Model: Male C57BL/6 mice 
Dosage: 10 mg/kg of glyburide via intragastric injections or 500 mg/kg of NMN by oral water supply daily starting at 12 months of age until death

Common Diabetes Medication Extends Life, Suggests New Study

Researchers show that glyburide, an anti-diabetes drug, extends lifespan and reduces frailty in naturally aged mice.

(The chemical structure of glyburide, a diabetes medication | PubChem)

Aging &amp; Longevity

Model: 10-month-old and 22-month-old naturally aged mice / Rats with Partial Discectomy (PDE)-induced Temporomandibular Joint Osteoarthritis (TMJOA).
Dosage: 0.25% αKG and  0.75% αKG
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Longevity Compound Thwarts Age-Related Joint Degeneration

Researchers found that alpha-ketoglutarate (αKG) can treat osteoarthritis by preserving cartilage and reducing joint inflammation. 

Skin &amp; Muscle

Dr. Sinclair and collaborators show that an age-reversal technology that rejuvenates cells protects neurons from inflammation and cell death in mice. 

Brain &amp; Neurons

Participants: Middle-aged adults carrying two copies of the APOE4 gene 
Dosage: 1 mg/kg/day of rapamycin for 4 weeks

The prescription drug rapamycin a.k.a. sirolimus, an FDA-approved mTOR inhibitor, increases the brain volume of cognitively normal individuals at risk for developing Alzheimer’s disease. 


One of the study’s investigators, Talissa Altes, M.D. (Image: Missouri.edu).

Participants: Physically active and healthy older adults 
Dosage: 1 gram of omega-3s (330 mg EPA plus 660 mg DHA) per day, 2,000 IU of vitamin D per day, and 30 minutes of strength training exercises three times per week

While omega-3 supplementation slows biological aging, adding vitamin D and exercise further slows biological aging.

The “father of aging clocks” and senior study author Steve Horvath, PhD, of Harvard University (Image: quantamagazine.org). 

Search Result: Clinical Trials

Common Diabetes Medication Extends Life, Suggests New Study

Longevity Compound Thwarts Age-Related Joint Degeneration

Age-Reversal Tech Protects Against Neurodegeneration in Latest David Sinclair Study

Neurodegeneration Reversed with mTOR Inhibitor Drug in New Alzheimer’s Study

Harvard Study Reveals that Omega-3s, Vitamin D, and Exercise Additively Slow Biological Aging