Participants: Physically active and healthy older adults 
Dosage: 1 gram of omega-3s (330 mg EPA plus 660 mg DHA) per day, 2,000 IU of vitamin D per day, and 30 minutes of strength training exercises three times per week

While omega-3 supplementation slows biological aging, adding vitamin D and exercise further slows biological aging.

The “father of aging clocks” and senior study author Steve Horvath, PhD, of Harvard University (Image: quantamagazine.org). 

Aging &amp; Longevity

Aside from diet and exercise, senolytics — compounds that remove age-promoting cells — may rejuvenate the immune system and reduce the risk of neurodegeneration and dementia. 

Brain &amp; Neurons

Model: Male Sprague Dawley rats
Dosage: 1.5 mg/kg body or rapamycin injected 3 times a week for 4 weeks

The longevity-associated drug rapamycin diminishes muscle size and strength in young rats when compared to untreated but calorically restricted young rats. 

Skin &amp; Muscle

Model: Male Wistar rats (4-month-old young rats and 24-month-old old rats)
Dosage: Oral administration of the trypsin inhibitor tranexamic acid in drinking water for 14 days at a minimum dose of 0.39 g/kg/day after consuming about 40 mL/day of water

Newly Proposed Aging Mechanism: Digestive Enzymes May Be Eating Us from Within

University of California, San Diego researchers show digestive enzyme leakage from the intestines contributes to organ damage in old rats, offering what may be a new way to explain aging.

(Principal investigator, Geert Schmid-Schönbein | voiceofsandiego.org)

What if You Could Optimize Aging? Andrew Huberman Says These Methods Might Just Do That

Dr. Andrew Huberman highlights the potential of NAD+ and BPC-157 for aging while stressing the importance of practicing healthy daily habits. 

Search Result: caloric restriction

Harvard Study Reveals that Omega-3s, Vitamin D, and Exercise Additively Slow Biological Aging

Scientists Reveal How to Slow Brain Aging with Senolytics

If Too Young, Rapamycin Isn’t the Anti-Aging Remedy for You, Says New Research

Newly Proposed Aging Mechanism: Digestive Enzymes May Be Eating Us from Within

What if You Could Optimize Aging? Andrew Huberman Says These Methods Might Just Do That