A molecule known as miR-302b prolongs the life of mice by “waking up” senescent cells — “sleeping” cells that contribute to life-shortening chronic diseases. 

Depiction of microRNA molecules (Image: Artur Plawgo/iStock Photo/MIT.edu). 

Aging &amp; Longevity

Model: C57BL/6N mice 
Dosage: 1 g/kg carvedilol in food for one week followed by four weeks of PAGln treatment, consisting of 50 mg/kg per day by injection, and the same PAGln treatment for four weeks followed by 50 mg/kg per day of ABT263 via oral gavage for five days

New Study Suggests Combining Senolytics with Blood Pressure Medication Counteracts an Aging Gut

Carvedilol, a blood pressure medication, and the senolytic agent ABT-263 both attenuate cellular senescence—an age-related, dysfunctional cellular state—driven by a gut bacterial metabolite in mice.

The Dementia Surge: New Study Projects Cases to Double by 2060

Researchers project dementia cases in the U.S. to double by 2060, revealing higher incidence in women, Black adults, and APOE ε4 carriers

Brain &amp; Neurons

Globally, 9.8% of Diabetes Cases Attributable to Sugary Drinks

A worldwide assessment suggests that 9.8% of new diabetes cases and 3.1% of new cardiovascular disease cases are attributable to sugar-sweetened beverage consumption.

(The study’s principal investigator, Dr. Dariush Mozafarrian | ResearchGate)

Metabolism

Model: 3-month-old LDLR−/− pigs
Dosage: 400 nM of SWNT or SWNT-SHP1i 
was infused intravenously for ~15–30 min, once a week, for 12 weeks

“Trojan Horse” Nanoparticles: A Breakthrough in Treatment for Atherosclerosis 

Stanford School of Medicine researchers develop safe nanoparticles that target dying cells in atherosclerotic plaque and reduce vascular inflammation.

Search Result: Nature Medicine

New Age-Reversal Therapy Prolongs Life by Targeting Senescent Cells

Combining Senolytics with Blood Pressure Medication Counteracts Gut Aging and Promotes Longevity, Suggests New Study

The Dementia Surge: New Study Projects Cases to Double by 2060

Globally, 9.8% of Diabetes Cases Attributable to Sugary Drinks

“Trojan Horse” Nanoparticles: A Breakthrough in Treatment for Atherosclerosis