Model: 16-month-old female C57BL/6 mice 
Dosage: 60 mg/kg/day of ABT-263 dissolved in drinking water for 7 days on, 7 days off, and 7 days on again

A senolytic compound and anti-cancer drug called ABT-263 accelerates ovarian aging in aged mice, suggesting it promotes infertility. 

Others

Model: 5xFAD mice
Dosage: 5-µL sprayed into each nostril at concentrations of 30 × 109/100 µL once weekly for two weeks

Exploring a Nasal Spray that Might Delay Alzheimer’s Progression by Years

Researchers use nano-sized vesicles derived from neural stem cells to preserve cognition as well as reduce brain inflammation and plaque buildup in an Alzheimer’s mouse model.

(An aged woman using an intranasal spray to avert Alzheimer's disease progression | NAD.com)

Brain &amp; Neurons

Model: 24-month-old female Sprague Dawley rats
Dosage: Undisclosed doses of pig-derived exosomes were injected into the rats every-other-day for eight days starting at day 1 and recommencing at days 68, 181, 280, and 377

Nano-Sized Vesicle Infusions Break Rat Lifespan Record

Nano-sized vesicles called exosomes derived from pig blood plasma significantly extended rat lifespan and broke the record for the longest-living rat.

(An image of Sima, the longest-recorded living rat, at 47 months of age | The Guardian)

Aging &amp; Longevity

Will Interventions that Delay Aging in Animals Work for Humans?

Researchers have shown that using certain agents targeting hallmarks of aging (like inflammation) can extend lifespan in mice, yet human trials are just beginning to uncover whether they work in humans.

(Aged individuals may benefit from aging interventions that work in animal models | NAD.com)

NAD+ is “The Future” of Longevity: What Celebrities are Doing to “Never Age”

Celebrities like Hailey Bieber, Jennifer Aniston, and Shannon Sharpe have endorsed NAD+ therapy, and studies suggest it could be an effective anti-aging intervention. 

Search Result: Clinical Trials

Which Anti-Aging Senolytic Supplement Should You Avoid?

Exploring a Nasal Spray that Might Delay Alzheimer’s Progression by Years

Nano-Sized Vesicle Infusions Break Rat Lifespan Record

Will Interventions that Delay Aging in Animals Work for Humans?

NAD+ is “The Future” of Longevity: What Celebrities are Doing to “Never Age”