The longevity gene klotho prolongs the lifespan of mice while preventing muscle, bone, and brain aging. 

Miguel Chillón, PhD, and Laura Rodriguez-Estevez, researchers from Universitat Autònoma de Barcelona in Spain, who conducted the study (image: uab.cat) 

Aging &amp; Longevity

Model: Male C57BL/6 mice 
Dosage: 10 mg/kg of glyburide via intragastric injections or 500 mg/kg of NMN by oral water supply daily starting at 12 months of age until death

Common Diabetes Medication Extends Life, Suggests New Study

Researchers show that glyburide, an anti-diabetes drug, extends lifespan and reduces frailty in naturally aged mice.

(The chemical structure of glyburide, a diabetes medication | PubChem)

Older adults with LDL cholesterol levels above 130 mg/dL live longer than older adults with LDL cholesterol levels below 130 mg/dL. 

The participants of the study were from Sardinia, Italy (image: businessinsider.com). 

Metabolism

Multi-Nation Expert Panel Agrees On Biomarkers of Aging

For the first time, a multi-nation panel of aging experts reached a consensus to designate markers of aging, which could make aging intervention testing easier.

(An aged individual holding pills and supplements meant to work against aging | UCLA)

Model: 10-month-old and 22-month-old naturally aged mice / Rats with Partial Discectomy (PDE)-induced Temporomandibular Joint Osteoarthritis (TMJOA).
Dosage: 0.25% αKG and  0.75% αKG
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Longevity Compound Thwarts Age-Related Joint Degeneration

Researchers found that alpha-ketoglutarate (αKG) can treat osteoarthritis by preserving cartilage and reducing joint inflammation. 

Search Result: health

One-Time Anti-Aging Gene Therapy Treatment Prolongs Life by 20%, New Study Shows

Common Diabetes Medication Extends Life, Suggests New Study

New Study Shows People with Higher Cholesterol Live Longer than People with Lower Cholesterol

Expert Panel Agrees On Biomarkers of Aging for Testing Therapeutics

Longevity Compound Thwarts Age-Related Joint Degeneration