panda Admission)

2023 Top 10 New Drugs: Weight-loss Wonder Drug Tirzpatide, Strongest "Longevity Drug" Seragon RESTORIN Make the List 

Explore the top 10 new drugs of 2023, featuring breakthroughs like weight-loss wonder Tirzpatide and longevity drug Seragon RESTORIN. Dive into advancements targeting aging, rare diseases, and conditions like Alzheimer's Disease.

Explore the top 10 new drugs of 2023, featuring breakthroughs like weight-loss wonder Tirzpatide and longevity drug Seragon Restorin. Dive into advancements targeting aging, rare diseases, and conditions like Alzheimer's Disease.

Aging &amp; Longevity

Model: APP/PS1 Alzheimer&#8217;s Disease mice
Dosage: 10 mg/kg/day Au NPs

A new study showed that when mice with Alzheimer’s disease ate gold particles, they had less brain inflammation and cognitive decline.

Model: Senescence-accelerated mouse prone 8 (SAMP8) mice
Dosage: 5 mg/kg per day of oral trigonelline

New Study Reveals Coffee-Derived Molecule Trigonelline Defends Against Cognitive Decline

Japanese researchers have demonstrated that trigonelline can prevent learning and memory impairment, reduce neuroinflammation, and replenish neurotransmitter levels in a mouse model of accelerated aging.

(A ring of coffee beans surrounding a trigonelline molecule | NAD.com)

Learn how a new study uncovers the incredible power of a molecule found in coffee, called Trigonelline, in defending against forgetfulness and keeping your brain sharp. Get the scoop at NAD.com!

Search Result: Alzheimer's symptoms

Neurodegeneration Reversed with mTOR Inhibitor Drug in New Alzheimer’s Study

New Study Shows How Boosting NAD+ Could Protect Against Parkinson’s

2023 Top 10 New Drugs: Weight-loss Wonder Drug Tirzpatide, Strongest “Longevity Elixir” Seragon RESTORIN Make the List

Researchers Use Gold Nanoparticles to Treat Neurodegenerative Disease

New Study Reveals Coffee-Derived Molecule Trigonelline Defends Against Cognitive Decline