Model: Male C57BL/6 mice 
Dosage: 10 mg/kg of glyburide via intragastric injections or 500 mg/kg of NMN by oral water supply daily starting at 12 months of age until death

Common Diabetes Medication Extends Life, Suggests New Study

Researchers show that glyburide, an anti-diabetes drug, extends lifespan and reduces frailty in naturally aged mice.

(The chemical structure of glyburide, a diabetes medication | PubChem)

Aging &amp; Longevity

Ezra launches a $5,995 longevity scan with Bryan Johnson, using advanced imaging to detect early signs of aging, cancer, and key health risks.









Model: Male Monkeys 
Dosage: 20 mg/kg/day of metformin

Supplementation of metformin — a first-line treatment for type 2 diabetes and the second-most prescribed medication in the U.S. — improves the learning and memory of older monkeys. 

Brain &amp; Neurons

Learning from Incredibly Resilient Creatures to Develop Anti-Aging Drugs

Dr. Ashley Zehnder, CEO of FaunaBio, an aging research biotech company, learns from long-lived animals to develop drugs against age-related diseases.

(A 13-lined ground squirrel | Carnegie Museum of Natural History)

FaunaBio CEO and veterinarian scientist Dr. Ashley Zehnder shares how she utilizes gene activity profiles from long-lived hibernating mammals to develop drugs against human age-related diseases.

Industry

<ul>
<li style="font-weight: 400;" aria-level="1">The monkeys used in the study, including eight young ones (4–6 years old, four females and four males) and eight aged ones (18–21 years old, four females and four males), were originally from Southeast Asia.</li>
<li style="font-weight: 400;" aria-level="1">Three groups of male C57BL6/J mice: young-lenti-Luc (2-month-old), aged-lenti-Luc (24-month-old) and aged-lenti-SIRT2 (24-month-old).</li>
<li style="font-weight: 400;" aria-level="1">hiPSC derived CMs</li>
</ul>

New Study Reveals Activating Sirtuins Could Reverse Heart Aging 

Researchers have identified a sirtuin (SIRT2) as a therapeutic target for age-related cardiovascular disease.

Search Result: Cardiovascular Fibrosis

Common Diabetes Medication Extends Life, Suggests New Study

Would You Pay $6,000 to Know What Might Kill You?

Metformin Slows Brain Aging in Older Monkeys, New Research Shows

Learning from Incredibly Resilient Creatures to Develop Anti-Aging Drugs

New Study Reveals Activating Sirtuins Could Reverse Heart Aging