Model: Male Wistar rats (4-month-old young rats and 24-month-old old rats)
Dosage: Oral administration of the trypsin inhibitor tranexamic acid in drinking water for 14 days at a minimum dose of 0.39 g/kg/day after consuming about 40 mL/day of water

Newly Proposed Aging Mechanism: Digestive Enzymes May Be Eating Us from Within

University of California, San Diego researchers show digestive enzyme leakage from the intestines contributes to organ damage in old rats, offering what may be a new way to explain aging.

(Principal investigator, Geert Schmid-Schönbein | voiceofsandiego.org)

Aging &amp; Longevity

Model: 16-month-old female C57BL/6 mice 
Dosage: 60 mg/kg/day of ABT-263 dissolved in drinking water for 7 days on, 7 days off, and 7 days on again

A senolytic compound and anti-cancer drug called ABT-263 accelerates ovarian aging in aged mice, suggesting it promotes infertility. 

Others

Brad Stanfield, MD, explains the pros and cons of supplementing with omega-3s, psyllium husk, and creatine. 

Scientists find that limiting folate (vitamin B9) beginning at mid-age leads to slowed aging in mice. 

Is reducing vitamin B9 intake good or bad in older age?

Assuming the science works, the cost of cryogenics and the typical lifecycles of companies make the prospect of suspended animation as a business a bit tricky.


Search Result: kidney damage

Newly Proposed Aging Mechanism: Digestive Enzymes May Be Eating Us from Within

Which Anti-Aging Senolytic Supplement Should You Avoid?

Dr. Brad Stanfield Reveals: 3 Anti-Aging Supplements with Proven Benefits

How Not Eating Leafy Greens Can Make You Age Slower

Humans Are Freezing Themselves in Hopes of Being Revived in the Future, but Is It Worth It?