Model: Male Monkeys 
Dosage: 20 mg/kg/day of metformin

Supplementation of metformin — a first-line treatment for type 2 diabetes and the second-most prescribed medication in the U.S. — improves the learning and memory of older monkeys. 

Brain &amp; Neurons

Learning from Incredibly Resilient Creatures to Develop Anti-Aging Drugs

Dr. Ashley Zehnder, CEO of FaunaBio, an aging research biotech company, learns from long-lived animals to develop drugs against age-related diseases.

(A 13-lined ground squirrel | Carnegie Museum of Natural History)

FaunaBio CEO and veterinarian scientist Dr. Ashley Zehnder shares how she utilizes gene activity profiles from long-lived hibernating mammals to develop drugs against human age-related diseases.

Industry

<ul>
<li style="font-weight: 400;" aria-level="1">The monkeys used in the study, including eight young ones (4–6 years old, four females and four males) and eight aged ones (18–21 years old, four females and four males), were originally from Southeast Asia.</li>
<li style="font-weight: 400;" aria-level="1">Three groups of male C57BL6/J mice: young-lenti-Luc (2-month-old), aged-lenti-Luc (24-month-old) and aged-lenti-SIRT2 (24-month-old).</li>
<li style="font-weight: 400;" aria-level="1">hiPSC derived CMs</li>
</ul>

New Study Reveals Activating Sirtuins Could Reverse Heart Aging 

Researchers have identified a sirtuin (SIRT2) as a therapeutic target for age-related cardiovascular disease.

Cardiovascular

Combining Micronutrients with NAD+ Precursors to Maximize Their Effects

Mixing nutraceutical molecules with nicotinamide adenine dinucleotide (NAD+) precursors may synergistically boost and maintain NAD+ levels while bolstering their longevity-promoting benefits.

(An aged individual’s hand alongside a younger person’s hand, each holding different types of supplement capsules | NAD.com)

Combining nutraceuticals with NAD+ precursors may be a potent way to boost and maintain NAD+ levels while promoting other anti-aging benefits.

Reviews

Model: Female C57BL6 mice 
Dosage: Intraperitoneal (abdominal cavity) injection of 25 mg/kg of fisetin every other day for 6 days

Fisetin — a flavonoid found in tea, fruits, and vegetables — reduces kidney damage, inflammation, and oxidative stress in a mouse model for age-related kidney disease. 


Fisetin is a molecule found in plant-based foods and drinks like green tea and strawberries.

Search Result: Cardiovascular Fibrosis

Metformin Slows Brain Aging in Older Monkeys, New Research Shows

Learning from Incredibly Resilient Creatures to Develop Anti-Aging Drugs

New Study Reveals Activating Sirtuins Could Reverse Heart Aging

Enhancing Longevity-Promoting Cocktails: Combining Micronutrients with NAD+ Precursors to Maximize Their Effects

The Senolytic Fisetin Shields the Kidney from Injury and Damage: Korean Study