Model: 3-month-old LDLR−/− pigs
Dosage: 400 nM of SWNT or SWNT-SHP1i 
was infused intravenously for ~15–30 min, once a week, for 12 weeks

“Trojan Horse” Nanoparticles: A Breakthrough in Treatment for Atherosclerosis 

Stanford School of Medicine researchers develop safe nanoparticles that target dying cells in atherosclerotic plaque and reduce vascular inflammation.

Cardiovascular

Model: Humans between the ages of 21 and 72
Dosage: Oral dosage of 500 mg of nicotinamide, 600 mg of alpha lipoic acid, 10 mg of zinc, 20 mg of vitamin C, and 2,110 mg of a botanical blend containing green tea extract, rutin, parsley leaf extract, and black pepper fruit daily for 28 days

A New, Multifaceted Approach to Increasing Cellular NAD+ Levels

British researchers designed a nutraceutical to maximize nicotinamide adenine dinucleotide (NAD+) levels that significantly lowers biological age.

British researchers used a nutraceutical targeting multiple NAD+ biosynthesis- and breakdown-related enzymes to increase NAD+, lower inflammation, and increase sirtuins.

2023 Top 10 New Drugs: Weight-loss Wonder Drug Tirzpatide, Strongest "Longevity Drug" Seragon RESTORIN Make the List 

Explore the top 10 new drugs of 2023, featuring breakthroughs like weight-loss wonder Tirzpatide and longevity drug Seragon RESTORIN. Dive into advancements targeting aging, rare diseases, and conditions like Alzheimer's Disease.

Explore the top 10 new drugs of 2023, featuring breakthroughs like weight-loss wonder Tirzpatide and longevity drug Seragon Restorin. Dive into advancements targeting aging, rare diseases, and conditions like Alzheimer's Disease.

Aging &amp; Longevity

Model: APP-KI mouse model for Alzheimer’s disease
Intervention: Restricting feeding times within a 6-hour window each day for 3 months.

Intermittent Fasting Blocks Alzheimer’s Disease 

By restricting the feeding of Alzheimer’s model mice to 6 hours a day (18 hours of fasting), scientists prevent memory loss and counter brain pathology. 


Principal Investigator Dr. Paula Desplats | Desplats Lab 

Discover the groundbreaking research from UC San Diego demonstrating how intermittent fasting improves memory and alleviates brain pathology in Alzheimer's disease. Explore the implications of this study at NAD.

Intermittent Fasting Enhances Memory and Rescues Brain Pathology in Alzheimer's: UC San Diego Study | NAD

Brain &amp; Neurons

Model: C57BL/6N or BALB/c mice 
Dosage: 2 mg/kg of spermidine by intraperitoneal injection

Kyoto University researchers find spermidine inhibits tumor growth in mice by improving the mitochondrial function of anticancer immune cells.

(The study’s principal investigator, Dr. Tasuku Honjo | Japan Times)

Search Result: Antibodies

“Trojan Horse” Nanoparticles: A Breakthrough in Treatment for Atherosclerosis

A New, Multifaceted Approach to Increasing Cellular NAD+ Levels

2023 Top 10 New Drugs: Weight-loss Wonder Drug Tirzpatide, Strongest “Longevity Elixir” Seragon RESTORIN Make the List

Intermittent Fasting Improves Memory and Rescues Brain Pathology in Alzheimer’s: UC San Diego Study

Japanese Study Suggests Spermidine Enhances Immunity Against Cancer