Will Interventions that Delay Aging in Animals Work for Humans?

Researchers have shown that using certain agents targeting hallmarks of aging (like inflammation) can extend lifespan in mice, yet human trials are just beginning to uncover whether they work in humans.

(Aged individuals may benefit from aging interventions that work in animal models | NAD.com)

Aging &amp; Longevity

<p>Model: Male Monkeys </p>
<p>Dosage: 20 mg/kg/day of metformin </p>


Supplementation of metformin — a first-line treatment for type 2 diabetes and the second-most prescribed medication in the U.S. — improves the learning and memory of older monkeys. 

Brain &amp; Neurons

A potentially transformative antibody that inhibits the IL-11 protein increases mouse lifespan by 22% by targeting the same pathways as metformin and rapamycin. 

Antibody prolongs the lifespan of mice by 22%. 

AI may be capable of discovering drugs that target the multitude of biological processes thought to underlie the aging process.  

AI may identify new targets for anti-aging drugs that humans may have overlooked. 

Others

Learning from Incredibly Resilient Creatures to Develop Anti-Aging Drugs

Dr. Ashley Zehnder, CEO of FaunaBio, an aging research biotech company, learns from long-lived animals to develop drugs against age-related diseases.

(A 13-lined ground squirrel | Carnegie Museum of Natural History)

FaunaBio CEO and veterinarian scientist Dr. Ashley Zehnder shares how she utilizes gene activity profiles from long-lived hibernating mammals to develop drugs against human age-related diseases.

Search Result: Fibrosis

Will Interventions that Delay Aging in Animals Work for Humans?

Metformin Slows Brain Aging in Older Monkeys, New Research Shows

Anti-Aging Antibody Significantly Extends Life by 22% in Breakthrough Study

How Scientists Plan to Cure Aging with AI

Learning from Incredibly Resilient Creatures to Develop Anti-Aging Drugs