Model: C57BL6/J
Dosage: 300 mg/kg/day of NMN in drinking water

NMN Protects Against Intestinal Damage Induced by Cancer Radiotherapy

The NAD+ precursor nicotinamide mononucleotide (NMN) reduces intestinal injury induced by radiation exposure and largely restores gut bacteria diversity in mice. 


(Cross-section of the intestine | Joan Carles Juarez, shutterstock)

Wild-type mtKeima transgenic mice/ Wild-type C57BL/6J mice
Nicotinamide Riboside: Oral supplementation via drinking water (24 mM) for 10 months

NIA Successfully Halts Age-Related Hearing Loss with NR

National Institute of Aging (NIA) scientists show that NR, a precursor to the life-preserving nicotinamide adenine dinucleotide (NAD+), exerts protective effects against age-related hearing loss in mice.  


NAD+ Boosting Agent Suppresses Brain Tumor Growth

Mitchell Cancer Institute (MCI) researchers find that elevated NAD+ levels help prevent the growth of chemotherapy-resistant brain tumor cells. 

Senior author, Dr. Robert W. Sobol | University of Southern Alabama Health 

Cancer

BALB/c (female, 8-12 weeks) mice
Free NAD+ (20 mg/kg)
NAD+-LP-CaP (20 mg/kg)

 NAD+ Nanoparticles Increase Survival from Sepsis by Over Fourfold 

University of Wisconsin researchers utilize nano-sized fat particles (lipid nanoparticles) loaded with NAD+ to increase survival, rescue immune cells, and preserve energy production. 


NAD+ loaded lipid nanoparticles significantly increase survival in septic mice, prevent immune cell death, and restore energy levels in critical organs, showing promise for sepsis treatment.

Immunity

A new study shows that fisetin, a senolytic compound, reduces depression-like behavior in mice with brain inflammation.

A senolytic medication that destroys growth-arrested brain cells is being used by Japanese researchers to treat depression in lupus patients.

Search Result: Tumor Suppression

Study Shows NMN Protects Against Intestinal Damage Induced by Cancer Radiotherapy

NIA Researchers Show NR Halts Age-Related Hearing Loss

MCI Scientists Find NAD⁺ Boosting Agent Suppresses Brain Tumor Growth

New Study Shows NAD⁺ Nanoparticles Increase Survival from Sepsis by Over Fourfold in Mice

Japanese Researchers Show Fisetin Alleviates Depression