Model: Male C57BL/6 mice 
Dosage: 10 mg/kg of glyburide via intragastric injections or 500 mg/kg of NMN by oral water supply daily starting at 12 months of age until death

Common Diabetes Medication Extends Life, Suggests New Study

Researchers show that glyburide, an anti-diabetes drug, extends lifespan and reduces frailty in naturally aged mice.

(The chemical structure of glyburide, a diabetes medication | PubChem)

Aging &amp; Longevity

Model: C57BL/6N mice 
Dosage: 1 g/kg carvedilol in food for one week followed by four weeks of PAGln treatment, consisting of 50 mg/kg per day by injection, and the same PAGln treatment for four weeks followed by 50 mg/kg per day of ABT263 via oral gavage for five days

New Study Suggests Combining Senolytics with Blood Pressure Medication Counteracts an Aging Gut

Carvedilol, a blood pressure medication, and the senolytic agent ABT-263 both attenuate cellular senescence—an age-related, dysfunctional cellular state—driven by a gut bacterial metabolite in mice.

Ezra launches a $5,995 longevity scan with Bryan Johnson, using advanced imaging to detect early signs of aging, cancer, and key health risks.









Will Interventions that Delay Aging in Animals Work for Humans?

Researchers have shown that using certain agents targeting hallmarks of aging (like inflammation) can extend lifespan in mice, yet human trials are just beginning to uncover whether they work in humans.

(Aged individuals may benefit from aging interventions that work in animal models | NAD.com)

Model: Male Monkeys 
Dosage: 20 mg/kg/day of metformin

Supplementation of metformin — a first-line treatment for type 2 diabetes and the second-most prescribed medication in the U.S. — improves the learning and memory of older monkeys. 

Search Result: Fibrosis

Common Diabetes Medication Extends Life, Suggests New Study

Combining Senolytics with Blood Pressure Medication Counteracts Gut Aging and Promotes Longevity, Suggests New Study

Would You Pay $6,000 to Know What Might Kill You?

Will Interventions that Delay Aging in Animals Work for Humans?

Metformin Slows Brain Aging in Older Monkeys, New Research Shows