Participants: healthy adults between the ages of 50 and 81
Dosage: 5 mg/week or 10 mg/week of rapamycin

One of the most potent anti-aging compounds rapamycin — an FDA-approved drug that inhibits mTOR — increases the lean body mass of older women while reducing their pain. 


Senior investigator Sajad Zalzala, MD (image: cnbc.com)

Clinical Trials

Model: 10-month-old and 22-month-old naturally aged mice / Rats with Partial Discectomy (PDE)-induced Temporomandibular Joint Osteoarthritis (TMJOA).
Dosage: 0.25% αKG and  0.75% αKG
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Longevity Compound Thwarts Age-Related Joint Degeneration: New Study Reveals

Researchers found that alpha-ketoglutarate (αKG) can treat osteoarthritis by preserving cartilage and reducing joint inflammation. 

Skin &amp; Muscle

A molecule found in the plasma of exercised mice reverses the brain aging of sedentary mice. 

(Image: UCSF.edu) Senior author Saul Villeda, PhD. 

Model: C57BL/6J mice
Dosage: 500 mg/kg/day of Urolithin A in food

Supplementing with urolithin A prevents age-related hearing loss and mitochondrial dysfunction in mice. 

Brain &amp; Neurons

Studies suggest that supplementation with melatonin may slow brain aging, thereby improving cognition. 

Search Result: anti-aging benefits

Anti-Aging Supplement Rapamycin Increases Muscle and Reduces Pain: New Results

Longevity Compound Thwarts Age-Related Joint Degeneration: New Study Reveals

Scientists Identify a Molecule that Mimics the Anti-Aging Effects of Exercise on the Brain

Urolithin A Anti-Aging Supplement Prevents Hearing Loss, New Research Shows

Does Melatonin Improve Cognition? What the Latest Research Says