Model: Male C57BL/6 mice 
Dosage: 10 mg/kg of glyburide via intragastric injections or 500 mg/kg of NMN by oral water supply daily starting at 12 months of age until death

Common Diabetes Medication Extends Life, Suggests New Study

Researchers show that glyburide, an anti-diabetes drug, extends lifespan and reduces frailty in naturally aged mice.

(The chemical structure of glyburide, a diabetes medication | PubChem)

Aging &amp; Longevity

Nutrition For Longevity: Optimizing Lifespan Through Dietary Choices

Nourishing the body with healthy dietary choices, including caloric restriction, time-restricted feeding, and plant-based diets enhances overall well-being and promotes longevity. 

Scientists Identify Hallmarks of Aging that Can Be Reversed 

Twelve underlying drivers of aging can potentially be slowed, prevented, or reversed to improve health and extend lifespan. 

Investigators Dr. Guido Kroemer (left) and Dr. Carlos Lopez-Otin (right) | El Comercio 

Reviews

Model: C57BL/6J
Dosage: Intraperitoneal (IP) injection of Met (50 mg/kg body weight/day, 
100 μl of 10 mg/ml metformin/mouse/day) for 8 weeks

Study Shows Metformin Prevents Connective Tissue Aging 

Metformin, a common diabetes medication, prevents the degradation of tendons – connective tissue between muscles and bones – by blocking cell aging and inflammation. 

Female KunMing Mice (2 months old, weight 20~25 g)
Metformin: 100 or 300 mg/kg/day for 6 weeks

Metformin Reverses Age-Related Immune System Decline 

Researchers from Zhengzhou University utilize metformin to attenuate the degeneration of the thymus - an immune organ that plays a vital role in the development and function of immune fighting cells (T cells). 


Metformin, a diabetes drug, shows promise in preserving thymus function and structure in aging mice by enhancing mitochondrial function and reducing senescent cells.

Search Result: thymus

Common Diabetes Medication Extends Life, Suggests New Study

Nutrition For Longevity: Optimizing Lifespan Through Dietary Choices

The Hallmarks of Aging and How To Target Them

Study Shows Metformin Prevents Connective Tissue Aging

New Study Shows Metformin Reverses Age-Related Thymus Degeneration by Boosting Mitochondrial Function