Model: C57BL/6 mice and Zpmste24-deficient progeria mice
Dosage: .03% w/w of canagliflozin mixed into diets from day 3 to 20 weeks

Japanese Study: Common Diabetes Drug Clears Senescent Cells and Extends Lifespan

Japanese scientists uncover that a diabetes drug called canagliflozin removes senescent cells and moderately extends lifespan in a mouse model of premature aging.

(A laboratory mouse alongside the molecular structure of canagliflozin | NAD.com)

The diabetes medication canagliflozin clears senescent cells and extends lifespan in a mouse model of premature aging called progeria.

Aging &amp; Longevity

David Sinclair’s 2024 Anti-Aging Supplement Protocol

Longevity expert Dr. David Sinclair's 2024 anti-aging protocol includes NMN, fish oil, lipoic acid, resveratrol, metformin, spermidine, and more.

Model: UM-HET3 mice
Dosage: Astaxanthin was fed at 4,000 ppm in the diet beginning after weaning
Meclizine was fed at 800 ppm in the diet beginning after weaning
Administering fisetin started at 20 months old and was fed continuously or a repeated cycle of three days on and 11 days off at a target of 600 ppm in the diet

Over-the-Counter Wonders: New Research Highlights Two Compounds for a Longer Life

A consortium that examines longevity interventions in mice has found that the anti-nausea compound meclizine as well as the antioxidant astaxanthin extend male mouse lifespan.

(A long-lived mouse surrounded by potential lifespan-extending compounds | NAD.com)

A consortium of researchers has identified the anti-seasickness drug meclizine and the antioxidant astaxanthin as two compounds that significantly extend male mouse lifespan.

Model: Male Swiss albino mice
Dosage: 100 mg/kg per day for 18 months

New Study: Green Tea Molecule Extends Lifespan and Alleviates Fat Tissue Senescence

Epigallocatechin gallate (EGCG) supplementation substantially prolongs lifespan and suppresses senescence — an age-related, dysfunctional cellular state — in the fat tissue of mice.

(An aged mouse drinking green tea with an EGCG molecule on the left | NAD.com)

EGCG supplementation over 18 months increases median lifespan by ~25% and significantly lowers fat tissue senescence in mice.

Bryan Johnson: When Too Much Exercise Stops Slowing Aging 

When millionaire Bryan Johnson is asked why he doesn’t exercise more for longevity, he explains that there is such a thing as too much exercise. 


Bryan Johnson exercising (image: medium.com).

Search Result: Median Lifespan Extension

Japanese Study: Common Diabetes Drug Clears Senescent Cells and Extends Lifespan

David Sinclair’s 2024 Anti-Aging Supplement Protocol

Over-the-Counter Wonders: New Research Highlights Two Compounds for a Longer Life

New Study Reveals Green Tea Molecule Extends Lifespan and Alleviates Fat Tissue Senescence

Living Longevity Experiment Bryan Johnson: Is it Possible to Exercise Too Much?