Model: 3-month-old LDLR−/− pigs
Dosage: 400 nM of SWNT or SWNT-SHP1i 
was infused intravenously for ~15–30 min, once a week, for 12 weeks

“Trojan Horse” Nanoparticles: A Breakthrough in Treatment for Atherosclerosis 

Stanford School of Medicine researchers develop safe nanoparticles that target dying cells in atherosclerotic plaque and reduce vascular inflammation.

Cardiovascular

Abdominal fat is associated with a dramatic increase in the risk of early death in generally healthy older adults who are not obese. 

(Image: AARP / AHMET YARALI / GETTY IMAGES)

Metabolism

Model: C57BL/6J mice and Abca1/g1-m/-m mice of both sexes and bone marrow-derived macrophages from C57BL/6J and Abca1/g1-m/-m mice
Dosage: 300 mg/kg of NMN by daily intraperitoneal injection for two weeks, 5 mg/kg of dasatinib and 50 mg/kg of quercetin by oral gavage for five consecutive days every two weeks for three months, and a 500 μM concentration of NMN for bone marrow-derived macrophages in laboratory dishes

Revitalizing Immune Cells & Eye Function: NMN Study Unveils Remarkable Findings

A new study suggests that NMN reverses an age-associated dysfunctional cellular state — senescence — in immune cells and restores eye function in an age-related eye disease mouse model.

(An anatomical view of an eye with age-related macular degeneration | NAD.com)

NMN reverses an age-related dysfunctional state in immune cells — senescence — and improves eye function in an age-related eye disease mouse model.

Model: Mice with obstructed nephropathy
Dosage: NAD+ (i.p.) 100 μg/mouse/day

NAD+ Decline Identified as a Therapeutic Target for Kidney Injury

Beijing researchers show that pediatric patients with a leading cause of kidney injury have dysregulated levels of NAD+ and that mice with obstructed kidneys treated with NAD+ have reduced kidney damage.


 NAD+ boosting emerges as a potential therapy for pediatric kidney injury, with studies showing reduced damage by inhibiting CD38 or supplementing NAD+.

Swedish scientists find that electrical stimulation of the vagus nerve resolves (stops/ends) inflammation by increasing specialized fatty acids derived from omega-3s in mice.  


Search Result: Macrophages

“Trojan Horse” Nanoparticles: A Breakthrough in Treatment for Atherosclerosis

New Research Study Claims Belly Fat Increases Risk of Early Death by Whopping 365%

Revitalizing Immune Cells & Eye Function: NMN Study Unveils Remarkable Findings

NAD+ Decline Identified as a Therapeutic Target for Kidney Injury

Study from Sweden Suggests Nerve Stimulation Device Could Slow Aging