Model: 16-month-old female C57BL/6 mice 
Dosage: 60 mg/kg/day of ABT-263 dissolved in drinking water for 7 days on, 7 days off, and 7 days on again

A senolytic compound and anti-cancer drug called ABT-263 accelerates ovarian aging in aged mice, suggesting it promotes infertility. 

Others

Will Interventions that Delay Aging in Animals Work for Humans?

Researchers have shown that using certain agents targeting hallmarks of aging (like inflammation) can extend lifespan in mice, yet human trials are just beginning to uncover whether they work in humans.

(Aged individuals may benefit from aging interventions that work in animal models | NAD.com)

Aging &amp; Longevity

Harvard anti-aging expert Dr. David Sinclair says that low-dose Viagra has become popular, but why?


Some studies suggest that Viagra may treat Alzheimer's disease. 

Brain &amp; Neurons

AI may be capable of discovering drugs that target the multitude of biological processes thought to underlie the aging process.  

AI may identify new targets for anti-aging drugs that humans may have overlooked. 

<ul>
<li style="font-weight: 400;" aria-level="1">Cultured human lung fibroblasts with five types of senescence: Etoposide,  P16INK4a over-expression, KRAS, replicative, and UV</li>
<li style="font-weight: 400;" aria-level="1">Irradiated or naturally aged (24 months old) mice were treated with mock- or mNKG2D-CAR T; irradiation-accelerated mouse model of aging, wild-type C57BL/6 mice (8 to 10 weeks old)</li>
<li style="font-weight: 400;" aria-level="1">Three rhesus macaques and two cynomolgus macaques</li>
</ul>

Engineered Immune Cells Can Hunt Down and Eliminate Aging Cells

A study demonstrates that engineered immune cells can serve as potent and selective medicine for cells at the center of aging and age-associated diseases. 


Search Result: Lung Cancer

Which Anti-Aging Senolytic Supplement Should You Avoid?

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Taking Viagra to Improve Memory and Prevent Dementia

How Scientists Plan to Cure Aging with AI

Engineered Immune Cells Can Hunt Down and Eliminate Aging Cells